GOLGA2 and APC

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		GOLGA2	APC
Gene Name		golgin A2	adenomatous polyposis coli
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Golgi Apparatus Cis-Golgi Network ER To Golgi Transport Vesicle Golgi Cisterna Membrane	Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoplasmic Microtubule Plasma Membrane Cell-cell Adherens Junction Tight Junction Lateral Plasma Membrane Lamellipodium Beta-catenin Destruction Complex Ruffle Membrane Microtubule Plus-end Axonal Growth Cone
	Molecular Function	Protein Binding Protein Kinase Binding Syntaxin Binding	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding
	Biological Process	Mitotic Cell Cycle Negative Regulation Of Protein Binding	Mitotic Cytokinesis Kidney Development Hair Follicle Development Protein Complex Assembly Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Cell Cycle Arrest Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Cell Adhesion Axonogenesis Negative Regulation Of Cell Proliferation Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process T Cell Differentiation In Thymus Somatic Stem Cell Maintenance Negative Regulation Of Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Adhesion Muscle Cell Cellular Homeostasis Thymus Development Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Positive Regulation Of Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Retina Development In Camera-type Eye Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Tight Junction Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Cell Cycle, Mitotic M Phase	misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Programmed Cell Death Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex Apoptotic cleavage of cellular proteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Apoptotic execution phase phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		281 interactors: ABLIM1 ADAP1 AES AFF4 ALKBH3 ALS2CR11 AMOTL2 ANKRD11 ANKRD36BP1 APC ARID5A ARL16 ARL4A ARNT2 ARPC3 ATP6V1C2 ATP6V1D ATP6V1G1 ATXN7 BAHD1 BARD1 BCAS2 BCL6B BMS1P5 BYSL C12orf50 C14orf105 C1orf109 C1orf35 C20orf195 CBX8 CCAR1 CCDC146 CCDC150 CCDC17 CCDC53 CCDC67 CCDC70 CCDC87 CCDC94 CCHCR1 CCNC CCNH CDC20B CDC5L CDC73 CDK1 CDK18 CDKL3 CENPP CEP57L1 CHCHD2 CHCHD3 CINP CORO1A CRMP1 CSPP1 CUL5 CYB5R2 DAXX DCTN4 DCX DDX6 DGCR6 DLGAP5 DLX6-AS1 DMTN DTX2 EIF3G EP300 EXOSC5 FAM110A FAM124B FAM126B FAM184A FAM193B FAM207A FAM214A FAM50B FAM90A1 FBF1 FBXL18 FBXO28 FIP1L1 GATA2 GATAD2B GCC1 GEM GFAP GLYCTK GNG5 GORASP1 GORASP2 GPANK1 GPKOW GPS2 GSE1 GTPBP10 GZMA GZMK HAUS1 HDAC4 HOXB9 HRASLS5 HTRA1 HYLS1 IFT20 IFT27 INPP5J IQCE ISCU ITPKB ITSN2 KANK2 KANSL1 KAT5 KDM1A KIAA1217 KIFC3 KRT18 KRT6A KRT6B KRT6C LASP1 LATS1 LCOR LCP2 LENG1 LGALS3 LIMS2 LIN7A LINGO1 LMO1 LMO2 LMO4 LYPLA1 LYSMD1 MAB21L2 MAGOH MAGOHB MBD3 MCM10 MCM7 MFAP1 MID2 MORF4L1 MORF4L2 MORN3 MOS MSRB3 MTFR2 MVP MYEF2 NCF2 NDE1 NDEL1 NDN NEBL NME7 NOS3 NUDT21 NXT2 ORC1 PARD6B PATL1 PIAS2 PID1 PIK3R2 PIN1 PKN1 PKP4 POLDIP3 POM121 PPP1R16B PPP1R18 PPP2CA PQBP1 PRKAA1 PRKAB2 PRPF31 PSMA1 PSMA4 RAB1A RAB1B RAB2A RAB2B RAB33B RAB39A RAB39B RAB6A RBL1 RBM17 RBM39 RBM41 RCOR3 RGS8 RHNO1 RIBC1 RITA1 RNF135 RNF213 RNF214 RSPH14 RSRC2 RTP5 RUSC2 SAMD4A SAP30BP SCAF8 SCEL SCNM1 SECISBP2 SELV SH2D4A SH3RF2 SHC3 SLU7 SMARCE1 SMCP SNAP47 SNF8 SNRPB SNRPB2 SNRPC SNTA1 SNW1 SPATA2 SPATA22 SRSF2 STAMBPL1 STK25 STK26 SYT6 TBP TCEA2 TCEANC TCF19 TCL1A TEAD4 TFAP4 THAP7 TMED2 TPM1 TPX2 TRIM29 TRIM42 TSC22D4 TSSC4 TSSK3 TTC23 TTC25 TTC9C TUBGCP4 TXLNA UBE2I UBE2U