GCDH and CDC37

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		GCDH	CDC37
Gene Name		glutaryl-CoA dehydrogenase	cell division cycle 37
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Cytoplasm Cytosol Ruffle Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Fatty-acyl-CoA Binding Glutaryl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding	Protein Binding Kinase Binding Heat Shock Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Kinase B Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Lysine Catabolic Process Tryptophan Metabolic Process Fatty Acid Oxidation Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Fatty-acyl-CoA Biosynthetic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Lysine catabolism Metabolism of amino acids and derivatives	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Constitutive Signaling by EGFRvIII
Drugs		Flavin-Adenine Dinucleotide S-4-Nitrobutyryl-Coa
Diseases
GWAS		Mean corpuscular hemoglobin ( 19862010)	Multiple sclerosis ( 21833088)
Protein-Protein Interactions		10 interactors: A2M APOE CDC37 ECSIT EXOC6 MAST1 NOS3 PSEN1 PSEN2 RNF32	72 interactors: A2M APOE APP AR BTBD10 C19orf44 CC2D1A CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CYP2C9 DCTN1 DEAF1 ECSIT EIF2AK1 ELAVL3 EXOSC1 FBXL12 FBXW4 GCDH GCH1 HSP90AA1 IFIT3 IFIT5 IKBKB IKBKE IKBKG IMMT LONP1 LOXL4 LUC7L2 MAP3K14 MAP3K3 MGEA5 MTOR MZT2B NCOA5 NOS3 NR2C2 PPHLN1 PRAM1 PRDX2 PRMT1 PSME1 RAD23A RNF32 RPS15A SAFB SNX5 SPTBN4 SQSTM1 SRC STAMBPL1 STIP1 STK11 TBK1 UBE2I ZNF205 ZNF235 ZNF266 ZNF667
Entrez ID		2639	11140
HPRD ID		01977	05456
Ensembl ID		ENSG00000105607	ENSG00000105401
Uniprot IDs		Q92947	Q16543
PDB IDs		1SIQ 1SIR 2R0M 2R0N	1US7 2K5B 2W0G
Enriched GO Terms of Interacting Partners?		Regulation Of Oxidoreductase Activity Regulation Of Catalytic Activity Amyloid Precursor Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Intracellular Signal Transduction Nitric Oxide Mediated Signal Transduction Negative Regulation Of Platelet Activation Positive Regulation Of CGMP Biosynthetic Process Protein Localization Regulation Of Cellular Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Positive Regulation Of CGMP Metabolic Process Establishment Of Localization In Cell Regulation Of Synaptic Plasticity Regulation Of CGMP Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Metabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Dorsal/ventral Neural Tube Patterning Regulation Of Platelet Activation Developmental Process Regulation Of CGMP Metabolic Process Cellular Localization Positive Regulation Of Coagulation Anatomical Structure Morphogenesis Protein Transport Membrane Protein Proteolysis Myeloid Cell Differentiation Brain Morphogenesis Negative Regulation Of Apoptotic Signaling Pathway Establishment Of Protein Localization Regulation Of Nitric-oxide Synthase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Cellular Calcium Ion Homeostasis Regulation Of Signal Transduction Calcium Ion Homeostasis Regulation Of Synaptic Transmission Blood Circulation Thymus Development Negative Regulation Of Protein Phosphorylation	Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Cellular Metabolic Process Response To External Stimulus Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Kinase Activity I-kappaB Kinase/NF-kappaB Signaling Response To Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mitotic Cell Cycle Phase Transition Response To Virus Cell Cycle Phase Transition Catabolic Process Regulation Of Catalytic Activity Intracellular Receptor Signaling Pathway Cell Cycle Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cell Cycle Process Regulation Of Signal Transduction Protein Catabolic Process Mitotic Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Signaling Toll-like Receptor 3 Signaling Pathway Regulation Of Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus
Tagcloud ?		1031c 1109t 148t 628a 700c 731g 963g aciduria acidurias athetosis checked cranial drowsiness dystonia fissure ganglia glutaric got infant intelligence leukoencephalopathy pediatrics peking psychomotor retardation sylvian vomiting w50r widening	base chick clusters conforms consensus copies emphasize exons finger flanking gctat ggg glycosaminoglycans homeodomain hsp90 introns kilobases mzf1 pair presumptive promotion reorganization repetitive s8 sizes sp1 stabilization striking tatgggga
Tagcloud (Difference) ?		1031c 1109t 148t 628a 700c 731g 963g aciduria acidurias athetosis checked cranial drowsiness dystonia fissure ganglia glutaric got infant intelligence leukoencephalopathy pediatrics peking psychomotor retardation sylvian vomiting w50r widening	base chick clusters conforms consensus copies emphasize exons finger flanking gctat ggg glycosaminoglycans homeodomain hsp90 introns kilobases mzf1 pair presumptive promotion reorganization repetitive s8 sizes sp1 stabilization striking tatgggga
Tagcloud (Intersection) ?