GNB2 and ATXN10

Number of citations of the paper that reports this interaction (PubMedID 16498633)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo, two hybrid)

		GNB2	ATXN10
Description		G protein subunit beta 2	ataxin 10
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Vesicle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Space Cytoplasm Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Dendrite Midbody Ciliary Basal Body Cell Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding GTPase Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport	Nervous System Development Neuron Projection Development Regulation Of Cytokinesis Cell Division Cilium Assembly Plasma Membrane Bounded Cell Projection Organization
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693)	Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hip circumference ( 28552196) Waist circumference ( 28552196)
Interacting Genes		32 interacting genes: ANXA7 ATXN10 CAPNS1 CDKN1A CFTR CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 ID3 MTNR1B NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1	13 interacting genes: ABCA1 DSCR9 FN1 GLS GNB1 GNB2 GOLGA1 HSPB1 HTR6 LIMS1 MRPS16 OGT PTGER4
Entrez ID		2783	25814
HPRD ID		11820	04624
Ensembl ID		ENSG00000172354	ENSG00000130638
Uniprot IDs		P62879 Q6FHM2	Q9UBB4
PDB IDs		9AVL
Enriched GO Terms of Interacting Partners?		Heterotrimeric G-protein Complex G-protein Beta-subunit Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Signal Transduction Plasma Membrane Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Cell Division Membrane Response To Alcohol Negative Regulation Of Adenylate Cyclase Activity Regulation Of Programmed Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Synapse Ciliary Basal Body Wound Healing Cellular Response To Forskolin G Protein-coupled Receptor Binding Midbody Response To Forskolin Positive Regulation Of Programmed Cell Death PDZ Domain Binding Response To Wounding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Ketone Hematopoietic Or Lymphoid Organ Development Regulation Of Apoptotic Process Regulation Of Steroid Metabolic Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus G Protein-coupled Receptor Signaling Pathway Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex Synapse GTPase Binding Sphingolipid Floppase Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Eosinophil Extravasation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Response To Alcohol Signal Transduction Response To Vitamin B3 Perinuclear Region Of Cytoplasm Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Plasma Membrane Positive Regulation Of Gene Expression Negative Regulation Of Eosinophil Migration
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