GNB2 and GNG13

Number of citations of the paper that reports this interaction (PMID 11675383)
9

Data Source:
HPRD (in vitro, in vivo)

		GNB2	GNG13
Gene Name		guanine nucleotide binding protein (G protein), beta polypeptide 2	guanine nucleotide binding protein (G protein), gamma 13
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Focal Adhesion Membrane Vesicle Protein Complex Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity Calcium Channel Regulator Activity Protein Binding Protein Complex Binding GTPase Binding	Signal Transducer Activity G-protein Beta-subunit Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Energy Reserve Metabolic Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Small Molecule Metabolic Process Sensory Perception Of Taste Cellular Response To Glucagon Stimulus
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes Peptide hormone metabolism Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation ADP signalling through P2Y purinoceptor 12 G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Incretin synthesis, secretion, and inactivation Prostacyclin signalling through prostacyclin receptor Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ANXA7 ATXN10 CAPNS1 CDKN1A CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 GSK3B ID3 NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1	9 interactors: DLG1 DLG4 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 LIN7B
Entrez ID		2783	51764
HPRD ID		11820	12116
Ensembl ID		ENSG00000172354	ENSG00000127588
Uniprot IDs		P62879 Q6FHM2	Q9P2W3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Synaptic Transmission Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Peptide Hormone Cellular Response To Peptide Response To Peptide Cell-cell Signaling Response To Hormone Cellular Response To Hormone Stimulus Generation Of Precursor Metabolites And Energy Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signal Transduction Response To Organic Substance G-protein Coupled Receptor Signaling Pathway Signaling Cellular Response To Organic Substance Cell Communication Cellular Response To Stimulus Response To Stimulus Regulation Of Cellular Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of Signal Transduction Cell Cycle Regulation Of CAMP Biosynthetic Process Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Hemostasis Positive Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process	Cellular Response To Glucagon Stimulus Response To Glucagon Cell-cell Signaling Synaptic Transmission Establishment Or Maintenance Of Apical/basal Cell Polarity Energy Reserve Metabolic Process Maintenance Of Apical/basal Cell Polarity Signaling Receptor Localization To Synapse Energy Derivation By Oxidation Of Organic Compounds Cell Communication Cellular Response To Peptide Hormone Stimulus Detection Of Visible Light Cellular Response To Peptide Response To Organonitrogen Compound Detection Of Light Stimulus Maintenance Of Cell Polarity Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Protein Localization To Synapse Response To Peptide Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity G-protein Coupled Receptor Signaling Pathway Detection Of Abiotic Stimulus Establishment Or Maintenance Of Cell Polarity Regulation Of Rhodopsin Mediated Signaling Pathway Cortical Actin Cytoskeleton Organization Cellular Response To Hormone Stimulus Cortical Cytoskeleton Organization Rhodopsin Mediated Signaling Pathway Small Molecule Metabolic Process Receptor Clustering Nucleotide Phosphorylation Response To Light Stimulus Sensory Perception Of Taste Response To External Stimulus Response To Hormone Protein Localization To Membrane Phototransduction, Visible Light Regulation Of Ion Transmembrane Transport Response To Radiation Cellular Response To Light Stimulus Phototransduction Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Detection Of Stimulus Response To Organic Substance Cellular Response To Radiation Response To Stimulus
Tagcloud ?		abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb1 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Difference) ?		abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb1 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Intersection) ?