HSPB8 and CATSPERT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSPB8	CATSPERT
Description		heat shock protein family B (small) member 8	catsper channel auxiliary subunit tau
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Folding Chaperone Complex	Plasma Membrane Cilium Membrane Motile Cilium CatSper Complex Cell Projection Sperm Principal Piece
	Molecular Function	Protein Kinase Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Cellular Response To Unfolded Protein Positive Regulation Of Aggrephagy	Spermatogenesis Flagellated Sperm Motility Sperm Capacitation Vesicle-mediated Transport To The Plasma Membrane
Pathways		HSF1-dependent transactivation
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS		Metabolite levels ( 23823483) PR interval in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes		21 interacting genes: ATOSB ATXN7L2 BAG3 CATSPERT CRYAB CSNK2A1 DUSP12 HSPB1 HSPB2 HSPB3 HSPB6 HSPB7 MAPK3 MISP PRKCA QRICH1 RPIA SLC16A5 SNCA SOCS7 TRAPPC6A	62 interacting genes: ACOT11 ACTN3 ANKK1 AP2B1 BBS4 BRCA1 CARD9 CCDC172 CCDC57 CCDC85B CDR2 CHCHD3 CNOT11 CT55 DISC1 DNAJA3 FAM217B FHL2 GOLGA2 GPRASP3 GRAMD4 HAP1 HSF2BP HSPB8 IKZF3 JRK KIFC3 KRT13 KRT15 KRT31 KRT40 KRT75 LHX1 LHX3 LZTS2 MCM6 MCRS1 MEAF6 MEOX1 MIPOL1 MTUS2 NR5A1 NUTM1 PAX6 PIBF1 RNF8 SPATA2 TACC3 TCP10L TEX11 TFIP11 TLE5 TRAF1 TRAF2 TRIM23 TRIM54 TSSK3 VAC14 VIM VPS52 ZNF474 ZNRD2
Entrez ID		26353	151254
HPRD ID		06420	08687
Ensembl ID		ENSG00000152137	ENSG00000155754
Uniprot IDs		Q9UJY1	A0A140VJE2 Q53TS8
PDB IDs		8S7A
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Protein Refolding Response To Heat Protein Folding Response To Temperature Stimulus Structural Constituent Of Eye Lens Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Unfolded Protein Binding Positive Regulation Of Aggrephagy Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Stability Regulation Of Autophagy Response To Stress Contractile Muscle Fiber Protein Transport Along Microtubule Protein Stabilization Positive Regulation Of Macroautophagy Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Protein Catabolic Process Apoptotic Process Z Disc Negative Regulation Of Protein Metabolic Process Cell Death Programmed Cell Death Aggresome Negative Regulation Of Striated Muscle Cell Apoptotic Process Cytoplasm Positive Regulation Of Autophagy Positive Regulation Of Angiogenesis Negative Regulation Of Protein Kinase C Signaling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ribose-5-phosphate Isomerase Activity Positive Regulation Of Vasculature Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Macroautophagy Response To Mechanical Stimulus	Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Identical Protein Binding Cytoskeleton Structural Constituent Of Skin Epidermis Protein Binding Centrosome Intermediate Filament Keratin Filament Microtubule-based Process Organelle Organization Cytoplasm Protein Localization To Centrosome Centriolar Satellite Cell Differentiation Regulation Of Programmed Cell Death Microtubule Cytoskeleton Organization Microtubule Organizing Center Organization Ureter Morphogenesis Developmental Process Ventral Spinal Cord Development Cellular Developmental Process Transcription Coregulator Binding Structural Molecule Activity Regulation Of Apoptotic Process Thioesterase Binding Epithelial Cell Differentiation Spinal Cord Association Neuron Differentiation Protein Localization To Cytoskeleton Centrosome Cycle Intermediate Filament Cytoskeleton Regulation Of Non-motile Cilium Assembly HMG Box Domain Binding Non-motile Cilium Assembly
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