HSPB8 and TRAPPC6A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSPB8	TRAPPC6A
Description		heat shock protein family B (small) member 8	trafficking protein particle complex subunit 6A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Folding Chaperone Complex	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Cytosol TRAPP Complex TRAPPIII Protein Complex
	Molecular Function	Protein Kinase Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Cellular Response To Unfolded Protein Positive Regulation Of Aggrephagy	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Golgi Vesicle Transport COPII Vesicle Coating Vesicle Tethering
Pathways		HSF1-dependent transactivation	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs			S-palmitoyl-L-cysteine
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS		Metabolite levels ( 23823483) PR interval in Tripanosoma cruzi seropositivity ( 24324551)	Alanine aminotransferase levels ( 33339817) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Aspartate aminotransferase levels ( 33339817) Cerebrospinal fluid AB1-42 levels ( 28247064)
Interacting Genes		21 interacting genes: ATOSB ATXN7L2 BAG3 CATSPERT CRYAB CSNK2A1 DUSP12 HSPB1 HSPB2 HSPB3 HSPB6 HSPB7 MAPK3 MISP PRKCA QRICH1 RPIA SLC16A5 SNCA SOCS7 TRAPPC6A	47 interacting genes: BAG4 CAVIN2 CD2BP2 CRYAB CTDSP1 EFS EYA2 FOXN1 GGA3 GINS3 GOLGA6A GORASP2 HOXA1 HSPB8 IKZF3 INCA1 KANK4 KRTAP13-2 LHX4 MYOZ3 PAX6 PFDN5 PRR22 RAB3IP RAD54B REL RUSC1 SCOC SERTAD3 SF3B5 SMUG1 TAX1BP1 TEPSIN TRAPPC10 TRAPPC12 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC3L TRAPPC6B TRIM35 TTC23 UBAP2 YPEL3 ZFP90 ZMIZ2 ZNRD2
Entrez ID		26353	79090
HPRD ID		06420	14503
Ensembl ID		ENSG00000152137	ENSG00000007255
Uniprot IDs		Q9UJY1	B7TZ90 O75865
PDB IDs		8S7A	2C0J 2J3T
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Protein Refolding Response To Heat Protein Folding Response To Temperature Stimulus Structural Constituent Of Eye Lens Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Unfolded Protein Binding Positive Regulation Of Aggrephagy Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Stability Regulation Of Autophagy Response To Stress Contractile Muscle Fiber Protein Transport Along Microtubule Protein Stabilization Positive Regulation Of Macroautophagy Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Protein Catabolic Process Apoptotic Process Z Disc Negative Regulation Of Protein Metabolic Process Cell Death Programmed Cell Death Aggresome Negative Regulation Of Striated Muscle Cell Apoptotic Process Cytoplasm Positive Regulation Of Autophagy Positive Regulation Of Angiogenesis Negative Regulation Of Protein Kinase C Signaling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ribose-5-phosphate Isomerase Activity Positive Regulation Of Vasculature Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Macroautophagy Response To Mechanical Stimulus	TRAPP Complex TRAPPII Protein Complex Vesicle Tethering Vesicle Coating TRAPPIII Protein Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport COPII Vesicle Coating Intra-Golgi Vesicle-mediated Transport Golgi Apparatus Vesicle Organization Cis-Golgi Network Nucleus Cis-Golgi Network Membrane Negative Regulation Of Amyloid Fibril Formation
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