GDF9 and ORAI2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GDF9	ORAI2
Gene Name		growth differentiation factor 9	ORAI calcium release-activated calcium modulator 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm	Integral Component Of Membrane Growth Cone
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity	Protein Binding
	Biological Process	Oocyte Growth Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth BMP Signaling Pathway Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cell Development SMAD Protein Signal Transduction Regulation Of Progesterone Secretion
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CCDC53 CDKN1A CDKN2C CRELD1 DLEU1 DNM2 FOXG1 FXYD6 GADD45G ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TDGF1 TK1 TRIB3	5 interactors: COPS6 GDF9 MED31 SETDB1 UNC119
Entrez ID		2661	80228
HPRD ID		03560	09860
Ensembl ID		ENSG00000164404	ENSG00000160991
Uniprot IDs		B4DXG3 O60383	B4DUB4 Q96SN7
PDB IDs
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Chondrocyte Proliferation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Developmental Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process System Development Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Ossification Nitrogen Compound Metabolic Process Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Signal Transduction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Immune System Process Regulation Of Cell Death RNA Metabolic Process RNA Processing Phosphate-containing Compound Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Osteoblast Differentiation Gene Expression Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Gene Expression Regulation Of Phosphorylation Regulation Of Cell Growth Organ Development Gastrulation Positive Regulation Of Metabolic Process	Negative Regulation Of Clathrin-mediated Endocytosis Oocyte Growth Negative Regulation Of Caveolin-mediated Endocytosis Cytokinesis, Completion Of Separation Regulation Of Progesterone Secretion Regulation Of Caveolin-mediated Endocytosis Developmental Growth Mitotic Cytokinetic Process Cullin Deneddylation Histone H3-K9 Trimethylation Protein Deneddylation Regulation Of Clathrin-mediated Endocytosis Regulation Of Female Gonad Development Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Growth Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Methylation Inner Cell Mass Cell Proliferation Peptidyl-lysine Trimethylation Blastocyst Growth
Tagcloud ?		3h bmp bmp15 bmpr2 decapentaplegic differing granulosa incorporation involves jnk jun kb mapk morphogenetic mothers ovine p3h pathways signalling sma smad smad1 smad2 steroid stimulate synergistic synergistically thymidine utilised	200nm ae aminoethoxydiphenyl apb blocker blocks borinate ca2 coupling dimeric dpb162 f394h generates infer narrowed orai1 orai3 potently pumps restores slowly soar stim stim1 stim2 store trpc uncoupler
Tagcloud (Difference) ?		3h bmp bmp15 bmpr2 decapentaplegic differing granulosa incorporation involves jnk jun kb mapk morphogenetic mothers ovine p3h pathways signalling sma smad smad1 smad2 steroid stimulate synergistic synergistically thymidine utilised	200nm ae aminoethoxydiphenyl apb blocker blocks borinate ca2 coupling dimeric dpb162 f394h generates infer narrowed orai1 orai3 potently pumps restores slowly soar stim stim1 stim2 store trpc uncoupler
Tagcloud (Intersection) ?