HSPB8 and BAG3

Number of citations of the paper that reports this interaction (PMID 11591653)
37

Data Source:
HPRD (in vivo)

		HSPB8	BAG3
Gene Name		heat shock 22kDa protein 8	BCL2-associated athanogene 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Cytoplasm Golgi Apparatus	Cytoplasm Cytosol Plasma Membrane Z Disc Neuron Projection
	Molecular Function	Protein Kinase Activity Protein Binding Identical Protein Binding	Protein Binding Protein Complex Binding Chaperone Binding
	Biological Process	Biological_process	Protein Folding Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Negative Regulation Of Apoptotic Process Protein Stabilization Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs
Diseases
GWAS			Dilated cardiomyopathy ( 21459883)
Protein-Protein Interactions		13 interactors: BAG3 CRYAB CSNK2A1 DUSP12 HSPB1 HSPB2 HSPB3 HSPB6 HSPB7 MAPK3 PRKCA QRICH1 SNCA	20 interactors: ACD ARRDC3 BCL2 CRYAB DAZAP2 DVL2 DYNLT1 FAM189A2 HSPA1A HSPA8 HSPB8 LITAF MAGED1 PDE9A PLCG1 POT1 SF3B4 TINF2 TNK2 WNK1
Entrez ID		26353	9531
HPRD ID		06420	04860
Ensembl ID		ENSG00000152137	ENSG00000151929
Uniprot IDs		Q9UJY1	O95817
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Regulation Of Catalytic Activity Cell Death Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Response To Organic Substance Response To Interleukin-1 Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Chromosome Organization Cellular Response To Growth Factor Stimulus Response To External Stimulus Negative Regulation Of Nucleotide Metabolic Process Response To Growth Factor Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Histone Acetylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Cell Activation Negative Regulation Of Peptidase Activity Regulation Of Phosphorylation Positive Regulation Of Endothelial Cell Migration Protein Folding Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Apolipoprotein Binding Positive Regulation Of Dense Core Granule Biogenesis	Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Catalytic Activity Regulation Of Telomere Maintenance Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Cellular Component Organization Negative Regulation Of DNA Replication Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Positive Regulation Of Protein Modification Process Negative Regulation Of DNA Metabolic Process Regulation Of Telomerase Activity Negative Regulation Of Intracellular Transport Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Catalytic Activity Positive Regulation Of DNA Biosynthetic Process Protein Refolding Regulation Of Protein Phosphorylation Regulation Of DNA Replication Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of DNA Metabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Cell Growth Negative Regulation Of Transport Regulation Of Glycoprotein Biosynthetic Process Protein Localization To Chromosome Regulation Of Cellular Response To Heat Positive Regulation Of Protein Metabolic Process Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cellular Process Regulation Of Phosphorylation Regulation Of Organ Morphogenesis Positive Regulation Of Phosphorylation
Tagcloud ?		accordingly ala antiestrogens antiprogestins cdk2 cdks coactivators copurified cos deregulation disrupted g2 insensitive keys lysates pr probed progesterone progestin prs roscovitine s345a ser345 sp1 synchronized t47d talk transcriptionally transiently	athanogene bcl2 cancerous developmentally e3 fnbp4 formin guanylatekinase ligase magi1 modulator nedd4 oncogene oncogenic oxidoreductase pdz property rab2a sgsm3 tumorigenic unchanged wbp2 wbp2nl ww wwox wwp1 wwtr1 yap1 yes
Tagcloud (Difference) ?		accordingly ala antiestrogens antiprogestins cdk2 cdks coactivators copurified cos deregulation disrupted g2 insensitive keys lysates pr probed progesterone progestin prs roscovitine s345a ser345 sp1 synchronized t47d talk transcriptionally transiently	athanogene bcl2 cancerous developmentally e3 fnbp4 formin guanylatekinase ligase magi1 modulator nedd4 oncogene oncogenic oxidoreductase pdz property rab2a sgsm3 tumorigenic unchanged wbp2 wbp2nl ww wwox wwp1 wwtr1 yap1 yes
Tagcloud (Intersection) ?