GNB2 and CAPNS1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GNB2	CAPNS1
Description		G protein subunit beta 2	calpain small subunit 1
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Vesicle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Calpain Complex
	Molecular Function	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding GTPase Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Degradation of the extracellular matrix Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs			PD150606
Diseases
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693)
Interacting Genes		32 interacting genes: ANXA7 ATXN10 CAPNS1 CDKN1A CFTR CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 ID3 MTNR1B NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1	21 interacting genes: AGTRAP ARHGEF6 ARR3 ATP5MF CAPN1 CAPN2 CAST CDC42 CDK4 DRG1 F2RL1 GET4 GNB2 IL2RG KCTD7 LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5
Entrez ID		2783	826
HPRD ID		11820	00240
Ensembl ID		ENSG00000172354	ENSG00000126247
Uniprot IDs		P62879 Q6FHM2	A0A0C4DGQ5 P04632
PDB IDs		9AVL	1KFU 1KFX 4PHJ 4PHK 4PHM 4WQ2 4WQ3 5D69 6QLB
Enriched GO Terms of Interacting Partners?		Heterotrimeric G-protein Complex G-protein Beta-subunit Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Signal Transduction Plasma Membrane Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Cell Division Membrane Response To Alcohol Negative Regulation Of Adenylate Cyclase Activity Regulation Of Programmed Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Synapse Ciliary Basal Body Wound Healing Cellular Response To Forskolin G Protein-coupled Receptor Binding Midbody Response To Forskolin Positive Regulation Of Programmed Cell Death PDZ Domain Binding Response To Wounding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Ketone Hematopoietic Or Lymphoid Organ Development Regulation Of Apoptotic Process Regulation Of Steroid Metabolic Process	Calpain Complex Calcium-dependent Cysteine-type Endopeptidase Activity Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Endocytosis Thioesterase Binding Positive Regulation Of Phagocytosis Positive Regulation Of Interleukin-8 Production Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Cytosol Pseudopodium Regulation Of Interleukin-8 Production Cytoplasm Positive Regulation Of Cellular Component Organization Regulation Of Phagocytosis GTPase Activity Regulation Of Endocytosis LncRNA Binding Regulation Of Interleukin-6 Production Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Establishment Of Endothelial Barrier Positive Regulation Of Interleukin-10 Production Endothelial Cell Development Positive Regulation Of Renin Secretion Into Blood Stream Signal Transduction Involved In Regulation Of Gene Expression Temperature Homeostasis Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly
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