GNB2 and STAT5A

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GNB2	STAT5A
Gene Name		guanine nucleotide binding protein (G protein), beta polypeptide 2	signal transducer and activator of transcription 5A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Focal Adhesion Membrane Vesicle Protein Complex Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm Cytosol
	Molecular Function	GTPase Activity Signal Transducer Activity Calcium Channel Regulator Activity Protein Binding Protein Complex Binding GTPase Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Allantoin Metabolic Process Luteinization Natural Killer Cell Differentiation Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process JAK-STAT Cascade Female Pregnancy Lactation Peptidyl-tyrosine Phosphorylation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Positive Regulation Of Natural Killer Cell Differentiation Negative Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Positive Regulation Of Mast Cell Differentiation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Mammary Gland Epithelium Development Positive Regulation Of Mast Cell Proliferation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		31 interactors: ANXA7 ATXN10 CAPNS1 CDKN1A CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 GSK3B ID3 NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1	72 interactors: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK LEF1 MAGEA12 MAPK1 MAPK3 MRPS6 NARF NCOR2 NLK NMI NR3C1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TSLP TXNDC11 UGT2B4 WASH2P ZNF596
Entrez ID		2783	6776
HPRD ID		11820	03301
Ensembl ID		ENSG00000172354	ENSG00000126561
Uniprot IDs		P62879 Q6FHM2	A8K6I5 K7EK35 P42229 Q59GY7
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Synaptic Transmission Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Peptide Hormone Cellular Response To Peptide Response To Peptide Cell-cell Signaling Response To Hormone Cellular Response To Hormone Stimulus Generation Of Precursor Metabolites And Energy Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signal Transduction Response To Organic Substance G-protein Coupled Receptor Signaling Pathway Signaling Cellular Response To Organic Substance Cell Communication Cellular Response To Stimulus Response To Stimulus Regulation Of Cellular Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of Signal Transduction Cell Cycle Regulation Of CAMP Biosynthetic Process Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Hemostasis Positive Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process	Cellular Response To Organic Substance Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Hormone Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Protein Autophosphorylation Cellular Response To Stimulus Immune Response Signal Transduction Immune System Process Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Cellular Response To Cytokine Stimulus Regulation Of Immune Response Defense Response Response To Cytokine Positive Regulation Of Cellular Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Peptidyl-amino Acid Modification Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Cellular Response To Growth Hormone Stimulus Innate Immune Response Cellular Response To Peptide Response To Organonitrogen Compound Regulation Of Immune System Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Organ Development Response To Growth Factor Cytokine-mediated Signaling Pathway JAK-STAT Cascade Regulation Of MAPK Cascade Response To Peptide Hormone Neurotrophin TRK Receptor Signaling Pathway Response To Peptide Fc Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity Response To Growth Hormone Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Anatomical Structure Development
Tagcloud ?		abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb1 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants	advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely
Tagcloud (Difference) ?		abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb1 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants	advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely
Tagcloud (Intersection) ?