RPL18A and MDK

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPL18A	MDK
Gene Name		ribosomal protein L18a	midkine (neurite growth-promoting factor 2)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Cytosolic Large Ribosomal Subunit	Extracellular Region Cytoplasm Cell Projection
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding	Growth Factor Activity Heparin Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Behavioral Fear Response Signal Transduction Notch Signaling Pathway Nervous System Development Short-term Memory Response To Wounding Cell Migration Dentate Gyrus Development Cerebellar Granular Layer Development Cerebral Cortex Development Cell Differentiation Adrenal Gland Development Defecation Response To Drug Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Signaling by NOTCH2 Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS			Immunoglobulin A ( 20694011)
Protein-Protein Interactions		10 interactors: AES JUN LPL MAP3K12 MDK NEDD4 RIBC2 RNF115 RPL36 TNK2	17 interactors: ALK JAK1 JAK2 LRP1 LRP2 MAPK6 NCL PTPRZ1 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TGM1 TSPAN1 UBQLN4
Entrez ID		6142	4192
HPRD ID		16045	01200
Ensembl ID		ENSG00000105640	ENSG00000110492
Uniprot IDs		B4DM94 Q02543	P21741
PDB IDs		3J3B	1MKC 1MKN
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Outflow Tract Morphogenesis Establishment Of Protein Localization To Organelle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Defecation Cellular Response To Potassium Ion Starvation Transmission Of Virus Development Involved In Symbiotic Interaction Protein Targeting Response To Radiation Response To Stress Signal Transduction Negative Regulation Of Binding Response To Drug Protein Localization To Organelle Leading Edge Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Response To Calcium Ion Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signaling Cell Communication Chylomicron Remodeling Positive Regulation Of Anoikis Regulation Of Signal Transduction Protein Polyubiquitination Cytoplasmic Transport Negative Regulation Of Neuron Apoptotic Process Response To Cytokine Progesterone Receptor Signaling Pathway Positive Regulation Of Monocyte Differentiation Positive Regulation Of Sequestering Of Triglyceride Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Negative Regulation Of Neuron Death Protein Autophosphorylation Cellular Response To Extracellular Stimulus Regulation Of Signaling Catabolic Process Heart Morphogenesis Cell Surface Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway SMAD Protein Import Into Nucleus Very-low-density Lipoprotein Particle Remodeling MAPK Cascade Cellular Macromolecule Catabolic Process	Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Extracellular Vesicular Exosome Assembly Response To Light Stimulus Protein Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Response To Radiation System Development Signal Transduction Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Stimulus Developmental Process Regulation Of Cytokine-mediated Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Signaling Cell Communication Response To Abiotic Stimulus Multicellular Organismal Development Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Transport Response To External Stimulus Growth Hormone Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Cellular Response To Interferon-gamma Cellular Response To Growth Hormone Stimulus Response To Interferon-gamma Glycoprotein Metabolic Process Glycosaminoglycan Metabolic Process Response To Toxic Substance Cellular Response To Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Pathogenesis
Tagcloud ?			aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic
Tagcloud (Difference) ?			aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic
Tagcloud (Intersection) ?