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GDF9 and S100A8
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
GDF9
S100A8
Description
growth differentiation factor 9
S100 calcium binding protein A8
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Membrane
Extracellular Matrix
Secretory Granule Lumen
Intermediate Filament Cytoskeleton
Extracellular Exosome
Calprotectin Complex
S100A8 Complex
Molecular Function
Cytokine Activity
Growth Factor Activity
Calcium Ion Binding
Protein Binding
Microtubule Binding
Zinc Ion Binding
Toll-like Receptor 4 Binding
Metal Ion Binding
Calcium-dependent Protein Binding
Arachidonate Binding
RAGE Receptor Binding
Biological Process
Oocyte Growth
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Female Gamete Generation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Growth
Regulation Of Progesterone Secretion
Immune System Process
Leukocyte Migration Involved In Inflammatory Response
Chronic Inflammatory Response
Peptide Secretion
Positive Regulation Of Peptide Secretion
Autophagy
Apoptotic Process
Chemotaxis
Inflammatory Response
Response To Zinc Ion
Astrocyte Development
Peptidyl-cysteine S-nitrosylation
Positive Regulation Of Cell Growth
Neutrophil Chemotaxis
Response To Lipopolysaccharide
Regulation Of Toll-like Receptor Signaling Pathway
Autocrine Signaling
Defense Response To Bacterium
Endothelial Cell Migration
Innate Immune Response
Response To Ethanol
Positive Regulation Of Inflammatory Response
Defense Response To Fungus
Regulation Of Cytoskeleton Organization
Neutrophil Aggregation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
RHO GTPases Activate NADPH Oxidases
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Metal sequestration by antimicrobial proteins
Drugs
Calcium
Zinc
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Asthma (
31619474
)
Asthma (
31619474
)
Matrix metalloproteinase-8 levels (
29212897
)
Monocyte count (
32888494
)
Interacting Genes
45 interacting genes:
ACVR2A
ADPGK
ANXA7
APLP1
BMP15
BMPR1A
BMPR1B
BMPR2
BTBD2
CDKN1A
CDKN2C
CRELD1
CRIPTO
DLEU1
DNM2
FOXG1
FXYD6
GADD45G
ILF3
KDM1A
KIF22
LSM3
MOB4
MPHOSPH6
MYCBP
NDUFB9
ORAI2
PABPC4
PAFAH1B3
PCDHA4
PCYT2
PMF1
PRKRA
PSMD11
RAB27A
RSRC1
S100A8
SAT1
SERPINB9
SMN1
SNRPG
STRN4
TK1
TRIB3
WASHC3
22 interacting genes:
APP
CDKN1A
CEACAM3
CHGB
ERG28
GDF9
IGSF21
KLC2
LRIF1
NCF2
PCNA
PDCD11
PPIA
PRMT1
PTEN
RAB17
S100A9
TP53
TUBA1A
TUBA4A
TUBB
UNC119
Entrez ID
2661
6279
HPRD ID
03560
00471
Ensembl ID
ENSG00000164404
ENSG00000143546
Uniprot IDs
B4DXG3
O60383
P05109
PDB IDs
1MR8
1XK4
4GGF
4XJK
5HLO
5HLV
5W1F
6DS2
7QUV
8SJB
8SJC
Enriched GO Terms of Interacting Partners
?
BMP Receptor Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Cellular Response To BMP Stimulus
Positive Regulation Of Bone Mineralization
Positive Regulation Of Biomineral Tissue Development
Positive Regulation Of Ossification
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Activin Receptor Activity, Type II
BMP Binding
Positive Regulation Of Osteoblast Differentiation
Tricuspid Valve Morphogenesis
Activin Receptor Signaling Pathway
Regulation Of Bone Mineralization
BMP Signaling Pathway
Transforming Growth Factor Beta Receptor Activity, Type I
Negative Regulation Of Chondrocyte Proliferation
Regionalization
Endochondral Bone Morphogenesis
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Developmental Process
Positive Regulation Of SMAD Protein Signal Transduction
HFE-transferrin Receptor Complex
Mitral Valve Morphogenesis
RNA Splicing, Via Transesterification Reactions
Regulation Of Ossification
Pharyngeal Arch Artery Morphogenesis
Osteoblast Differentiation
Mesenchyme Development
Endocardial Cushion Development
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Positive Regulation Of Programmed Cell Death
Pattern Specification Process
Regulation Of Osteoblast Differentiation
Dorsal/ventral Pattern Formation
Cellular Response To Growth Factor Stimulus
Regulation Of SMAD Protein Signal Transduction
Cellular Developmental Process
Cell Differentiation
SMN-Sm Protein Complex
FAR/SIN/STRIPAK Complex
Anterior/posterior Pattern Specification
Kinase Activity
Precatalytic Spliceosome
Atrioventricular Valve Morphogenesis
Epithelial Cell Proliferation
Protein Binding
Response To Light Stimulus
Molecular Function Activator Activity
PCNA-p21 Complex
Enzyme Binding
Response To Radiation
Regulation Of Phosphorus Metabolic Process
Regulation Of Growth
RAGE Receptor Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway
Microtubule-based Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Nuclear Envelope Lumen
Heparan Sulfate Binding
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Phosphate Metabolic Process
Stress-induced Premature Senescence
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Forebrain Morphogenesis
Cytoskeleton-dependent Intracellular Transport
Mitotic G1 DNA Damage Checkpoint Signaling
Negative Regulation Of Growth
Regulation Of DNA Biosynthetic Process
Replicative Senescence
Synapse Maturation
Cellular Response To UV
Mitotic G1/S Transition Checkpoint Signaling
Response To L-glutamate
Structural Constituent Of Cytoskeleton
Synapse Organization
Protein-containing Complex
Protein Serine/threonine Kinase Binding
Negative Regulation Of Protein Phosphorylation
Heart Development
Cellular Response To Light Stimulus
Circadian Behavior
Rhythmic Behavior
Response To Amino Acid
Regulation Of DNA Replication
Negative Regulation Of Phosphorylation
Positive Regulation Of Protein Metabolic Process
Dentate Gyrus Development
Regulation Of Cellular Component Organization
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Synapse Organization
Positive Regulation Of Excitatory Postsynaptic Potential
Recycling Endosome
Regulation Of Reactive Oxygen Species Metabolic Process
Cytosol
Regulation Of Cellular Response To Stress
Negative Regulation Of DNA Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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