GCDH and MAST1

Number of citations: 58 (PubMedID 21163940)
Data Source: BioGRID (two hybrid)

		GCDH	MAST1
Name		glutaryl-CoA dehydrogenase	microtubule associated serine/threonine kinase 1
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	Fatty-acyl-CoA Binding Acyl-CoA Dehydrogenase Activity Glutaryl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	L-tryptophan Metabolic Process Acyl-CoA Metabolic Process Fatty Acid Oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Fatty-acyl-CoA Biosynthetic Process	Protein Phosphorylation Cytoskeleton Organization Brain Development Developmental Process Intracellular Signal Transduction
Pathways		Lysine catabolism	None
Drugs		Flavin adenine dinucleotide S-4-Nitrobutyryl-CoA	Fostamatinib
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	None
GWAS		Clozapine-induced agranulocytosis ( 25187353 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 19862010 27863252 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Serum metabolite levels ( 33031748 )	High light scatter reticulocyte count ( 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Intelligence (MTAG) ( 29326435 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Red blood cell count ( 29403010 ) Reticulocyte fraction of red cells ( 32888494 )
Interacting Genes		10 interacting genes: A2M APOE CDC37 ECSIT EXOC6 MAST1 NOS3 PSEN1 PSEN2 RNF32	41 interacting genes: A2M ACE2 AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH IFIT3 IFIT5 LONP1 LOXL4 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 RPS6KA1 SNTA1 SNTB2 STAMBPL1 TIAM1 VANGL2
Entrez ID		2639	22983
HPRD ID		01977	17469
Ensembl ID		ENSG00000105607	ENSG00000105613
Uniprot IDs		Q92947	Q9Y2H9
PDB IDs		1SIQ 1SIR 2R0M 2R0N	2M9X 3PS4
GO Terms Enriched among Interactors		Amyloid Precursor Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Amyloid-beta Formation Notch Receptor Processing Regulation Of Amyloid Fibril Formation Negative Regulation Of Platelet Activation Amyloid Precursor Protein Catabolic Process Nitric Oxide Mediated Signal Transduction Intracellular Signal Transduction Growth Cone Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Regulation Of Immune Response Regulation Of Innate Immune Response Magnesium Ion Binding Dendrite Negative Regulation Of Phospholipid Efflux Negative Regulation Of Coagulation Vasodilation Negative Regulation Of Blood Coagulation Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Positive Regulation Of Dendritic Spine Development Cellular Response To Amyloid-beta Calcium Ion Homeostasis Regulation Of Dendritic Spine Development Regulation Of Platelet Activation Negative Regulation Of Hemostasis Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Membrane Fission Aggresome Negative Regulation Of Core Promoter Binding Membrane Protein Proteolysis Thiamine Triphosphate Phosphatase Activity Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Complement Activation, Lectin Pathway Alcohol Metabolic Process Positive Regulation Of Presynaptic Membrane Organization Negative Regulation Of Wound Healing Response To Amyloid-beta Chylomicron Remnant Maintenance Of Location In Cell Regulation Of Blood Coagulation Lipid Transport Involved In Lipid Storage Lipoprotein Particle	Lipoprotein Particle Acetylcholine Receptor Activator Activity Negative Regulation Of Smooth Muscle Cell Proliferation Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Positive Regulation Of Amyloid Fibril Formation Chemical Synaptic Transmission Catabolic Process Cytosol Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Trans-synaptic Signaling Oxidative Demethylation Synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Oxidoreductase Activity Arachidonate Epoxygenase Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Wound Healing Negative Regulation Of Long-term Synaptic Potentiation Regulation Of System Process Regulation Of Blood Circulation Demethylation Regulation Of Dendritic Spine Maintenance Response To Amyloid-beta Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Axonogenesis Epoxygenase P450 Pathway Low-density Lipoprotein Particle Removal Of Superoxide Radicals Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Dystrophin-associated Glycoprotein Complex Regulation Of Hemostasis Heparan Sulfate Proteoglycan Binding Intracellular Signaling Cassette Regulation Of Amyloid Fibril Formation Regulation Of Response To Wounding Negative Regulation Of Platelet Activation Cognition Cellular Oxidant Detoxification Regulation Of Transport Ubiquitin-specific Protease Binding Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance