RND1 and GRB7

Number of citations of the paper that reports this interaction (PMID 10664463)
5

Data Source:
HPRD (two hybrid, in vitro)

		RND1	GRB7
Gene Name		Rho family GTPase 1	growth factor receptor-bound protein 7
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Adherens Junction	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection
	Molecular Function	GTPase Activity Receptor Binding Protein Binding GTP Binding	RNA Binding SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Actin Filament Organization Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Axon Guidance Metabolic Process Neuron Remodeling	Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Leukocyte Migration
Pathways		Axon guidance Semaphorin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Signaling by PDGF Signaling by SCF-KIT Signaling by ERBB2 Downstream signal transduction GRB7 events in ERBB2 signaling Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		12 interactors: ARHGAP5 CREB3L2 FRS2 FRS3 GRB7 ID3 PDE6D PLXNA1 PLXNB1 PLXNB2 UBXN11 ZNF212	39 interactors: A1BG AGAP1 ATP5B CALM1 CAV1 CPNE6 DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 FGB FLAD1 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MSH2 PDGFRB PDHB PHAX PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 TEK TLE1 TMSB4X TRIM36 ZBTB16
Entrez ID		27289	2886
HPRD ID		12357	03311
Ensembl ID		ENSG00000172602	ENSG00000141738
Uniprot IDs		Q92730	Q14451
PDB IDs		2CLS 2REX 3Q3J	1MW4 1WGR 2L4K 2QMS 3PQZ
Enriched GO Terms of Interacting Partners?		Semaphorin-plexin Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Organ Development Regulation Of Locomotion Neuroblast Proliferation Regulation Of Cellular Component Movement Regulation Of Rho GTPase Activity Regulation Of Rho Protein Signal Transduction Generation Of Neurons Positive Regulation Of Axonogenesis Response To Stimulus Stem Cell Proliferation Neurogenesis Tissue Development Signal Transduction Neural Precursor Cell Proliferation Epithelium Development Gland Development System Development Morphogenesis Of An Epithelium Signaling Optic Placode Formation Involved In Camera-type Eye Formation Cell Communication Regulation Of Ras GTPase Activity Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Optic Placode Formation Gland Morphogenesis Regulation Of Axonogenesis Regulation Of Cell Shape Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Cell Differentiation Nervous System Development Tissue Morphogenesis Multicellular Organismal Development Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Fibroblast Growth Factor Regulation Of Catalytic Activity Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Anatomical Structure Development Anatomical Structure Morphogenesis	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Immune System Process Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Wound Healing Immune Response-regulating Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Ketone Metabolic Process Regulation Of Catalytic Activity Regulation Of Immune System Process Regulation Of Signal Transduction Response To Wounding Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-amino Acid Modification Signal Transduction By Phosphorylation Positive Regulation Of Cellular Metabolic Process Response To Hormone Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		bioinformatics colonization conversely conversion cooperated deregulated derepression disrupted gap gtpase inactivates inactivation mechanistic mesenchymal neoplastic p120 plexin polarity rap1 rarely ras restrains rho signalling spontaneous suppresses turn unappreciated undifferentiated	adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Difference) ?		bioinformatics colonization conversion cooperated deregulated derepression disrupted gap gtpase inactivates inactivation mechanistic mesenchymal neoplastic p120 plexin polarity rap1 rarely ras restrains rho signalling spontaneous suppresses turn unappreciated undifferentiated	adapter appears avidly bear bps denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Intersection) ?		conversely