ADRA1B and SAG

Number of citations: 0 (PubMedID 8617782)
Data Source: HPRD (in vivo)

		ADRA1B	SAG
Name		adrenoceptor alpha 1B	S-antigen visual arrestin
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Caveola Membrane Nuclear Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytosol Membrane Cell Projection
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity	G Protein-coupled Receptor Binding Opsin Binding Protein Phosphatase Inhibitor Activity Protein Binding Spectrin Binding Phosphoprotein Binding
	Biological Process	Regulation Of Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Regulation Of Vasoconstriction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Neuron-glial Cell Signaling	G Protein-coupled Receptor Internalization Signal Transduction Cell Surface Receptor Signaling Pathway Sensory Perception G Protein-coupled Opsin Signaling Pathway
Pathways		Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events	Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Dihydroergotamine Amitriptyline Olanzapine Alfuzosin Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Prochlorperazine Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Nortriptyline Amoxapine Clonidine Doxazosin Labetalol Nicardipine Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Modafinil Fenoldopam Dobutamine Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Mephentermine Methotrimeprazine Dextroamphetamine Dextroamphetamine Phendimetrazine Periciazine Acepromazine Thioproperazine Dronedarone R450 Epicept NP-1 Sertindole Mianserin Pizotifen Silodosin Ocaperidone Droxidopa Xylometazoline Tetryzoline Perospirone Brexpiprazole Dosulepin Viloxazine Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil	None
Diseases		None	Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP)
GWAS		Diastolic blood pressure ( 27841878 ) Plasma anti-thyroglobulin levels ( 29678681 ) Psoriatic arthritis ( 26626624 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 )	Calcium levels ( 20705733 ) Crohn's disease ( 22412388 ) Estimated glomerular filtration rate ( 31152163 ) Mild obesity-related type 2 diabetes ( 34737425 )
Novel Interactors		None recorded	1 novel interactors: EIF4E2
Interacting Genes		11 interacting genes: ADRA1A AP2M1 EZR FLNC GNA11 GNAQ NOS1 PPP1R9B PRKCA SAG STAT1	4 interacting genes: ADRA1B CHRM2 CLK3 RHO
Entrez ID		147	6295
HPRD ID		00080	01625
Ensembl ID		ENSG00000170214	ENSG00000130561
Uniprot IDs		P35368	P10523
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Response To Hormone Phototransduction System Process Receptor Internalization G Protein-coupled Receptor Binding Phospholipase C-activating Serotonin Receptor Signaling Pathway Detection Of Light Stimulus Photoreceptor Outer Segment Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Phototransduction, Visible Light Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Guanyl Nucleotide Binding Detection Of Abiotic Stimulus G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Binding Positive Regulation Of Transport G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Filopodium Assembly Signal Transduction Regulation Of The Force Of Heart Contraction Regulation Of Protein Localization To Cell Periphery Disordered Domain Specific Binding Positive Regulation Of Protein Localization Detection Of Visible Light Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To PH Response To Prostaglandin E Entrainment Of Circadian Clock Enzyme Regulator Activity Regulation Of Protein Localization Regulation Of Blood Pressure Regulation Of Protein Localization To Membrane Receptor-mediated Endocytosis Plasma Membrane Heterotrimeric G-protein Complex Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cellular Localization Actin Filament Binding Response To PH Blood Circulation Response To Ketone Acetylcholine Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway	Alpha1-adrenergic Receptor Activity Regulation Of Heart Contraction Regulation Of Muscle Contraction G Protein-coupled Receptor Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuron-glial Cell Signaling G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Activity Detection Of Temperature Stimulus Involved In Thermoception G Protein-coupled Opsin Signaling Pathway Rod Bipolar Cell Differentiation Photoreceptor Inner Segment Membrane 11-cis Retinal Binding Sperm Head Plasma Membrane Thermotaxis Absorption Of Visible Light MRNA Cap Binding Adrenergic Receptor Activity Regulation Of Blood Circulation Regulation Of Muscle System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Arrestin Family Protein Binding Retinal Bipolar Neuron Differentiation Photoreceptor Activity Podosome Assembly Rod Photoreceptor Outer Segment Cholinergic Synapse Photoreceptor Outer Segment Membrane G Protein-coupled Photoreceptor Activity Phototransduction, Visible Light RNA Cap Binding RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Golgi-associated Vesicle Membrane Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Light Intensity Glutamatergic Neuron Differentiation G Protein-coupled Acetylcholine Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Sensory Perception Photoreceptor Disc Membrane Translation Factor Activity, RNA Binding Adrenergic Receptor Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Detection Of Temperature Stimulus Detection Of Visible Light Protein Serine/threonine/tyrosine Kinase Activity