HSPB8 and SLC16A5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSPB8	SLC16A5
Description		heat shock protein family B (small) member 8	solute carrier family 16 member 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Folding Chaperone Complex	Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity
	Biological Process	Cellular Response To Unfolded Protein Positive Regulation Of Aggrephagy	Monocarboxylic Acid Transport Transmembrane Transport
Pathways		HSF1-dependent transactivation
Drugs			Pyruvic acid
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS		Metabolite levels ( 23823483) PR interval in Tripanosoma cruzi seropositivity ( 24324551)	Bipolar disorder ( 31043756)
Interacting Genes		21 interacting genes: ATOSB ATXN7L2 BAG3 CATSPERT CRYAB CSNK2A1 DUSP12 HSPB1 HSPB2 HSPB3 HSPB6 HSPB7 MAPK3 MISP PRKCA QRICH1 RPIA SLC16A5 SNCA SOCS7 TRAPPC6A	3 interacting genes: EFEMP2 HSPB8 MGAT5B
Entrez ID		26353	9121
HPRD ID		06420	04856
Ensembl ID		ENSG00000152137	ENSG00000170190
Uniprot IDs		Q9UJY1	O15375
PDB IDs		8S7A
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Protein Refolding Response To Heat Protein Folding Response To Temperature Stimulus Structural Constituent Of Eye Lens Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Unfolded Protein Binding Positive Regulation Of Aggrephagy Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Stability Regulation Of Autophagy Response To Stress Contractile Muscle Fiber Protein Transport Along Microtubule Protein Stabilization Positive Regulation Of Macroautophagy Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Protein Catabolic Process Apoptotic Process Z Disc Negative Regulation Of Protein Metabolic Process Cell Death Programmed Cell Death Aggresome Negative Regulation Of Striated Muscle Cell Apoptotic Process Cytoplasm Positive Regulation Of Autophagy Positive Regulation Of Angiogenesis Negative Regulation Of Protein Kinase C Signaling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ribose-5-phosphate Isomerase Activity Positive Regulation Of Vasculature Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Macroautophagy Response To Mechanical Stimulus	Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Positive Regulation Of Aggrephagy Positive Regulation Of Collagen Fibril Organization Elastic Fiber Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Aorta Smooth Muscle Tissue Morphogenesis Regulation Of Collagen Fibril Organization Elastic Fiber Assembly Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Vascular Associated Smooth Muscle Cell Development Microfibril Cellular Response To Unfolded Protein Positive Regulation Of Smooth Muscle Cell Differentiation Protein Homodimerization Activity Cellular Response To Topologically Incorrect Protein Positive Regulation Of Extracellular Matrix Organization Extracellular Matrix Assembly Protein Folding Chaperone Complex Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Aorta Development Artery Development Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Smooth Muscle Cell Proliferation Manganese Ion Binding Regulation Of Extracellular Matrix Organization Muscle Tissue Morphogenesis Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Muscle Cell Differentiation Protein N-linked Glycosylation
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