ADRA1B and AP2M1

Number of citations of the paper that reports this interaction (PMID 12644451)
15

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ADRA1B	AP2M1
Gene Name		adrenoceptor alpha 1B	adaptor-related protein complex 2, mu 1 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane	Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Alpha1-adrenergic Receptor Activity Protein Heterodimerization Activity	Signal Sequence Binding Transporter Activity Protein Binding Lipid Binding Clathrin Adaptor Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Blood Vessel Remodeling Response To Amphetamine Vasoconstriction Of Artery Involved In Baroreceptor Response To Lowering Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Adult Heart Development Locomotory Behavior Cell Proliferation Visual Learning Cell Growth Regulation Of Vasoconstriction Organ Growth Intracellular Signal Transduction Glucose Homeostasis Response To Morphine Positive Regulation Of MAPK Cascade Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycogen Catabolic Process Behavioral Response To Cocaine Regulation Of Cardiac Muscle Contraction Adrenergic Receptor Signaling Pathway	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Membrane Organization Clathrin-mediated Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Adrenoceptors G alpha (12/13) signalling events	Retrograde neurotrophin signalling Axon guidance Gap junction degradation HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Formation of annular gap junctions Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Nef mediated downregulation of CD28 cell surface expression Gap junction trafficking Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs		Midodrine Ziprasidone Dapiprazole Olanzapine Alfuzosin Clozapine Norepinephrine Phenylephrine Promazine Prazosin Chlorpromazine Doxazosin Labetalol Nicardipine Epinephrine Thioridazine Ergotamine Tamsulosin Methoxamine Trimipramine Risperidone Modafinil Propiomazine Doxepin Nefazodone Terazosin Pergolide Bromocriptine Quetiapine Aripiprazole Lisdexamfetamine Paliperidone Methotrimeprazine Dextroamphetamine Phendimetrazine Propericiazine Acepromazine Thioproperazine Dronedarone Sertindole Silodosin Droxidopa Xylometazoline
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		11 interactors: ADRA1A AP2M1 EZR FLNC GNA11 GNAQ NOS1 PPP1R9B PRKCA SAG STAT1	40 interactors: ADRA1B AP2B1 AQP4 ARRB2 ATXN1L CACNA1A CD22 CD3D CDK11B CORO7 CSNK2B CTLA4 DAB2 DCX DPPA2 DVL2 EHD2 FAM208A FURIN FXR2 GAK GRIN2B IKZF1 KCNJ11 LAMP1 LY9 MED4 MEGF10 NCOR2 NDRG1 RALBP1 RPL38 RRP12 RSPH14 RUNDC3A STON2 SYNJ1 TBC1D5 TGOLN2 ZBTB8A
Entrez ID		147	1173
HPRD ID		00080	03014
Ensembl ID			ENSG00000161203
Uniprot IDs		P35368	E9PFW3 Q96CW1
PDB IDs			1H6E
Enriched GO Terms of Interacting Partners?		Regulation Of The Force Of Heart Contraction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To External Stimulus Developmental Process Positive Regulation Of Phospholipase Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Melanocyte Differentiation Negative Regulation Of Catalytic Activity Cell Differentiation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Filopodium Assembly Regulation Of Epithelial Cell Differentiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signal Transduction Regulation Of Muscle Contraction Regulation Of Developmental Pigmentation Regulation Of Heart Contraction Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Intracellular Signal Transduction Signaling Platelet Activation Rhodopsin Mediated Signaling Pathway System Development Cell Communication G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Negative Regulation Of Signaling Wound Healing Dopamine Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Locomotion Response To Stimulus Response To Wounding Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Multicellular Organismal Development Regulation Of Catalytic Activity Cellular Response To Stimulus	Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Regulation Of Cellular Process System Development Organ Development Endocytosis Signaling Regulation Of Endocytosis Cell Communication Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Transport Protein Localization Developmental Process Positive Regulation Of Transport Cellular Response To Transforming Growth Factor Beta Stimulus Signal Transduction Response To Transforming Growth Factor Beta Cell Differentiation Synaptic Transmission Cell Development Establishment Of Protein Localization Chemotaxis Neurological System Process Regulation Of Signaling Cell-cell Signaling Cellular Response To Stimulus Nervous System Development Positive Regulation Of Receptor Internalization Regulation Of Androgen Receptor Signaling Pathway Establishment Of Localization In Cell Cellular Localization Single-organism Behavior Tube Development Behavioral Response To Pain Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Morphogenesis Involved In Differentiation Cell Proliferation Regulation Of Metabolic Process Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Membrane Potential Tissue Development Response To Stimulus Response To Estradiol Brain Development Protein Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Receptor Internalization
Tagcloud ?		adrenergic agonists angiogenesis biodistribution chemokine cognate cxcr1 distributed gpcr gpcrs hemostasis intractable lipidated loops par1 pathophysiological penetrating pepducins pharmacodynamic pharmacokinetic pharmacology possess protease s1p3 sepsis sphingosine superfamily thrombosis vital	chemiluminescent chose escc ftl gearray gearrays gncpro guideline highlighted hla hspa8 immuno iran iranian locate mmp2 modalities modulatory northeast online prove rap1a tailed tp53i3 ube2l6 underexpressed verified verify xrcc5
Tagcloud (Difference) ?		adrenergic agonists angiogenesis biodistribution chemokine cognate cxcr1 distributed gpcr gpcrs hemostasis intractable lipidated loops par1 pathophysiological penetrating pepducins pharmacodynamic pharmacokinetic pharmacology possess protease s1p3 sepsis sphingosine superfamily thrombosis vital	chemiluminescent chose escc ftl gearray gearrays gncpro guideline highlighted hla hspa8 immuno iran iranian locate mmp2 modalities modulatory northeast online prove rap1a tailed tp53i3 ube2l6 underexpressed verified verify xrcc5
Tagcloud (Intersection) ?