RPL18A and LPL

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPL18A	LPL
Gene Name		ribosomal protein L18a	lipoprotein lipase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Cytosolic Large Ribosomal Subunit	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Extracellular Matrix Anchored Component Of Membrane Very-low-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Receptor Binding Protein Binding Heparin Binding Triglyceride Binding Apolipoprotein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Retinoid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Phototransduction, Visible Light Response To Cold Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Positive Regulation Of Sequestering Of Triglyceride Triglyceride Biosynthetic Process Triglyceride Catabolic Process Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Response To Drug Small Molecule Metabolic Process Triglyceride Homeostasis
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Lipoprotein metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Transcriptional regulation of white adipocyte differentiation Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs			Tyloxapol
Diseases
GWAS			Cardiovascular disease risk factors ( 21943158) HDL cholesterol ( 23726366 20031538 21909109 18193043 18193044 20864672 19060906 19060911 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219 19936222) Metabolic syndrome ( 22399527 21386085 20694148) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Triglycerides ( 23726366 21909109 18193043 18193044 18193046 20864672 19060906 19060911 22171074 20139978 17463246 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		10 interactors: AES JUN LPL MAP3K12 MDK NEDD4 RIBC2 RNF115 RPL36 TNK2	16 interactors: APOC2 APP ASCC2 CALR CCND1 CETP COPS6 EMD KIAA1377 LRP1 LRP2 LUC7L2 PTPN4 RPL18A UBE2Z VLDLR
Entrez ID		6142	4023
HPRD ID		16045	01999
Ensembl ID		ENSG00000105640	ENSG00000175445
Uniprot IDs		B4DM94 Q02543	P06858
PDB IDs		3J3B
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Outflow Tract Morphogenesis Establishment Of Protein Localization To Organelle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Defecation Cellular Response To Potassium Ion Starvation Transmission Of Virus Development Involved In Symbiotic Interaction Protein Targeting Response To Radiation Response To Stress Signal Transduction Negative Regulation Of Binding Response To Drug Protein Localization To Organelle Leading Edge Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Response To Calcium Ion Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signaling Cell Communication Chylomicron Remodeling Positive Regulation Of Anoikis Regulation Of Signal Transduction Protein Polyubiquitination Cytoplasmic Transport Negative Regulation Of Neuron Apoptotic Process Response To Cytokine Progesterone Receptor Signaling Pathway Positive Regulation Of Monocyte Differentiation Positive Regulation Of Sequestering Of Triglyceride Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Negative Regulation Of Neuron Death Protein Autophosphorylation Cellular Response To Extracellular Stimulus Regulation Of Signaling Catabolic Process Heart Morphogenesis Cell Surface Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway SMAD Protein Import Into Nucleus Very-low-density Lipoprotein Particle Remodeling MAPK Cascade Cellular Macromolecule Catabolic Process	Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Response To Light Stimulus Regulation Of Cholesterol Transport Alcohol Metabolic Process Receptor-mediated Endocytosis Endocytosis Response To Radiation Regulation Of Plasma Lipoprotein Particle Levels Very-low-density Lipoprotein Particle Remodeling Phototransduction, Visible Light Retinoid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Reverse Cholesterol Transport Isoprenoid Metabolic Process Regulation Of Cholesterol Efflux Lipid Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Metabolic Process Plasma Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Vesicle-mediated Transport Triglyceride Homeostasis Plasma Lipoprotein Particle Clearance Acylglycerol Homeostasis Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Response To Abiotic Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Peptide Antigen Assembly With MHC Class I Protein Complex Beta-amyloid Clearance Positive Regulation Of Cell Cycle Cholesterol Transport Sterol Transport Lipid Transport Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Lipid Localization Cholesterol Homeostasis Sterol Homeostasis Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling
Tagcloud ?			8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally
Tagcloud (Difference) ?			8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally
Tagcloud (Intersection) ?