GCDH and RNF32

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		GCDH	RNF32
Description		glutaryl-CoA dehydrogenase	ring finger protein 32
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Endosome Cytosol Aggresome Nuclear Body
	Molecular Function	Fatty-acyl-CoA Binding Acyl-CoA Dehydrogenase Activity Glutaryl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	L-tryptophan Metabolic Process Acyl-CoA Metabolic Process Fatty Acid Oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Fatty-acyl-CoA Biosynthetic Process
Pathways		Lysine catabolism
Drugs		Flavin adenine dinucleotide S-4-Nitrobutyryl-CoA
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS		Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 19862010 27863252) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum metabolite levels ( 33031748)	Glomerular filtration rate (creatinine) ( 26831199)
Interacting Genes		10 interacting genes: A2M APOE CDC37 ECSIT EXOC6 MAST1 NOS3 PSEN1 PSEN2 RNF32	42 interacting genes: A2M APOE APP BLMH CDC37 CDK5 CEP55 CYP2C8 CYP2C9 ECSIT ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 FIBP GCDH HOXC4 IFIT3 IFIT5 LONP1 LOXL4 LZTS2 MAST1 MKRN3 MNAT1 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN1 PSEN2 RAB3A RAB3D RAD23A RPP30 STAMBPL1 TRIM23 TRIM74 UBE2K
Entrez ID		2639	140545
HPRD ID		01977	11517
Ensembl ID		ENSG00000105607	ENSG00000105982
Uniprot IDs		Q92947	G5E940 Q9H0A6
PDB IDs		1SIQ 1SIR 2R0M 2R0N
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Amyloid-beta Formation Notch Receptor Processing Regulation Of Amyloid Fibril Formation Negative Regulation Of Platelet Activation Amyloid Precursor Protein Catabolic Process Nitric Oxide Mediated Signal Transduction Intracellular Signal Transduction Growth Cone Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Regulation Of Immune Response Regulation Of Innate Immune Response Magnesium Ion Binding Dendrite Negative Regulation Of Phospholipid Efflux Negative Regulation Of Coagulation Vasodilation Negative Regulation Of Blood Coagulation Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Positive Regulation Of Dendritic Spine Development Cellular Response To Amyloid-beta Calcium Ion Homeostasis Regulation Of Dendritic Spine Development Regulation Of Platelet Activation Negative Regulation Of Hemostasis Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Membrane Fission Aggresome Negative Regulation Of Core Promoter Binding Membrane Protein Proteolysis Thiamine Triphosphate Phosphatase Activity Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Complement Activation, Lectin Pathway Alcohol Metabolic Process Positive Regulation Of Presynaptic Membrane Organization Negative Regulation Of Wound Healing Response To Amyloid-beta Chylomicron Remnant Maintenance Of Location In Cell Regulation Of Blood Coagulation Lipid Transport Involved In Lipid Storage Lipoprotein Particle	Positive Regulation Of Amyloid Fibril Formation Lipoprotein Particle Catabolic Process Acetylcholine Receptor Activator Activity Cellular Response To Amyloid-beta Regulation Of Amyloid Fibril Formation Response To Amyloid-beta Amyloid Precursor Protein Metabolic Process Astrocyte Activation Involved In Immune Response Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Gamma-secretase Complex Regulation Of Synaptic Plasticity Macromolecule Catabolic Process Oxidative Demethylation Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Amyloid-beta Formation Notch Receptor Processing Regulation Of Proteolysis Regulation Of Vesicle-mediated Transport Demethylation Synaptic Vesicle Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Negative Regulation Of Long-term Synaptic Potentiation Growth Cone Regulation Of Immune Response Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Epoxygenase P450 Pathway Synaptic Membrane Mitotic Cytokinesis Low-density Lipoprotein Particle Removal Of Superoxide Radicals Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Regulation Of Innate Immune Response Regulation Of Hemostasis Amyloid Precursor Protein Catabolic Process Maintenance Of Location In Cell Heparan Sulfate Proteoglycan Binding Negative Regulation Of Platelet Activation Astrocyte Activation
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