GATA1 and HEXIM2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GATA1	HEXIM2
Gene Name		GATA binding protein 1 (globin transcription factor 1)	hexamethylene bis-acetamide inducible 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Transcriptional Repressor Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding Enhancer Sequence-specific DNA Binding P53 Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding DNA Binding, Bending Chromatin DNA Binding Sequence-specific DNA Binding C2H2 Zinc Finger Domain Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription From RNA Polymerase II Promoter Cell-cell Signaling Blood Coagulation Negative Regulation Of Cell Proliferation Male Gonad Development Regulation Of Glycoprotein Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Eosinophil Differentiation Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Proliferation Embryonic Hemopoiesis Eosinophil Fate Commitment Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Platelet Aggregation Transcriptional Activation By Promoter-enhancer Looping Dendritic Cell Differentiation Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Systolic blood pressure ( 19430483)
Protein-Protein Interactions		51 interactors: AKT1 ARID1A CASP3 CCDC24 CEBPE CREBBP FBF1 FLI1 FRS3 HDAC3 HDAC4 HDAC5 HEXIM2 HEY1 HOXA1 HSPA4 KRTAP10-5 KRTAP9-2 LMO2 MAPK1 MAPK3 MAPK6 MED1 PRKAA1 PRKAB2 RADIL RAI1 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SP1 SPI1 SPIB SRA1 STAT3 SUMO1 TAF7 TAL1 TAX1BP3 TRIM25 TRIM29 ZBTB16 ZBTB22 ZDHHC17 ZFPM1 ZFPM2 ZNF521 ZZZ3	15 interactors: CCDC36 CCNT1 CDK9 GATA1 MEOX2 PIM1 PIN1 PRDM14 RNPS1 SPRY1 SPRY2 TADA3 TCF12 TERF1 TERF2
Entrez ID		2623	124790
HPRD ID		02372	08129
Ensembl ID		ENSG00000102145	ENSG00000168517
Uniprot IDs		P15976	Q96MH2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Gene Expression RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Biosynthetic Process Nucleosome Disassembly Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Developmental Process Chromatin Organization Regulation Of Cellular Process Anatomical Structure Development Chromatin Remodeling Myeloid Cell Differentiation Chromatin Modification Cell Differentiation Multicellular Organismal Development Embryonic Organ Development Hemopoiesis Chromosome Organization Megakaryocyte Differentiation Immune System Development	Regulation Of Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cell Cycle Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Regulation Of Protein Phosphorylation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Telomere Maintenance Via Telomere Shortening Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of DNA Replication Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Cellular Macromolecule Biosynthetic Process Negative Regulation Of ERK1 And ERK2 Cascade Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Transcription From RNA Polymerase II Promoter Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Positive Regulation Of Gene Expression Replicative Cell Aging Transcription, DNA-templated Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Bud Elongation Involved In Lung Branching RNA Biosynthetic Process Nitrogen Compound Metabolic Process Cell Fate Commitment Negative Regulation Of DNA Metabolic Process Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Mitotic Cell Cycle Negative Regulation Of Ras GTPase Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Telomere Maintenance Regulation Of DNA Replication Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		alls blasts cd3 cd45 comprised deregulation disrupted enable exploited fused haemopoietic immunocytochemical leukaemia leukaemic lymphoblastic lymphoid monocytes morphologically ordinately origin precursors rearrangement resembled sil tal tal1 transcripts unexplained unidentified
Tagcloud (Difference) ?		alls blasts cd3 cd45 comprised deregulation disrupted enable exploited fused haemopoietic immunocytochemical leukaemia leukaemic lymphoblastic lymphoid monocytes morphologically ordinately origin precursors rearrangement resembled sil tal tal1 transcripts unexplained unidentified
Tagcloud (Intersection) ?