CACYBP and S100B

Number of citations of the paper that reports this interaction (PMID 12042313)
20

Data Source:
HPRD (in vivo, in vitro)

		CACYBP	S100B
Gene Name		calcyclin binding protein	S100 calcium binding protein B
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Lumen Nucleoplasm Cytoplasm Beta-catenin Destruction Complex Neuron Projection Cell Body Extracellular Vesicular Exosome	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Homodimerization Activity	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Aging Positive Regulation Of DNA Replication Cardiac Muscle Cell Differentiation Response To Growth Hormone Negative Regulation Of Cell Death Cellular Response To Calcium Ion	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs			Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
Diseases
GWAS			Lymphocyte counts ( 22286170)
Protein-Protein Interactions		13 interactors: CD8A DYT10 MAPK1 NGFRAP1 PINX1 S100A1 S100A12 S100A6 S100B S100P SIAH1 SIAH2 SKP1	27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1
Entrez ID		27101	6285
HPRD ID		07316	01505
Ensembl ID		ENSG00000116161
Uniprot IDs		Q9HB71	P04271
PDB IDs		1X5M 2A25 2A26	1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM
Enriched GO Terms of Interacting Partners?		Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Response To Stimulus Cell Morphogenesis Neuron Differentiation Cell Projection Organization Chemotaxis Locomotion Positive Regulation Of Signal Transduction Cell Cycle Nervous System Development Movement Of Cell Or Subcellular Component Cytotoxic T Cell Differentiation Regulation Of Catalytic Activity Multicellular Organismal Development Generation Of Neurons Neurogenesis Axon Guidance Cellular Response To Stimulus Positive Regulation Of Voltage-gated Calcium Channel Activity MAPK Import Into Nucleus Apoptotic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Regulation Of Signal Transduction Cell Development Response To External Stimulus Cell Death Death Developmental Process Ubiquitin-dependent Protein Catabolic Process System Development Positive Regulation Of Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Golgi Inheritance Regulation Of Protein Stability Regulation Of Signaling Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity	Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		3months 60s brains brdu bromodeoxyuridine calcyclin candidates comparative diphosphate disabilities ds dysregulated e14 embryos eminence fingerprinting ganglionic ndpk nucleoside p0 pk postnatal proteomic pyruvate rplp0 spots tk transketolase ts1cje	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Difference) ?		3months 60s brains brdu bromodeoxyuridine calcyclin candidates comparative diphosphate disabilities ds dysregulated e14 embryos eminence fingerprinting ganglionic ndpk nucleoside p0 pk postnatal proteomic pyruvate rplp0 spots tk transketolase ts1cje	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Intersection) ?