DOCK4

Name	dedicator of cytokinesis 4
Structure	No pdb structure
Interactors	4 interactors: ELMO2 FASLG GRB2 RNF115
GO Annotations	Cellular Component	Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Stereocilium Stereocilium Bundle Cell Projection Organelle Postsynapse Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding
	Biological Process	Small GTPase-mediated Signal Transduction Cell Chemotaxis Regulation Of Postsynapse Assembly Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways	RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production
GWAS	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Body mass index (change over time) ( 25378290 ) C-reactive protein and white blood cell count ( 22788528 ) DHEAS levels ( 34748635 ) Migraine ( 27322543 ) Mild age-related type 2 diabetes ( 34737425 ) Refractive astigmatism ( 30306274 ) Refractive error ( 32231278 ) Response to fenofibrate ( 22890011 ) Total intracranial volume ( 31530798 )
Entrez ID	9732
HPRD ID	07407
Ensembl ID	ENSG00000128512
Uniprot IDs	Q8N1I0
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway SH3 Domain Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Grb2-EGFR Complex Retinal Cell Programmed Cell Death Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Inflammatory Cell Apoptotic Process Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Positive Regulation Of Toll-like Receptor Signaling Pathway Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Immune Response-activating Signaling Pathway Regulation Of Plasma Membrane Organization Death Receptor Binding Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Endocytosis Insulin Receptor Substrate Binding Activation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Chloride Ion Homeostasis Schwann Cell Development Programmed Necrotic Cell Death Monoatomic Anion Homeostasis Immune System Process Programmed Cell Death Involved In Cell Development Negative Regulation Of Toll-like Receptor Signaling Pathway