DOCK4

Gene Name		dedicator of cytokinesis 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Endomembrane System Membrane Stereocilium Stereocilium Bundle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding PDZ Domain Binding Rac GTPase Activator Activity Receptor Tyrosine Kinase Binding Rac GTPase Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Rac GTPase Activity Cell Chemotaxis
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		C-reactive protein and white blood cell count ( 22788528) Response to fenofibrate ( 22890011)
Protein-protein Interactions		3 interactors: FASLG GRB2 RNF115
Entrez ID		9732
HPRD ID		07407
Ensembl ID		ENSG00000128512
Uniprot IDs		Q8N1I0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Endosomal Lumen Acidification Retinal Cell Programmed Cell Death Necroptotic Signaling Pathway Cellular Chloride Ion Homeostasis Inflammatory Cell Apoptotic Process Chloride Ion Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Signal Transduction Response To Growth Factor T Cell Apoptotic Process Regulation Of Signaling Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular PH Reduction PH Reduction Labyrinthine Layer Morphogenesis Positive Regulation Of ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Embryonic Placenta Morphogenesis Necroptotic Process Endosome Organization Protein K63-linked Ubiquitination Regulation Of Endothelial Cell Apoptotic Process Cell-cell Signaling Protein K48-linked Ubiquitination Developmental Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Receptor Internalization Protein Autoubiquitination Regulation Of Intracellular PH Programmed Necrotic Cell Death Anion Homeostasis Regulation Of Cellular PH Necrotic Cell Death Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Labyrinthine Layer Development Cellular Response To Ionizing Radiation Positive Regulation Of Neuron Apoptotic Process
Tagcloud ?		7q 7q22 advance advancement associate biology chromosome cloned commonly cytogenetic del deleted exhibiting ezh2 fish located malignancies mll5 monosomy monosomy7 myeloid samd9 samd9l segments speculating summaries suppressor susceptibility technologies