GCDH and EXOC6

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		GCDH	EXOC6
Gene Name		glutaryl-CoA dehydrogenase	exocyst complex component 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Exocyst Cytosol Plasma Membrane
	Molecular Function	Fatty-acyl-CoA Binding Glutaryl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Lysine Catabolic Process Tryptophan Metabolic Process Fatty Acid Oxidation Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Fatty-acyl-CoA Biosynthetic Process	Vesicle Docking Involved In Exocytosis Organelle Organization Protein Transport Erythrocyte Differentiation Cellular Protein Metabolic Process Membrane Organization
Pathways		Lysine catabolism Metabolism of amino acids and derivatives	Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing
Drugs		Flavin-Adenine Dinucleotide S-4-Nitrobutyryl-Coa
Diseases
GWAS		Mean corpuscular hemoglobin ( 19862010)
Protein-Protein Interactions		10 interactors: A2M APOE CDC37 ECSIT EXOC6 MAST1 NOS3 PSEN1 PSEN2 RNF32	11 interactors: APP CYP2C8 ECSIT EXOSC1 GCDH LOXL4 MAST1 NOS3 PRDX2 PSEN2 RNF32
Entrez ID		2639	54536
HPRD ID		01977	10216
Ensembl ID		ENSG00000105607	ENSG00000138190
Uniprot IDs		Q92947	B3KXY5 E7EW84 F2Z2Q3 Q8TAG9
PDB IDs		1SIQ 1SIR 2R0M 2R0N
Enriched GO Terms of Interacting Partners?		Regulation Of Oxidoreductase Activity Regulation Of Catalytic Activity Amyloid Precursor Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Intracellular Signal Transduction Nitric Oxide Mediated Signal Transduction Negative Regulation Of Platelet Activation Positive Regulation Of CGMP Biosynthetic Process Protein Localization Regulation Of Cellular Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Positive Regulation Of CGMP Metabolic Process Establishment Of Localization In Cell Regulation Of Synaptic Plasticity Regulation Of CGMP Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Metabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Dorsal/ventral Neural Tube Patterning Regulation Of Platelet Activation Developmental Process Regulation Of CGMP Metabolic Process Cellular Localization Positive Regulation Of Coagulation Anatomical Structure Morphogenesis Protein Transport Membrane Protein Proteolysis Myeloid Cell Differentiation Brain Morphogenesis Negative Regulation Of Apoptotic Signaling Pathway Establishment Of Protein Localization Regulation Of Nitric-oxide Synthase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Cellular Calcium Ion Homeostasis Regulation Of Signal Transduction Calcium Ion Homeostasis Regulation Of Synaptic Transmission Blood Circulation Thymus Development Negative Regulation Of Protein Phosphorylation	Oxidation-reduction Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Epidermal Growth Factor-activated Receptor Activity Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Catabolic Process Regulation Of Oxidoreductase Activity Axon Guidance Regulation Of ERBB Signaling Pathway Smooth Muscle Hyperplasia Synaptic Growth At Neuromuscular Junction Reactive Oxygen Species Metabolic Process Regulation Of Receptor Activity Cellular Amino Acid Catabolic Process Axonogenesis Locomotion Collateral Sprouting In Absence Of Injury Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Notch Signaling Pathway Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Binding Smooth Muscle Adaptation Chemotaxis Anatomical Structure Morphogenesis Negative Regulation Of Muscle Hyperplasia Collateral Sprouting Regulation Of Systemic Arterial Blood Pressure By Endothelin Axon Midline Choice Point Recognition Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cell Morphogenesis Involved In Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Carboxylic Acid Catabolic Process Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Peptidyl-tyrosine Phosphorylation Lysine Catabolic Process Arginine Catabolic Process Omega-hydroxylase P450 Pathway Negative Regulation Of Cellular Protein Metabolic Process Neuron Remodeling Neuron Projection Development Exit From Mitosis Metabolic Process Cell Projection Morphogenesis Lung Development
Tagcloud ?		1031c 1109t 148t 628a 700c 731g 963g aciduria acidurias athetosis checked cranial drowsiness dystonia fissure ganglia glutaric got infant intelligence leukoencephalopathy pediatrics peking psychomotor retardation sylvian vomiting w50r widening
Tagcloud (Difference) ?		1031c 1109t 148t 628a 700c 731g 963g aciduria acidurias athetosis checked cranial drowsiness dystonia fissure ganglia glutaric got infant intelligence leukoencephalopathy pediatrics peking psychomotor retardation sylvian vomiting w50r widening
Tagcloud (Intersection) ?