UBE3C USO1 USP2 UTP14C VPS28 VPS37C WDYHV1 YTHDC1 ZBTB16 ZFC3H1 ZFP2 ZFYVE26 ZGPAT ZMAT2 ZNF124 ZNF250 ZNF410 ZNF414 ZNF417 ZNF488 ZNF572 ZNF581 ZNF587 ZNF594 ZNF774	109 interactors: ACTN1 AGFG1 ANKRD17 ANXA7 AP2B1 ARHGEF4 AXIN1 AXIN2 BUB1 BUB1B C4A CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CSNK2A1 CTBP1 CTNNA1 CTNNB1 CYTH2 DLG3 DLGAP1 DST EPAS1 ERBB2IP EXPH5 FAM214A FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HSPA5 HTRA2 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT19 KRT23 KRT5 LAMA3 LAMA4 LPHN1 MACF1 MAPRE1 MAPRE2 MBD5 MCM3AP MUC1 MYH10 MYH11 MYO6 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L ND4 NEB NOSTRIN NUP153 NUP214 NUP54 NUP98 NUPL1 NUPL2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PRKACA PSMD1 PTPN13 RANBP9 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 SYNE1 TAF1 TFAP2A TPR TRIM21 TUBA4A XPO1 YWHAQ ZNF106
Entrez ID		2801	324
HPRD ID		03989	01439
Ensembl ID		ENSG00000167110	ENSG00000134982
Uniprot IDs		Q08379	B7Z2B6 P25054 Q4LE70
PDB IDs			1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Organelle Organization Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Metabolic Process MRNA Processing RNA Splicing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle RNA Processing Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Regulation Of Cellular Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Rab Protein Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Cell Cycle Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Process Phagosome Maturation Chromosome Organization Cellular Component Assembly Chromatin Modification Chromatin Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Phase Transition	Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Cell Cycle Process Protein Localization Cell Cycle Process Cellular Localization Mitotic Nuclear Envelope Disassembly Cellular Protein Localization Establishment Of Localization In Cell MRNA Transport Nuclear Envelope Disassembly Nucleus Organization Nuclear Envelope Organization Endomembrane System Organization RNA Transport Membrane Organization Viral Process RNA Localization Cellular Component Assembly Nucleocytoplasmic Transport Nuclear Transport Response To Stimulus Signaling Intracellular Transport Cell Communication Signal Transduction Regulation Of Cellular Component Organization Establishment Of Protein Localization Cytoplasmic Transport Anatomical Structure Development Cytoskeleton Organization Regulation Of Cell Cycle Viral Transcription Cell Differentiation Regulation Of Glucose Transport Protein Transport Developmental Process Viral Life Cycle Regulation Of Protein Catabolic Process Glucose Transport Cell Development Positive Regulation Of Wnt Signaling Pathway Hexose Transport Cellular Response To Stimulus Protein Localization To Organelle Negative Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cellular Process Cell Junction Assembly
Tagcloud ?		5p accounts ameliorated ap1 canx chaperones clamp decoy deleterious deregulation disturbances electrical eliminated erg forced former h2o2 hek293 hsc70 micrornas mirnas myocytes patch reciprocal record seed sequestration trafficking upregulation	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		5p accounts ameliorated ap1 canx chaperones clamp decoy deleterious deregulation disturbances electrical eliminated erg forced former h2o2 hek293 hsc70 micrornas mirnas myocytes patch reciprocal record seed sequestration trafficking upregulation	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?