CST3 and C4A

Number of citations of the paper that reports this interaction (PMID 2304899)
5

Data Source:
HPRD (in vitro)

		CST3	C4A
Gene Name		cystatin C	complement component 4A (Rodgers blood group)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Beta-amyloid Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding	Complement Component C1q Binding Endopeptidase Inhibitor Activity
	Biological Process	Defense Response Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Regulation Of Tissue Remodeling Extracellular Fibril Organization Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Amyloids	Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Cystatin C ( 17903292)	Prostate cancer ( 23535732)
Protein-Protein Interactions		9 interactors: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115	6 interactors: APC APOA2 C3AR1 C5AR2 CR1 CST3
Entrez ID		1471	720
HPRD ID		05056	00401
Ensembl ID		ENSG00000101439	ENSG00000244731
Uniprot IDs		P01034	P0C0L4
PDB IDs		1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA	1HZF 4FXG 4FXK
Enriched GO Terms of Interacting Partners?		Cellular Response To Thyroid Hormone Stimulus Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Response To Thyroid Hormone Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Protein Catabolic Process Positive Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response Proteolysis Adaptive Immune Response Antigen Processing And Presentation Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Catabolic Process Immune System Process Immune Response-regulating Signaling Pathway Basement Membrane Disassembly Macrophage Apoptotic Process Adult Locomotory Behavior Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Hormone Stimulus Adult Behavior Myeloid Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Inflammatory Cell Apoptotic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Locomotory Behavior Regulation Of Apoptotic Cell Clearance Negative Regulation Of Endopeptidase Activity Response To Hormone Negative Regulation Of Peptidase Activity	Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Defense Response Response To Stress Negative Regulation Of Catalytic Activity Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Negative Regulation Of Cytokine Secretion Regulation Of Granulocyte Chemotaxis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Immune System Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Cholesterol Transporter Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Protein Secretion Regulation Of Cell Migration Regulation Of Leukocyte Migration Regulation Of Cell Motility Negative Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Immune Response Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Cytokine Secretion Regulation Of Chemotaxis Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Complement Activation, Alternative Pathway Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Protein Localization Negative Regulation Of Secretion By Cell Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Collagen Catabolic Process Regulation Of Cholesterol Import Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Secretion Negative Regulation Of Protein Transport Regulation Of Immune Response Regulation Of Behavior Regulation Of Protein Metabolic Process Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Extracellular Matrix Organization
Tagcloud ?		airflow analysing antiprotease bronchial brushings categorical causal causality cd22 copd curation cystatin dataset datasets eqtl fev fvc genomics integrative manual modelling oxidant relations silico snps trait triplets upregulating xenobiotic	alleles antitopoisomerase backgrounds c4aq0 c4b c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing
Tagcloud (Difference) ?		airflow analysing antiprotease bronchial brushings categorical causal causality cd22 copd curation cystatin dataset datasets eqtl fev fvc genomics integrative manual modelling oxidant relations silico snps trait triplets upregulating xenobiotic	alleles antitopoisomerase backgrounds c4aq0 c4b c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing
Tagcloud (Intersection) ?