HACL1 and PEX5

Number of citations of the paper that reports this interaction (PubMedID 22002062)
71

Data Source:
BioGRID (affinity chromatography technology, unspecified method, affinity chromatography technology)

		HACL1	PEX5
Description		2-hydroxyacyl-CoA lyase 1	peroxisomal biogenesis factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Peroxisome Peroxisomal Matrix Cytosol	Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Golgi Apparatus Cytosol Membrane Protein-containing Complex
	Molecular Function	Magnesium Ion Binding Catalytic Activity Protein Binding ATP Binding Lyase Activity Carbon-carbon Lyase Activity Thiamine Pyrophosphate Binding Identical Protein Binding Metal Ion Binding 2-hydroxyacyl-CoA Lyase Activity 2-hydroxyphytanoyl-CoA Lyase Activity	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein Carrier Chaperone
	Biological Process	Fatty Acid Alpha-oxidation Protein Targeting To Peroxisome Lipid Metabolic Process Fatty Acid Metabolic Process Methyl-branched Fatty Acid Metabolic Process Phytanic Acid Metabolic Process	Very Long-chain Fatty Acid Metabolic Process Pexophagy Neuron Migration Protein Monoubiquitination Protein Targeting To Peroxisome Lipid Metabolic Process Fatty Acid Beta-oxidation Mitochondrion Organization Mitochondrial Membrane Organization Endoplasmic Reticulum Organization Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Cerebral Cortex Cell Migration Cerebral Cortex Neuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Reactive Oxygen Species Positive Regulation Of Multicellular Organism Growth Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Membrane Cell Development Neuromuscular Process Protein Tetramerization
Pathways		Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import	Pexophagy
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		C-reactive protein levels ( 29878111)	IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: CFTR MAGEB6 MAPK6 PEX5 ZMYND19	77 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 NUFIP2 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772
Entrez ID		26061	5830
HPRD ID		09183	02684
Ensembl ID		ENSG00000131373	ENSG00000139197
Uniprot IDs		B4DXR1 Q9UJ83	A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542
PDB IDs			1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO 7Z0K 9GAG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Protein-containing Complex Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Septin Cytoskeleton Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Positive Regulation Of Enamel Mineralization Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Positive Regulation Of Developmental Process Golgi-associated Vesicle Membrane Protein Unfolding Protein Import Into Peroxisome Matrix Cellular Response To Forskolin Response To Forskolin MAP Kinase Activity Pexophagy Enzyme Binding Chloride Transmembrane Transporter Activity Sperm Capacitation Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Cerebral Cortex Neuron Differentiation Bicarbonate Transport	Peroxisome Peroxisomal Matrix Carboxylic Acid Catabolic Process Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Fatty Acid Oxidation Carboxylic Acid Metabolic Process Fatty Acid Catabolic Process Organic Acid Metabolic Process Lipid Oxidation Peroxisome Organization Fatty Acid Metabolic Process Monocarboxylic Acid Metabolic Process Peroxisomal Membrane Transport Peroxisomal Membrane Lipid Modification Protein Import Into Peroxisome Matrix, Receptor Recycling Intracellular Protein Transmembrane Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Small Molecule Metabolic Process Lipid Metabolic Process Protein Unfolding Lipid Catabolic Process Protein Transmembrane Transport Catabolic Process Fatty Acid Beta-oxidation Receptor Recycling Protein Targeting To Peroxisome Cytosol Establishment Of Protein Localization To Organelle Receptor Metabolic Process Sulfur Compound Metabolic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Protein Import Into Peroxisome Matrix, Substrate Release Bile Acid Metabolic Process Fatty Acid Alpha-oxidation Oxidoreductase Activity Protein Localization To Organelle Purine-containing Compound Metabolic Process Small Molecule Biosynthetic Process Peroxisomal Importomer Complex Malonyl-CoA Catabolic Process Protein Transmembrane Transporter Activity Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Import Into Peroxisome Matrix, Translocation Telomere Assembly Organophosphate Metabolic Process
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