GDI1 and GNL1

Number of citations of the paper that reports this interaction (PubMedID 18255255)
0

Data Source:
BioGRID (two hybrid)

		GDI1	GNL1
Description		GDP dissociation inhibitor 1	G protein nucleolar 1 (putative)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Axon Midbody Protein-containing Complex Neuronal Cell Body Myelin Sheath Presynaptic Cytosol	Extracellular Space Nucleus
	Molecular Function	GDP-dissociation Inhibitor Activity Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Structural Molecule Activity GTP Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Signal Transduction Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Axon Extension Negative Regulation Of Axonogenesis Response To Calcium Ion Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Localization	T Cell Mediated Immunity DNA Damage Response Signal Transduction
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Lung cancer ( 28604730) Major depressive disorder ( 27479909) Neuroticism ( 29255261) Rosacea symptom severity ( 29771307) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		19 interacting genes: CDC42 EPB41 GNL1 LINC00632 LNX1 OGT PSEN1 RAB1B RAB27A RAB3B RAB6A RAB9A RABAC1 RAC2 RHOH RUNX1 TK1 UBQLN4 USP25	5 interacting genes: GDI1 PTP4A1 SIRPA VPS35 ZNF212
Entrez ID		2664	2794
HPRD ID		02114	00879
Ensembl ID		ENSG00000203879	ENSG00000204590
Uniprot IDs		A0A0S2Z3X8 P31150	A0A024RCR2 B4DYK6 P36915
PDB IDs
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Myosin V Binding Nucleotide Binding G Protein Activity Regulation Of Vesicle-mediated Transport Hydrolase Activity Regulation Of Proteolysis Intracellular Protein Localization Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Golgi Apparatus Regulation Of Exocytosis GDP Binding Regulation Of Synaptic Vesicle Cycle Immune System Process Endoplasmic Reticulum Membrane Protein-containing Complex Antigen Processing And Presentation Small GTPase-mediated Signal Transduction GTP-dependent Protein Binding Autophagy Cytoplasmic Vesicle Positive Regulation Of Lamellipodium Assembly Protein Localization To Golgi Apparatus Synaptic Vesicle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Myeloid Leukocyte Differentiation Positive Regulation Of Lamellipodium Organization Golgi Membrane Leukocyte Differentiation Regulation Of Lamellipodium Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Core Promoter Binding Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Peptidyl-cysteine Methylation Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Neuron Projection Organization Cortical Cytoskeleton Organization Protein Transport Regulation Of Lamellipodium Organization	Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Diamide Cellular Response To Sodium Arsenite Vesicle-mediated Transport To The Plasma Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation Of Protein Targeting To Membrane Rab GDP-dissociation Inhibitor Activity Negative Regulation Of Entry Of Bacterium Into Host Cell Neuromuscular Process General Adaptation Syndrome, Behavioral Process Positive Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Protein Homooligomerization Mitochondrion-derived Vesicle Positive Regulation Of Wnt Protein Secretion Regulation Of Locomotion Involved In Locomotory Behavior Tubular Endosome Negative Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Dopamine Metabolic Process Retromer, Cargo-selective Complex Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Voluntary Musculoskeletal Movement Regulation Of Terminal Button Organization Regulation Of Dopamine Biosynthetic Process Mitochondrion To Lysosome Vesicle-mediated Transport Negative Regulation Of Protein Oligomerization Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Protein Binding Involved In Heterotypic Cell-cell Adhesion Cellular Response To Interleukin-12 Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Response To Interleukin-12 Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Monocyte Extravasation Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Entry Of Bacterium Into Host Cell D1 Dopamine Receptor Binding Negative Regulation Of Inflammatory Response Negative Regulation Of Cellular Component Organization Negative Regulation Of Protein Localization Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Protein Antigen Binding Neurotransmitter Receptor Transport To Postsynaptic Membrane Mitochondrial Fragmentation Involved In Apoptotic Process Establishment Of Protein Localization To Postsynaptic Membrane Regulation Of Lysosomal Protein Catabolic Process Regulation Of Dopamine Receptor Signaling Pathway
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