GNB2 and ATXN10

Number of citations of the paper that reports this interaction (PMID 16498633)
5

Data Source:
BioGRID (pull down, pull down)
HPRD (two hybrid, in vitro, in vivo)

		GNB2	ATXN10
Gene Name		guanine nucleotide binding protein (G protein), beta polypeptide 2	ataxin 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Focal Adhesion Membrane Vesicle Protein Complex Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Signal Transducer Activity Calcium Channel Regulator Activity Protein Binding Protein Complex Binding GTPase Binding	Protein Binding Identical Protein Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Nervous System Development Neuron Projection Development
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ANXA7 ATXN10 CAPNS1 CDKN1A CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 GSK3B ID3 NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1	8 interactors: ABCA1 FN1 GLS GNB1 GNB2 GOLGA1 MRPS16 PPP1R12A
Entrez ID		2783	25814
HPRD ID		11820	04624
Ensembl ID		ENSG00000172354	ENSG00000130638
Uniprot IDs		P62879 Q6FHM2	Q9UBB4
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Synaptic Transmission Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Peptide Hormone Cellular Response To Peptide Response To Peptide Cell-cell Signaling Response To Hormone Cellular Response To Hormone Stimulus Generation Of Precursor Metabolites And Energy Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signal Transduction Response To Organic Substance G-protein Coupled Receptor Signaling Pathway Signaling Cellular Response To Organic Substance Cell Communication Cellular Response To Stimulus Response To Stimulus Regulation Of Cellular Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of Signal Transduction Cell Cycle Regulation Of CAMP Biosynthetic Process Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Hemostasis Positive Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process	Cellular Response To Glucagon Stimulus Response To Glucagon Secretion By Cell Synaptic Transmission Energy Reserve Metabolic Process Secretion Regulation Of Myosin-light-chain-phosphatase Activity Calcium-independent Cell-matrix Adhesion Interleukin-1 Beta Secretion Cellular Response To Acid Chemical Platelet Activation Glutamine Catabolic Process Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Glutamate Biosynthetic Process Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Muscle Cell Apoptotic Process Establishment Of Localization In Cell Cell-cell Signaling Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Platelet Dense Granule Organization Integrin Activation Phospholipid Efflux Phagocytosis, Engulfment Energy Derivation By Oxidation Of Organic Compounds Regulation Of Respiratory Gaseous Exchange By Neurological System Process Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Cellular Response To Prostaglandin E Stimulus Cellular Response To Peptide Hormone Stimulus Small Molecule Metabolic Process G-protein Coupled Acetylcholine Receptor Signaling Pathway Cellular Response To Peptide Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Respiratory System Process Cellular Localization G-protein Coupled Receptor Signaling Pathway Cellular Response To Cholesterol Negative Regulation Of Macrophage Derived Foam Cell Differentiation Reverse Cholesterol Transport Response To Laminar Fluid Shear Stress Membrane Invagination Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux
Tagcloud ?		abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb1 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants	adca adcas arca ascertained ataxia ataxias attct connections cypriot depended drpla encompass geographical hereby pentanucleotide rarer repeat sca sca1 sca10 sca12 sca17 sca2 sca3 sca6 sca7 sca8 scas triplet
Tagcloud (Difference) ?		abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb1 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants	adca adcas arca ascertained ataxia ataxias attct connections cypriot depended drpla encompass geographical hereby pentanucleotide rarer repeat sca sca1 sca10 sca12 sca17 sca2 sca3 sca6 sca7 sca8 scas triplet
Tagcloud (Intersection) ?