GOLGA2 and PTPN11

Number of citations of the paper that reports this interaction (PubMedID 27229929)
45

Data Source:
BioGRID (two hybrid)

		GOLGA2	PTPN11
Description		golgin A2	protein tyrosine phosphatase non-receptor type 11
Image
GO Annotations	Cellular Component	Golgi Cis Cisterna Golgi Membrane Spindle Pole Cytoplasm Golgi Apparatus Cis-Golgi Network Cytoskeleton Microtubule Membrane COPII-coated ER To Golgi Transport Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Mitotic Spindle	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding Syntaxin Binding Identical Protein Binding Cadherin Binding Importin-alpha Family Protein Binding	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Protein Binding Hydrolase Activity Protein Kinase Binding Signaling Receptor Complex Adaptor Activity Receptor Tyrosine Kinase Binding Cadherin Binding Cell Adhesion Molecule Binding Peptide Hormone Receptor Binding Molecular Adaptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Protein Glycosylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule Nucleation Golgi Organization Centrosome Cycle Asymmetric Cell Division Negative Regulation Of Autophagy Protein Transport Negative Regulation Of Protein Binding Spindle Assembly Protein Homotetramerization Cell Division Positive Regulation Of Protein Glycosylation Golgi Ribbon Formation Golgi Disassembly Meiotic Spindle Assembly Mitotic Spindle Assembly	DNA Damage Checkpoint Signaling Neutrophil Activation Involved In Immune Response Lipid Metabolic Process Triglyceride Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axonogenesis Brain Development Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Hormone-mediated Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Cerebellar Cortex Formation Platelet Formation T Cell Costimulation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Microvillus Organization Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Cell Adhesion Mediated By Integrin Multicellular Organism Growth Organ Growth Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Atrioventricular Canal Development ERBB Signaling Pathway Negative Regulation Of T Cell Proliferation Vasodilation Hormone Metabolic Process Glucose Homeostasis Regulation Of Protein-containing Complex Assembly Regulation Of MAPK Cascade Positive Regulation Of Ossification Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Regulation Of Protein Export From Nucleus Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Genitalia Development Inner Ear Development Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Cortisol Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bergmann Glial Cell Differentiation Negative Regulation Of Growth Hormone Secretion Face Morphogenesis Regulation Of Type I Interferon-mediated Signaling Pathway Intestinal Epithelial Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Neutrophil Activation
