DOCK4 and RNF115

Number of citations of the paper that reports this interaction (PubMedID 22315970)
45

Data Source:
BioGRID (two hybrid)

		DOCK4	RNF115
Description		dedicator of cytokinesis 4	ring finger protein 115
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Stereocilium Stereocilium Bundle Cell Projection Organelle Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Small GTPase-mediated Signal Transduction Cell Chemotaxis Regulation Of Postsynapse Assembly Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Protein Polyubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Protein Ubiquitination Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index (change over time) ( 25378290) C-reactive protein and white blood cell count ( 22788528) DHEAS levels ( 34748635) Migraine ( 27322543) Mild age-related type 2 diabetes ( 34737425) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Response to fenofibrate ( 22890011) Total intracranial volume ( 31530798)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)
Interacting Genes		4 interacting genes: ELMO2 FASLG GRB2 RNF115	34 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MAVS MDM2 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A STING1 TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N USP9X VCP ZNRD2
Entrez ID		9732	27246
HPRD ID		07407	18328
Ensembl ID		ENSG00000128512	ENSG00000265491
Uniprot IDs		Q8N1I0	Q9Y4L5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway SH3 Domain Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Grb2-EGFR Complex Retinal Cell Programmed Cell Death Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Inflammatory Cell Apoptotic Process Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Positive Regulation Of Toll-like Receptor Signaling Pathway Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Immune Response-activating Signaling Pathway Regulation Of Plasma Membrane Organization Death Receptor Binding Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Endocytosis Insulin Receptor Substrate Binding Activation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Chloride Ion Homeostasis Schwann Cell Development Programmed Necrotic Cell Death Monoatomic Anion Homeostasis Immune System Process Programmed Cell Death Involved In Cell Development Negative Regulation Of Toll-like Receptor Signaling Pathway	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Nucleotide Binding Protein Metabolic Process Protein Monoubiquitination Protein Serine/threonine Kinase Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle G1/S Phase Transition Protein-containing Complex Positive Regulation Of Mitotic Cell Cycle Proteolysis Positive Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Intracellular Signal Transduction Immune Response-activating Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Enzyme Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cilium Assembly Protein K63-linked Ubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Immune Response-regulating Signaling Pathway Regulation Of Intracellular Signal Transduction Transferase Activity Activation Of Immune Response Protein K6-linked Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Traversing Start Control Point Of Mitotic Cell Cycle
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