HACL1 and ZMYND19

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		HACL1	ZMYND19
Description		2-hydroxyacyl-CoA lyase 1	zinc finger MYND-type containing 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Peroxisome Peroxisomal Matrix Cytosol	Cytoplasm Plasma Membrane Membrane Synapse
	Molecular Function	Magnesium Ion Binding Catalytic Activity Protein Binding ATP Binding Lyase Activity Carbon-carbon Lyase Activity Thiamine Pyrophosphate Binding Identical Protein Binding Metal Ion Binding 2-hydroxyacyl-CoA Lyase Activity 2-hydroxyphytanoyl-CoA Lyase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Fatty Acid Alpha-oxidation Protein Targeting To Peroxisome Lipid Metabolic Process Fatty Acid Metabolic Process Methyl-branched Fatty Acid Metabolic Process Phytanic Acid Metabolic Process
Pathways		Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS		C-reactive protein levels ( 29878111)	Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Systolic blood pressure ( 30578418)
Interacting Genes		5 interacting genes: CFTR MAGEB6 MAPK6 PEX5 ZMYND19	53 interacting genes: ACTMAP ANKRD55 CCNI CEACAM6 CPSF6 DTX3 ENOX1 FIP1L1 FNDC3B GAPDHS GGN GID4 GMEB2 GORASP2 GRB10 GSE1 GTF2F2 HACL1 HOMEZ INCA1 KCTD13 KCTD21 LZTS1 LZTS2 MCHR1 MLLT6 NAB2 PNMA5 PPP1R37 PRKAB2 PRKAR1B PRMT5 PSMA1 PTGES3L-AARSD1 RFX6 SAXO1 SCN5A SELENOV SS18L1 TBRG1 TNFAIP1 TNNT1 TOLLIP TOX4 TRIM27 TRIM45 TUBB WDR77 ZBTB2 ZNG1A ZNG1C ZNG1E ZXDC
Entrez ID		26061	116225
HPRD ID		09183	15743
Ensembl ID		ENSG00000131373	ENSG00000165724
Uniprot IDs		B4DXR1 Q9UJ83	Q96E35
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Protein-containing Complex Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Septin Cytoskeleton Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Positive Regulation Of Enamel Mineralization Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Positive Regulation Of Developmental Process Golgi-associated Vesicle Membrane Protein Unfolding Protein Import Into Peroxisome Matrix Cellular Response To Forskolin Response To Forskolin MAP Kinase Activity Pexophagy Enzyme Binding Chloride Transmembrane Transporter Activity Sperm Capacitation Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Cerebral Cortex Neuron Differentiation Bicarbonate Transport
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