GCDH and EXOC6

Number of citations: 58 (PubMedID 21163940)
Data Source: BioGRID (two hybrid)

		GCDH	EXOC6
Name		glutaryl-CoA dehydrogenase	exocyst complex component 6
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Exocyst Cytoplasm Cytosol Plasma Membrane Growth Cone Cell Projection Perinuclear Region Of Cytoplasm Flemming Body
	Molecular Function	Fatty-acyl-CoA Binding Acyl-CoA Dehydrogenase Activity Glutaryl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding	Protein Binding
	Biological Process	L-tryptophan Metabolic Process Acyl-CoA Metabolic Process Fatty Acid Oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Fatty-acyl-CoA Biosynthetic Process	Mitotic Cytokinesis Intracellular Protein Transport Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways		Lysine catabolism	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs		Flavin adenine dinucleotide S-4-Nitrobutyryl-CoA	None
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	None
GWAS		Clozapine-induced agranulocytosis ( 25187353 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 19862010 27863252 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Serum metabolite levels ( 33031748 )	Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325 ) Age-related hearing impairment ( 34108613 ) Body mass index ( 28892062 ) Coronary artery disease ( 29212778 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Eosinophil percentage of white cells ( 32888494 ) Estimated glomerular filtration rate ( 31015462 ) Glaucoma (primary open-angle) ( 29449654 ) Hemoglobin A1c levels ( 29403010 ) High density lipoprotein cholesterol levels ( 29403010 33339817 ) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273 ) Intraocular pressure ( 30054594 ) Metabolic syndrome ( 31589552 ) Platelet distribution width ( 32888494 ) Refractive error ( 32231278 ) Total bilirubin levels ( 29403010 )
Interacting Genes		10 interacting genes: A2M APOE CDC37 ECSIT EXOC6 MAST1 NOS3 PSEN1 PSEN2 RNF32	11 interacting genes: APP CYP2C8 ECSIT EXOSC1 GCDH LOXL4 MAST1 NOS3 PRDX2 PSEN2 RNF32
Entrez ID		2639	54536
HPRD ID		01977	10216
Ensembl ID		ENSG00000105607	ENSG00000138190
Uniprot IDs		Q92947	A5YP36 B2RDH5 B3KXY5 B7Z6G5 E7EW84 Q8TAG9
PDB IDs		1SIQ 1SIR 2R0M 2R0N	Not available
GO Terms Enriched among Interactors		Amyloid Precursor Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Amyloid-beta Formation Notch Receptor Processing Regulation Of Amyloid Fibril Formation Negative Regulation Of Platelet Activation Amyloid Precursor Protein Catabolic Process Nitric Oxide Mediated Signal Transduction Intracellular Signal Transduction Growth Cone Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Regulation Of Immune Response Regulation Of Innate Immune Response Magnesium Ion Binding Dendrite Negative Regulation Of Phospholipid Efflux Negative Regulation Of Coagulation Vasodilation Negative Regulation Of Blood Coagulation Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Positive Regulation Of Dendritic Spine Development Cellular Response To Amyloid-beta Calcium Ion Homeostasis Regulation Of Dendritic Spine Development Regulation Of Platelet Activation Negative Regulation Of Hemostasis Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Membrane Fission Aggresome Negative Regulation Of Core Promoter Binding Membrane Protein Proteolysis Thiamine Triphosphate Phosphatase Activity Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Complement Activation, Lectin Pathway Alcohol Metabolic Process Positive Regulation Of Presynaptic Membrane Organization Negative Regulation Of Wound Healing Response To Amyloid-beta Chylomicron Remnant Maintenance Of Location In Cell Regulation Of Blood Coagulation Lipid Transport Involved In Lipid Storage Lipoprotein Particle	Oxidoreductase Activity Removal Of Superoxide Radicals Regulation Of Extrinsic Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium Ion Transport Regulation Of Metal Ion Transport Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Glutaryl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding Nitric-oxide Synthase Activity Cell Redox Homeostasis Smooth Muscle Hyperplasia Superoxide Metabolic Process Tetrahydrobiopterin Binding Cellular Oxidant Detoxification Negative Regulation Of Muscle Hyperplasia Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation Respiratory Burst Involved In Inflammatory Response Regulation Of Spontaneous Synaptic Transmission Regulation Of Calcium Ion Transmembrane Transport Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Monoatomic Ion Transport Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Positive Regulation Of Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process