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Interleukin-6 signaling PI3K Cascade MAPK3 (ERK1) activation MAPK1 (ERK2) activation GPVI-mediated activation cascade Prolactin receptor signaling PIP3 activates AKT signaling Spry regulation of FGF signaling Signaling by SCF-KIT GAB1 signalosome Downstream signal transduction PECAM1 interactions Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer Signaling by Leptin Co-inhibition by CTLA4 Co-inhibition by PD-1 Signal regulatory protein family interactions Netrin mediated repulsion signals Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of IFNG signaling RET signaling Interleukin-20 family signaling MET activates PTPN11 Regulation of RUNX1 Expression and Activity Interleukin-37 signaling Activated NTRK2 signals through FRS2 and FRS3 Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants SARS-CoV-2 activates/modulates innate and adaptive immune responses Co-inhibition by BTLA
Drugs			Dodecyltrimethylammonium
Diseases			Metachondromatosis Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Adult body size ( 32376654) Body mass index ( 26426971)	Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Apolipoprotein A1 levels ( 32203549) Blood pressure ( 21572416) Body mass index ( 26426971) Diastolic blood pressure ( 26390057) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Glycated hemoglobin levels ( 34059833) HDL cholesterol levels ( 32203549) Hematological parameters ( 19820697) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 22493691) Low HDL-cholesterol levels ( 31006500) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Peripheral artery disease ( 31285632) Platelet count ( 32888494 22139419) Reaction time ( 29844566) Response to alcohol consumption (flushing response) ( 29460428) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 30423114 24390342) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Systolic blood pressure ( 26390057 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 17554300) Urate levels ( 23263486) Waist-to-hip ratio adjusted for BMI ( 34054925)
Interacting Genes		465 interacting genes: ABHD17A ABLIM1 ADAP1 AFF4 AIRIM ALKBH2 ALKBH3 AMOTL2 ANKHD1 ANKRD11 ANKRD36 ANKRD36BP1 ANKS1A APC AQP1 ARFIP2 ARHGAP45 ARHGEF6 ARID5A ARL16 ARL4A ARNT2 ARPC3 ATOSA ATOSB ATP5PO ATP6V1C2 ATP6V1D ATP6V1G1 ATXN7 AXIN1 BAHD1 BARD1 BAZ2B BCAS2 BCL6 BCL6B BMS1P1 BYSL C12orf50 C19orf44 C1orf35 CAB39 CAPN7 CATSPERT CBX8 CBY2 CCAR1 CCDC120 CCDC13 CCDC146 CCDC150 CCDC17 CCDC185 CCDC187 CCDC198 CCDC70 CCDC87 CCDC92 CCHCR1 CCNC CCNH CDC20B CDC37 CDC5L CDC7 CDC73 CDCA7L CDK1 CDK18 CDKL3 CDKN1A CENPP CEP55 CEP57L1 CEP95 CHCHD2 CHCHD3 CIC CINP CKB CLIP3 COG6 CORO1A COX5B CRACR2A CRMP1 CSPP1 CSTF2T CUL5 CWF19L2 CYB5R2 DAXX DCTN4 DCX DDX6 DEUP1 DGCR6 DLG4 DLGAP3 DLGAP5 DLX6-AS1 DMTN DNM2 DRC4 