GATA1 and DNMT3L

Number of citations of the paper that reports this interaction (PubMedID 24952347)
0

Data Source:
BioGRID (pull down)

		GATA1	DNMT3L
Description		GATA binding protein 1	DNA methyltransferase 3 like
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Protein-DNA Complex	Heterochromatin Condensed Nuclear Chromosome Nucleus Cytoplasm Cytosol ESC/E(Z) Complex Catalytic Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Enzyme Activator Activity Zinc Ion Binding Enzyme Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Anatomical Structure Morphogenesis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Regulation Of Primitive Erythrocyte Differentiation Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Eosinophil Differentiation Bone Mineralization Negative Regulation Of Bone Mineralization Animal Organ Regeneration Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Osteoblast Proliferation Positive Regulation Of Osteoblast Proliferation Embryonic Hemopoiesis Eosinophil Fate Commitment Negative Regulation Of Apoptotic Process Positive Regulation Of Mast Cell Degranulation Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development System Development Erythrocyte Development Homeostasis Of Number Of Cells Within A Tissue Sertoli Cell Development Primitive Erythrocyte Differentiation Platelet Aggregation Cellular Response To Lipopolysaccharide Cellular Response To CAMP Cellular Response To Follicle-stimulating Hormone Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Placenta Development DNA Methylation-dependent Constitutive Heterochromatin Formation Male Meiosis I Spermatogenesis Post-embryonic Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Methylation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Epigenetic Programing Of Female Pronucleus Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Chorionic Trophoblast Cell Differentiation Genomic Imprinting Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Autosome Genomic Imprinting Transposable Element Silencing By PiRNA-mediated DNA Methylation
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production	DNA methylation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases		Congenital dyserythropoietic anemias (CDAs) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		86 interacting genes: AKT1 ARID1A ARMC7 ATP6V0D1 BCL6 CASP3 CCDC24 CEBPE CHRD CREBBP DGCR6L DNMT3L FANCG FANCL FBF1 FHL3 FLI1 FRS3 GLRX3 GOLGA2 GRAP2 HDAC3 HDAC4 HDAC5 HEMGN HEXIM2 HEY1 HOXA1 HSPA4 KANK2 KRTAP10-5 KRTAP3-2 KRTAP4-11 KRTAP4-5 KRTAP9-2 LMO2 LZTS2 MAPK1 MAPK3 MAPK6 MDFI MED1 MGAT5B MKRN3 PIAS4 PITX1 PLSCR4 PML PNMA1 PPP1R16B PRKAA1 PRKAB2 PSMF1 RADIL RAI1 RBPMS RIN3 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SP1 SPI1 SPIB SRA1 STAT3 TAF7 TAL1 TAX1BP3 TEKT4 TLE5 TNS2 TRAF1 TRIM25 TRIM29 TRIP6 USP7 ZBTB16 ZBTB22 ZDHHC17 ZFPM1 ZFPM2 ZNF521 ZZZ3	78 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PDZD4 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1
Entrez ID		2623	29947
HPRD ID		02372	09417
Ensembl ID		ENSG00000102145	ENSG00000142182
Uniprot IDs		P15976	Q9UJW3
PDB IDs		6G0Q	2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57 6KDA 6KDB 6KDL 6KDP 6KDT 6U8P 6U8V 6U8W 6U8X 6U90 6U91 6W89 6W8B 6W8D 6W8J 7X9D 8TCI 8XEE
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process NpBAF Complex NBAF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleosome Disassembly Regulation Of G0 To G1 Transition Protein-DNA Complex Disassembly Transcription Coactivator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Brahma Complex RSC-type Complex Regulation Of Nucleotide-excision Repair SWI/SNF Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process BBAF Complex Protein Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Positive Regulation Of Double-strand Break Repair DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Lymphocyte Differentiation Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Myoblast Differentiation Nucleoplasm Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Regulation Of Double-strand Break Repair Regulation Of Myoblast Differentiation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of T Cell Differentiation Chromatin Remodeling	DNA-binding Transcription Factor Activity Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Cell Differentiation Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process DNA-templated Transcription Positive Regulation Of MiRNA Transcription Cellular Developmental Process
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