CST3 and PDZD2

Number of citations of the paper that reports this interaction (PMID 1731767)
15

Data Source:
HPRD (in vitro)

		CST3	PDZD2
Gene Name		cystatin C	PDZ domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cell-cell Junction
	Molecular Function	Beta-amyloid Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Defense Response Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Regulation Of Tissue Remodeling Extracellular Fibril Organization Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling	Cell Adhesion
Pathways		Amyloids
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Cystatin C ( 17903292)	Obesity-related traits ( 23251661) Renal cell carcinoma ( 23184150)
Protein-Protein Interactions		9 interactors: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115	5 interactors: BAI1 CST3 CTNND2 NRXN1 PKP4
Entrez ID		1471	23037
HPRD ID		05056	10142
Ensembl ID		ENSG00000101439	ENSG00000133401
Uniprot IDs		P01034	O15018
PDB IDs		1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA
Enriched GO Terms of Interacting Partners?		Cellular Response To Thyroid Hormone Stimulus Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Response To Thyroid Hormone Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Protein Catabolic Process Positive Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response Proteolysis Adaptive Immune Response Antigen Processing And Presentation Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Catabolic Process Immune System Process Immune Response-regulating Signaling Pathway Basement Membrane Disassembly Macrophage Apoptotic Process Adult Locomotory Behavior Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Hormone Stimulus Adult Behavior Myeloid Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Inflammatory Cell Apoptotic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Locomotory Behavior Regulation Of Apoptotic Cell Clearance Negative Regulation Of Endopeptidase Activity Response To Hormone Negative Regulation Of Peptidase Activity	Cell Adhesion Single Organismal Cell-cell Adhesion Protein Complex Assembly Involved In Synapse Maturation Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Gamma-aminobutyric Acid Receptor Clustering Negative Regulation Of Collagen Catabolic Process Learning Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Gephyrin Clustering Synaptic Vesicle Clustering Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Neuronal Signal Transduction N-methyl-D-aspartate Receptor Clustering Vocal Learning Negative Regulation Of Filopodium Assembly Regulation Of Blood Vessel Remodeling Postsynaptic Membrane Assembly Learning Or Memory Synapse Maturation Regulation Of Grooming Behavior Cognition Regulation Of Synaptic Transmission Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Negative Regulation Of Multicellular Organismal Metabolic Process Presynaptic Membrane Organization Auditory Behavior Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Glycoprotein Metabolic Process Extracellular Fibril Organization Cerebellar Granule Cell Differentiation Vocalization Behavior Prepulse Inhibition Neuron Cell-cell Adhesion Positive Regulation Of Synapse Maturation Single-organism Behavior Negative Regulation Of Tissue Remodeling Mechanosensory Behavior Cerebellar Granular Layer Morphogenesis Response To Auditory Stimulus Regulation Of Synapse Maturation Protein Localization To Synapse Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly
Tagcloud ?		airflow analysing antiprotease bronchial brushings categorical causal causality cd22 copd curation cystatin dataset datasets eqtl fev fvc genomics integrative manual modelling oxidant relations silico snps trait triplets upregulating xenobiotic	1e appeared basal defect deficient depleted displayed duplexes enriched exocrine explore fasting glucose gross homozygous ins intraperitoneal islet islets morphology multi pancreatic secretion sirna tolerance twofold verify viable
Tagcloud (Difference) ?		airflow analysing antiprotease bronchial brushings categorical causal causality cd22 copd curation cystatin dataset datasets eqtl fev fvc genomics integrative manual modelling oxidant relations silico snps trait triplets upregulating xenobiotic	1e appeared basal defect deficient depleted displayed duplexes enriched exocrine explore fasting glucose gross homozygous ins intraperitoneal islet islets morphology multi pancreatic secretion sirna tolerance twofold verify viable
Tagcloud (Intersection) ?