DTX2 DVL2 EAF2 EFCAB6 EFHC1 EGR2 EIF3G EIF4A2 ENKD1 ENPP7 EP300 ERCC3 ESCO2 EXOC8 EXOSC5 FAM110A FAM124B FAM161A FAM161B FAM184A FAM193B FAM50B FAM90A1 FANCG FBF1 FBXL18 FBXO28 FIP1L1 FNDC11 FOXC2 FOXP1 FXR1 FXR2 GADD45GIP1 GAS2L2 GATA1 GATA2 GATAD2B GCC1 GEM GFAP GGA2 GGN GLYCTK GMCL1 GNG5 GNL3L GORASP1 GORASP2 GPANK1 GPKOW GPS2 GRAP2 GRB14 GSE1 GTPBP10 GZMA GZMK HAUS1 HDAC4 HGS HOXB5 HOXB9 HTRA1 HYCC2 HYLS1 IFT20 IFT27 IGFN1 IHO1 IKZF3 IL16 INPP5J IQCE IQUB ISCU ITGB5 ITPKB ITSN2 KANK2 KANSL1 KAT5 KDM1A KIAA1217 KIFC3 KRT1 KRT18 KRT6A KRT6B KRT6C KRT75 L3MBTL2 LASP1 LATS1 LCOR LCP2 LENG1 LGALS3 LHX4 LIMS2 LIN7A LINGO1 LMNB2 LMO1 LMO2 LMO3 LMO4 LYPLA1 LYSMD1 MAB21L2 MAGOH MAGOHB MBD3 MCM10 MCM7 MCRS1 MFAP1 MID2 MISP MNAT1 MORF4L1 MORF4L2 MORN3 MOS MSRB3 MTFR2 MVP MYEF2 NCF2 NDC80 NDE1 NDEL1 NDN NDUFA5 NEBL NECAB2 NEFL NME7 NOS3 NOTCH1 NSMF NTAQ1 NUDT21 NXT2 OAS1 ODAD4 ORC1 PACRGL PARD6B PATL1 PCM1 PIAS2 PIBF1 PID1 PIK3R2 PIMREG PIN1 PITX1 PKN1 PKN3 PKP1 PKP2 PKP4 PLAAT5 PLEKHA2 POLDIP3 POLR3C POM121 POU4F3 PPP1R16B PPP1R18 PPP2CA PQBP1 PRAM1 PRKAA1 PRKAA2 PRKAB2 PRPF18 PRPF3 PRPF31 PSMA1 PSMA4 PTBP2 PTPN11 PTPN21 RAB1A RAB1B RAB2A RAB2B RAB33B RAB39A RAB39B RAB6A RAD18 RAMAC RANBP3 RANBP3L RBL1 RBM17 RBM22 RBM25 RBM39 RBM41 RCL1 RCOR3 RGS8 RHNO1 RHOJ RIBC1 RIN1 RITA1 RNF135 RNF169 RNF213 RNF214 RNF6 RSPH14 RSRC2 RTP5 RUSC2 RXRB SAMD4A SAP30BP SAXO4 SCAF8 SCEL SCNM1 SECISBP2 SELENOV SFI1 SH2D4A SH3GLB2 SH3RF2 SHC3 SHISA6 SLU7 SLX9 SMARCB1 SMARCE1 SMCP SMG9 SNAP47 SNF8 SNRPB SNRPB2 SNRPC SNTA1 SNW1 SNX18 SORBS2 SPATA18 SPATA2 SPATA22 SPG21 SRSF2 SSX2IP STAC STAMBPL1 STK25 STK26 STN1 SUDS3 SUGP2 SUPT5H SYNPO2L SYT17 SYT6 TBC1D22B TBC1D30 TBP TCEA2 TCEANC TCF19 TCL1A TDP2 TEAD4 TEPSIN TEX9 TFAP4 TFIP11 THAP7 THYN1 TLE5 TMED2 TPM1 TPRX1 TPX2 TRAF1 TRAF3IP2 TRAF4 TRAF5 TRIM14 TRIM29 TRIM42 TSC1 TSC22D4 TSGA10 TSGA10IP TSHZ2 TSHZ3 TSSC4 TSSK3 TTC23 TTC9C TTPA TUBGCP4 TXLNA TXLNB UBE2H UBE2I UBE2U UBE3C UBTFL1 USO1 USP15 USP2 UTP14C UTP23 VPS28 VPS37C WASHC3 WHRN WT1 XIAP YJU2 YTHDC1 ZBTB16 ZBTB4 ZBTB42 ZC2HC1C ZFC3H1 ZFHX3 ZFP2 ZFYVE26 ZG16B ZGPAT ZMAT1 ZMAT2 ZNF124 ZNF250 ZNF280C ZNF3 ZNF35 ZNF410 ZNF414 ZNF417 ZNF438 ZNF48 ZNF488 ZNF512B ZNF524 ZNF572 ZNF581 ZNF587 ZNF594 ZNF648 ZNF688 ZNF774 ZNF835 ZZZ3	167 interacting genes: AATK ACTN4 AKT1 ALK AR ARHGAP1 AXL BCR BDKRB2 BEX1 BEX2 BLZF1 BTLA CALR CAT CAV1 CBL CCKBR CD33 CDC73 CDH5 CEACAM1 CHUK CRKL CSF2RB CSF3R CTDSP1 CTLA4 CXCR4 DAB1 DDR1 DMRTC1 EGFR EPHA1 EPHA2 EPOR ERBB2 ERBB3 ERBB4 FCGR1BP FCGR2B FCRL3 FGFR2 FGFR4 FLT1 FLT3 FLT4 FRS2 FRS3 FYN GAB1 GAB2 GAB3 GARIN5A GHR GMNN GOLGA2 GRB2 GRIN2B GTF2A2 HNRNPU HSP90B1 HSPA5 HSPA9 HSPD1 IFNAR1 IFNGR1 IGF1R IL4R IL6ST ILK INPP5D INSR IRS1 IRS2 IRS4 JAK1 JAK2 KDR KIR2DL5A KIT KLRC1 LAIR1 LCK LEPR LIFR LILRB4 LINC01558 LINC02907 LNX1 LRP1 MAP3K4 MAP3K5 MAPK3 MAPT MET MPIG6B MPL MPZL1 MS4A2 MVP NEB NEDD9 NOX4 NSUN5 NSUN5P2 NTRK1 NTRK2 ORMDL3 PAG1 PDGFRA PDGFRB PECAM1 PIK3CA PIK3CG PIK3R1 PILRA PILRB PLCG1 PNCK POU2AF1 PRKCA PRKCB PRKCH PRLR PTK2 PTK2B PTK7 PTPN6 PXN RANGRF RET ROR2 ROS1 RPIA SELE SERF2 SERPINF1 SHC1 SIGLEC11 SIGLEC12 SIGLEC7 SIRPA SIT1 SLAMF1 SLAMF6 SLC38A1 SLN SOCS3 SOS1 SPRY2 SRC SRSF10 STAT1 STAT3 STAT5A STAT5B SYNCRIP TEK TIE1 TLK1 TNFRSF1A TREML1 TRIM32 TRMT2B TSC2 TXNIP
