CACYBP and PINX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CACYBP	PINX1
Description		calcyclin binding protein	PIN2 (TERF1) interacting telomerase inhibitor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Beta-catenin Destruction Complex Cell Body Extracellular Exosome	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Mitochondrion Spindle
	Molecular Function	Protein Binding Tubulin Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity S100 Protein Binding	Nucleic Acid Binding Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding
	Biological Process	Heart Development Positive Regulation Of DNA Replication Cardiac Muscle Cell Differentiation Response To Growth Hormone Cellular Response To Calcium Ion Cellular Response To Leukemia Inhibitory Factor	Telomere Maintenance Via Telomerase Mitotic Metaphase Chromosome Alignment Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Protein Localization To Nucleolus
Pathways
Drugs
Diseases
GWAS			A body shape index ( 34021172) Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder ( 30804558) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte count ( 27863252 32888494) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Retinal vascular caliber ( 21060863) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899 32154731) Triglycerides ( 30275531 24097068 20686565) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252 32888494)
Interacting Genes		22 interacting genes: BEX3 CCR2 CD8A CEBPA ERBB2 FBXO7 HSP90AA1 HSP90B1 MAPK1 NPM1 PEA15 PINX1 PRKCA S100A1 S100A12 S100A6 S100B S100P SIAH1 SIAH2 SKP1 SNCA	17 interacting genes: AIDA APP C14orf119 CACYBP EIF1AD GABPA GYS1 MCRS1 MPZ PAFAH1B2 TERF1 TERT TFRC TLK1 TNPO2 TP63 UBL5
Entrez ID		27101	54984
HPRD ID		07316	05934
Ensembl ID		ENSG00000116161	ENSG00000254093
Uniprot IDs		Q9HB71	Q96BK5
PDB IDs		1X5M 2A25 2A26
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Apoptotic Process Calcium-dependent Protein Binding Regulation Of Programmed Cell Death Regulation Of Protein Stability Protein Catabolic Process S100 Protein Binding Calcium Ion Binding Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Apoptotic Process Positive Regulation Of Defense Response Cell Death Programmed Cell Death Perinuclear Region Of Cytoplasm Proteasomal Protein Catabolic Process Positive Regulation Of Inflammatory Response Protein-containing Complex Regulation Of Protein Ubiquitination Amyloid Fibril Formation Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Programmed Cell Death Regulation Of Post-translational Protein Modification Regulation Of Immune System Process Proteolysis Involved In Protein Catabolic Process Protein Homodimerization Activity Positive Regulation Of Protein Localization To Nucleolus Tau Protein Binding Regulation Of Signal Transduction Cytosol Regulation Of Biological Quality Macromolecule Catabolic Process Positive Regulation Of Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling Sperm Plasma Membrane Long-term Synaptic Potentiation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Defense Response Intracellular Signaling Cassette Neuronal Cell Body Regulation Of Protein Localization To Nucleolus Nucleoplasm RAGE Receptor Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Nuclear Envelope Lumen Nuclear Telomere Cap Complex Telomerase Activity Regulation Of Protein Localization To Nucleolus Positive Regulation Of Protein Localization To Nucleolus Response To Manganese Ion Protein-folding Chaperone Binding Protein Homodimerization Activity Telomere Maintenance Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor Response To Leukemia Inhibitory Factor Notch Signaling Pathway RNA-templated DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Regulation Of DNA Replication Negative Regulation Of Cellular Senescence Telomeric DNA Binding Telomere Organization Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion Response To Metal Ion Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Establishment Of Protein Localization To Telomere Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Telomere Maintenance Via Telomere Lengthening TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Ectoderm And Mesoderm Interaction Epidermal Cell Division Determination Of Ventral Identity Positive Regulation Of Stem Cell Proliferation Regulation Of Cellular Senescence Acetylcholine Receptor Activator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?