GDI1 and RAB1B

Number of citations of the paper that reports this interaction (PubMedID 8836150)
61

Data Source:
HPRD (in vivo)

		GDI1	RAB1B
Description		GDP dissociation inhibitor 1	RAB1B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Axon Midbody Protein-containing Complex Neuronal Cell Body Myelin Sheath Presynaptic Cytosol	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Phagophore Assembly Site Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	GDP-dissociation Inhibitor Activity Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Signal Transduction Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Axon Extension Negative Regulation Of Axonogenesis Response To Calcium Ion Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Localization	Autophagosome Assembly Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Autophagy Golgi Organization Protein Transport Virion Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Autophagosome Assembly
Pathways		RAB GEFs exchange GTP for GDP on RABs	Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS			Bipolar disorder ( 21926972 31043756)
Interacting Genes		19 interacting genes: CDC42 EPB41 GNL1 LINC00632 LNX1 OGT PSEN1 RAB1B RAB27A RAB3B RAB6A RAB9A RABAC1 RAC2 RHOH RUNX1 TK1 UBQLN4 USP25	12 interacting genes: APP CHM FNDC3B GDI1 GOLGA2 LINC00632 MICAL1 MICAL3 RABIF RUSC2 SMARCC2 TOMM40L
Entrez ID		2664	81876
HPRD ID		02114	11469
Ensembl ID		ENSG00000203879	ENSG00000174903
Uniprot IDs		A0A0S2Z3X8 P31150	Q9H0U4
PDB IDs			3JZA 3NKV 4HLQ 4I1O 5O74 5SZH 5SZK 6SKU 8ALK
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Myosin V Binding Nucleotide Binding G Protein Activity Regulation Of Vesicle-mediated Transport Hydrolase Activity Regulation Of Proteolysis Intracellular Protein Localization Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Golgi Apparatus Regulation Of Exocytosis GDP Binding Regulation Of Synaptic Vesicle Cycle Immune System Process Endoplasmic Reticulum Membrane Protein-containing Complex Antigen Processing And Presentation Small GTPase-mediated Signal Transduction GTP-dependent Protein Binding Autophagy Cytoplasmic Vesicle Positive Regulation Of Lamellipodium Assembly Protein Localization To Golgi Apparatus Synaptic Vesicle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Myeloid Leukocyte Differentiation Positive Regulation Of Lamellipodium Organization Golgi Membrane Leukocyte Differentiation Regulation Of Lamellipodium Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Core Promoter Binding Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Peptidyl-cysteine Methylation Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Neuron Projection Organization Cortical Cytoskeleton Organization Protein Transport Regulation Of Lamellipodium Organization	F-actin Monooxygenase Activity Small GTPase Binding Actin Filament Depolymerization Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen GDP-dissociation Inhibitor Activity Vesicle-mediated Transport Protein-containing Complex Disassembly Regulation Of Toll-like Receptor Signaling Pathway Midbody FAD Binding Protein Depolymerization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Transport Small GTPase-mediated Signal Transduction Actin Polymerization Or Depolymerization Golgi Vesicle Transport Monooxygenase Activity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Protein Localization Rab GDP-dissociation Inhibitor Activity Sulfur Oxidation Hippocampal Mossy Fiber Expansion Protein-containing Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Intercellular Bridge Intracellular Signaling Cassette Post-Golgi Vesicle-mediated Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity
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