Entrez ID		2801	5781
HPRD ID		03989	01470
Ensembl ID		ENSG00000167110	ENSG00000179295
Uniprot IDs		A0A8I5KNZ1 A0A8I5KZ68 A0A8I5QJQ7 A0A8J9BZL8 Q08379	Q06124
PDB IDs		4REY 6IW8 6IWA 6K06	2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 3ZM0 3ZM1 3ZM2 3ZM3 4DGP 4DGX 4GWF 4H1O 4H34 4JE4 4JEG 4JMG 4NWF 4NWG 4OHD 4OHE 4OHH 4OHI 4OHL 4PVG 4QSY 4RDD 5BK8 5DF6 5EHP 5EHR 5I6V 5IBM 5IBS 5X7B 5X94 5XZR 6ATD 6BMR 6BMU 6BMV 6BMW 6BMX 6BMY 6BN5 6CMP 6CMQ 6CMR 6CMS 6CRF 6CRG 6MD7 6MD9 6MDA 6MDB 6MDC 6MDD 6R5G 6WU8 7EMN 7JVM 7JVN 7R75 7R7D 7R7I 7R7L 7RCT 7TVJ 7VXG 7XHQ 8B5Y 8CBH 8GWW 8RZW 8RZY 8S01 8S04 8S06 8S07 8S0H 8S0I 8S0J 8S0K 8S0O 8S0P 8S0Q 8S0S 8T6D 8T6G 8T7Q 8T8Q 8U7W 8U7X 8WFY 8WX7 9BLG
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Nucleoplasm Centrosome Cytoskeleton Spliceosomal Complex Nuclear Speck MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Cytoplasm MRNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Organelle Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Androgen Receptor Binding RNA Metabolic Process Microtubule-based Process Zinc Ion Binding Regulation Of Primary Metabolic Process Spindle Pole Regulation Of Transcription By RNA Polymerase II Ciliary Basal Body Cytoskeleton Organization Centriole Organelle Assembly Negative Regulation Of RNA Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nuclear Export Regulation Of Macromolecule Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Intermediate Filament Organization Intermediate Filament Bundle Assembly Regulation Of Gene Expression Regulation Of Metabolic Process RNA Processing Negative Regulation Of Macromolecule Metabolic Process Cilium Organization Nucleobase-containing Compound Metabolic Process Golgi Organization U2-type Catalytic Step 2 Spliceosome	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Plasma Membrane Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Apoptotic Process Protein Phosphorylation Positive Regulation Of Locomotion Phosphorylation Regulation Of Developmental Process Protein Autophosphorylation Protein Phosphatase Binding Regulation Of Cell Migration Regulation Of Multicellular Organismal Development ATP Binding Regulation Of Cell Motility Regulation Of Immune System Process Regulation Of Cell Adhesion Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Developmental Process Immune System Process Cell Migration Positive Regulation Of Developmental Process
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