GDI1 and RAB9A

Number of citations: 0 (PubMedID 7744738)
Data Source: HPRD (in vitro)

		GDI1	RAB9A
Name		GDP dissociation inhibitor 1	RAB9A, member RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Axon Midbody Protein-containing Complex Neuronal Cell Body Myelin Sheath Presynaptic Cytosol	Golgi Membrane Lysosome Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Melanosome Phagocytic Vesicle Extracellular Exosome
	Molecular Function	GDP-dissociation Inhibitor Activity Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Identical Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Signal Transduction Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Axon Extension Negative Regulation Of Axonogenesis Response To Calcium Ion Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Localization	Receptor-mediated Endocytosis Protein Transport Rab Protein Signal Transduction Regulation Of Protein Localization Retrograde Transport, Endosome To Golgi Positive Regulation Of Exocytosis
Pathways		RAB GEFs exchange GTP for GDP on RABs	Retrograde transport at the Trans-Golgi-Network RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs RHOBTB3 ATPase cycle
Drugs		None	Guanosine-5'-Diphosphate
Diseases		Non-syndromic X-linked mental retardation	None
GWAS		No GWAS studies recorded	Red cell distribution width ( 32888494 )
Novel Interactors		2 novel interactors: IRAK1 PACS1	None recorded
Interacting Genes		19 interacting genes: CDC42 EPB41 GNL1 LINC00632 LNX1 OGT PSEN1 RAB1B RAB27A RAB3B RAB6A RAB9A RABAC1 RAC2 RHOH RUNX1 TK1 UBQLN4 USP25	8 interacting genes: BCL3 GDI1 GDI2 PLIN3 RABEPK RHOBTB3 TM9SF2 TRIM14
Entrez ID		2664	9367
HPRD ID		02114	02236
Ensembl ID		ENSG00000203879	ENSG00000123595
Uniprot IDs		A0A0S2Z3X8 P31150	P51151
PDB IDs		Not available	1WMS 7E1T
GO Terms Enriched among Interactors		GTPase Activity GTP Binding Myosin V Binding Nucleotide Binding G Protein Activity Regulation Of Vesicle-mediated Transport Hydrolase Activity Regulation Of Proteolysis Intracellular Protein Localization Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Golgi Apparatus Regulation Of Exocytosis GDP Binding Regulation Of Synaptic Vesicle Cycle Immune System Process Endoplasmic Reticulum Membrane Protein-containing Complex Antigen Processing And Presentation Small GTPase-mediated Signal Transduction GTP-dependent Protein Binding Autophagy Cytoplasmic Vesicle Positive Regulation Of Lamellipodium Assembly Protein Localization To Golgi Apparatus Synaptic Vesicle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Myeloid Leukocyte Differentiation Positive Regulation Of Lamellipodium Organization Golgi Membrane Leukocyte Differentiation Regulation Of Lamellipodium Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Core Promoter Binding Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Peptidyl-cysteine Methylation Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Neuron Projection Organization Cortical Cytoskeleton Organization Protein Transport Regulation Of Lamellipodium Organization	Rab GDP-dissociation Inhibitor Activity GDP-dissociation Inhibitor Activity Vesicle-mediated Transport Golgi Apparatus Small GTPase Binding Endosome Membrane Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Cytoplasm Follicular Dendritic Cell Differentiation Transport Vesicle Trans-Golgi Network Membrane Follicular Dendritic Cell Activation Negative Regulation Of Protein Localization To Cilium Positive Regulation Of Triglyceride Storage Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process