CLDN19 and PKD2L1

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		CLDN19	PKD2L1
Description		claudin 19	polycystin 2 like 1, transient receptor potential cation channel
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Paranodal Junction Schmidt-Lanterman Incisure Apical Junction Complex Perinuclear Region Of Cytoplasm Tight Junction Anchoring Junction Mesaxon	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cilium Cell Surface Actin Cytoskeleton Membrane Cytoplasmic Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Receptor Complex Ciliary Membrane Non-motile Cilium
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity Paracellular Tight Junction Channel Activity	Calcium-activated Cation Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Monoatomic Cation Transmembrane Transporter Activity Calcium-activated Potassium Channel Activity Sour Taste Receptor Activity Identical Protein Binding Actinin Binding Transmembrane Transporter Binding Metal Ion Binding Metal Ion Transmembrane Transporter Activity Muscle Alpha-actinin Binding Alpha-actinin Binding PH-gated Monoatomic Ion Channel Activity Osmolarity-sensing Monoatomic Cation Channel Activity
	Biological Process	Retinal Pigment Epithelium Development Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cell Junction Assembly Apical Junction Assembly Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Regulation Of Transepithelial Transport Paracellular Transport	Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Smoothened Signaling Pathway Response To Water Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Protein Tetramerization Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To PH Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		Tight junction interactions
Drugs
Diseases
GWAS			A body shape index ( 34021172) Coronary artery disease ( 33020668 29212778) Diastolic blood pressure ( 30224653) Fatty acid desaturase activity (adipose tissue) ( 30453627) Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Macular thickness ( 30535121) Mean platelet volume ( 27863252 32888494) Obesity-related traits ( 23251661) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293) Phospholipid levels (plasma) ( 22359512) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 24625756 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Squamous cell lung carcinoma ( 28604730) Vaccenic acid (18:1n-7) levels ( 28298293)
Interacting Genes		63 interacting genes: AQP6 AQP9 BCL2L13 BIK BSCL2 BTN2A1 CD200R1 CD53 CD74 CLEC14A CLEC2D CLRN1 CREB3 CXCR3 CYSRT1 ERGIC3 FAM209A FCGR1A FCGRT FKBP7 FNDC9 GGT7 GJA8 GORAB GPR161 GPX8 HSD17B13 ICAM3 IFNGR2 IL3RA KEL KIR2DL3 KRT31 KRT34 LAPTM5 LRRC25 LRRC4C MFF MS4A14 MS4A4A MUC1 PDZK1IP1 PKD2L1 PLEKHB2 PVR SAR1A SCARB2 SGPL1 SLAMF6 SLC10A1 SLC35H1 SPACA1 SRPK2 STOM STOML3 SUSD3 SYNE4 TM4SF18 TMEM106C TMEM248 TMEM52B TMEM80 TNFSF14	4 interacting genes: CLDN19 TNNI1 TNNI2 TNNI3
Entrez ID		149461	9033
HPRD ID		10834	16063
Ensembl ID		ENSG00000164007	ENSG00000107593
Uniprot IDs		Q8N6F1	Q1L4F0 Q9P0L9
PDB IDs			3TE3 4GIF 6DU8
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding External Side Of Plasma Membrane Plasma Membrane	Troponin Complex Skeletal Muscle Contraction Cardiac Muscle Contraction Troponin T Binding Striated Muscle Contraction Muscle Contraction Muscle System Process Actin Binding Ventricular Cardiac Muscle Tissue Morphogenesis System Process Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Regulation Of Striated Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Mesaxon Regulation Of Muscle Contraction Cardiac Troponin Complex Troponin C Binding Regulation Of Transepithelial Transport Regulation Of Muscle System Process Transition Between Fast And Slow Fiber Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Myofibril Apical Junction Assembly Paracellular Tight Junction Channel Activity Retinal Pigment Epithelium Development Paracellular Transport Paranodal Junction Regulation Of Skeletal Muscle Adaptation Schmidt-Lanterman Incisure Action Potential Propagation Neuronal Action Potential Propagation Negative Regulation Of ATP-dependent Activity Tissue Morphogenesis Actin Filament-based Process Contractile Muscle Fiber Calcium Channel Inhibitor Activity Muscle Filament Sliding Actin-myosin Filament Sliding Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Heart Contraction Regulation Of System Process Apical Junction Complex Heart Process Regulation Of ATP-dependent Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell-cell Adhesion Mediator Activity Tight Junction Actin-mediated Cell Contraction Renal Absorption
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