GDI1 and RHOH

Number of citations of the paper that reports this interaction (PMID 11809807)
23

Data Source:
HPRD (in vitro)

		GDI1	RHOH
Gene Name		GDP dissociation inhibitor 1	ras homolog family member H
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Midbody Neuron Projection Protein Complex	Immunological Synapse Cytoplasm Cytosol Plasma Membrane
	Molecular Function	GDP-dissociation Inhibitor Activity Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Rab GTPase Binding	GTPase Inhibitor Activity Protein Binding GTP Binding Rho GTPase Binding Kinase Inhibitor Activity
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Protein Transport Rab Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Response To Calcium Ion Negative Regulation Of Protein Targeting To Membrane	Regulation Of Transcription, DNA-templated Small GTPase Mediated Signal Transduction T Cell Differentiation Negative Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mast Cell Activation Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Rho GTPase cycle Signaling by Rho GTPases	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS			Graves' disease ( 21841780)
Protein-Protein Interactions		15 interactors: CDC42 EPB41 GNL1 LNX1 PSEN1 RAB1B RAB27A RAB3B RAB6A RAB9A RABAC1 RAC2 RHOH TK1 UBQLN4	8 interactors: ARHGDIA ARHGDIB ARHGDIG GDI1 KCNH2 LRIF1 TGFBR1 UTP14A
Entrez ID		2664	399
HPRD ID		02114	03616
Ensembl ID		ENSG00000203879
Uniprot IDs		P31150	Q15669 Q6ICP4
PDB IDs
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Intracellular Signal Transduction Peptidyl-cysteine Methylation Vesicle-mediated Transport Single Organismal Cell-cell Adhesion Intracellular Transport Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Establishment Of Organelle Localization Homotypic Cell-cell Adhesion Synaptic Vesicle Transport Protein Localization Establishment Of Localization In Cell Cellular Protein Localization Regulation Of Protein Binding Organelle Localization Protein Transport Regulation Of Exocytosis Immune System Process Establishment Of Protein Localization Signal Transduction Intracellular Protein Transport T Cell Mediated Immunity Establishment Of Vesicle Localization Cellular Localization Signaling Vesicle Localization Cell Communication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Skin Morphogenesis Cell Adhesion Regulation Of Binding Synaptic Vesicle Exocytosis Organelle Transport Along Microtubule Cell Activation T Cell Aggregation T Cell Activation Antigen Processing And Presentation Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis T Cell Activation Involved In Immune Response Positive Regulation Of Constitutive Secretory Pathway Cajal-Retzius Cell Differentiation Beta-amyloid Formation Fetal Process Involved In Parturition Complement-dependent Cytotoxicity	Ras Protein Signal Transduction Rho Protein Signal Transduction Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Adhesion Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Regulation Of Protein Localization Regulation Of Intracellular Signal Transduction Negative Regulation Of Axonogenesis Positive Regulation Of Hydrolase Activity Negative Regulation Of Potassium Ion Export Regulation Of Cell Morphogenesis Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Heart Rate By Hormone Negative Regulation Of Neuron Projection Development Regulation Of Signal Transduction Regulation Of Cell Adhesion Negative Regulation Of Cell Projection Organization Regulation Of Axonogenesis Regulation Of Cellular Component Movement Negative Regulation Of Cell Differentiation Regulation Of Signaling Negative Regulation Of Neuron Differentiation Negative Regulation Of Protein Targeting To Membrane Signal Transduction Regulation Of Cell Development Positive Regulation Of Metabolic Process Parathyroid Gland Development Peptidyl-histidine Phosphorylation Regulation Of Heart Rate By Chemical Signal Signaling Regulation Of Intracellular Protein Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of Cell Projection Organization Potassium Ion Export Endothelial Cell Activation Negative Regulation Of Neurogenesis Pathway-restricted SMAD Protein Phosphorylation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Potassium Ion Transmembrane Transport
Tagcloud ?			ar autosomal broaden cutaneous deficiencies deficiency discovery epidermodysplasia ercc3 etiology ev ever1 ever2 exome fungal homozygous hpvs infections kindreds manifestations mst1 otherwise profound recessive siblings thirds tumoral unrelated verruciformis
Tagcloud (Difference) ?			ar autosomal broaden cutaneous deficiencies deficiency discovery epidermodysplasia ercc3 etiology ev ever1 ever2 exome fungal homozygous hpvs infections kindreds manifestations mst1 otherwise profound recessive siblings thirds tumoral unrelated verruciformis
Tagcloud (Intersection) ?