CLDN19 and PLEKHB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN19	PLEKHB2
Description		claudin 19	pleckstrin homology domain containing B2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Paranodal Junction Schmidt-Lanterman Incisure Apical Junction Complex Perinuclear Region Of Cytoplasm Tight Junction Anchoring Junction Mesaxon	Endosome Membrane Recycling Endosome Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity Paracellular Tight Junction Channel Activity	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding
	Biological Process	Retinal Pigment Epithelium Development Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cell Junction Assembly Apical Junction Assembly Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Regulation Of Transepithelial Transport Paracellular Transport	Regulation Of Cell Differentiation
Pathways		Tight junction interactions
Drugs
Diseases
GWAS
Interacting Genes		63 interacting genes: AQP6 AQP9 BCL2L13 BIK BSCL2 BTN2A1 CD200R1 CD53 CD74 CLEC14A CLEC2D CLRN1 CREB3 CXCR3 CYSRT1 ERGIC3 FAM209A FCGR1A FCGRT FKBP7 FNDC9 GGT7 GJA8 GORAB GPR161 GPX8 HSD17B13 ICAM3 IFNGR2 IL3RA KEL KIR2DL3 KRT31 KRT34 LAPTM5 LRRC25 LRRC4C MFF MS4A14 MS4A4A MUC1 PDZK1IP1 PKD2L1 PLEKHB2 PVR SAR1A SCARB2 SGPL1 SLAMF6 SLC10A1 SLC35H1 SPACA1 SRPK2 STOM STOML3 SUSD3 SYNE4 TM4SF18 TMEM106C TMEM248 TMEM52B TMEM80 TNFSF14	51 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CFTR CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A RUNX1 SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A
Entrez ID		149461	55041
HPRD ID		10834	15144
Ensembl ID		ENSG00000164007	ENSG00000115762
Uniprot IDs		Q8N6F1	A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7
PDB IDs			3AJ4 3VIA
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding External Side Of Plasma Membrane Plasma Membrane	Protein Tag Activity Endosome Membrane ESCRT-0 Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Macromolecule Catabolic Process Endocytic Vesicle Membrane Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Autophagy Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin Binding Clathrin Vesicle Coat ERAD Pathway Early Endosome Membrane Bleb Assembly Multivesicular Body Sorting Pathway Endosome Protein K11-linked Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
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