CLDN19 and SLAMF6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN19	SLAMF6
Description		claudin 19	SLAM family member 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Paranodal Junction Schmidt-Lanterman Incisure Apical Junction Complex Perinuclear Region Of Cytoplasm Tight Junction Anchoring Junction Mesaxon	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity Paracellular Tight Junction Channel Activity	Protein Binding
	Biological Process	Retinal Pigment Epithelium Development Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cell Junction Assembly Apical Junction Assembly Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Regulation Of Transepithelial Transport Paracellular Transport	Adaptive Immune Response Immune System Process Immune Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production T Cell Activation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity T-helper 17 Cell Lineage Commitment
Pathways		Tight junction interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Graves' disease ( 23612905) Multiple sclerosis ( 24076602) Rheumatoid arthritis ( 32723749)
Interacting Genes		63 interacting genes: AQP6 AQP9 BCL2L13 BIK BSCL2 BTN2A1 CD200R1 CD53 CD74 CLEC14A CLEC2D CLRN1 CREB3 CXCR3 CYSRT1 ERGIC3 FAM209A FCGR1A FCGRT FKBP7 FNDC9 GGT7 GJA8 GORAB GPR161 GPX8 HSD17B13 ICAM3 IFNGR2 IL3RA KEL KIR2DL3 KRT31 KRT34 LAPTM5 LRRC25 LRRC4C MFF MS4A14 MS4A4A MUC1 PDZK1IP1 PKD2L1 PLEKHB2 PVR SAR1A SCARB2 SGPL1 SLAMF6 SLC10A1 SLC35H1 SPACA1 SRPK2 STOM STOML3 SUSD3 SYNE4 TM4SF18 TMEM106C TMEM248 TMEM52B TMEM80 TNFSF14	11 interacting genes: BRICD5 CLDN19 CXCL14 JAGN1 PTPN11 PTPN6 RABAC1 SH2D1A TMBIM6 TMPPE ZAP70
Entrez ID		149461	114836
HPRD ID		10834	05920
Ensembl ID		ENSG00000164007	ENSG00000162739
Uniprot IDs		Q8N6F1	B4E1U5 Q96DU3
PDB IDs			2IF7
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding External Side Of Plasma Membrane Plasma Membrane	Phosphotyrosine Residue Binding Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Leukocyte Mediated Immunity Immune Effector Process Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Killing Regulation Of T Cell Proliferation Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Negative Regulation Of Immune System Process Immune System Process Regulation Of T Cell Receptor Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Myeloid Cell Differentiation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Positive Regulation Of T Cell Activation Cell Activation Epididymis Development Regulation Of Leukocyte Proliferation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Myeloid Cell Development Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Negative Regulation Of T Cell Proliferation Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Intestinal Epithelial Cell Migration Endoribonuclease Inhibitor Activity T Cell Aggregation Mesaxon Protein Dephosphorylation Negative Regulation Of Cell Communication
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