NECAP1 and DNAJC5

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NECAP1	DNAJC5
Description		NECAP endocytosis associated 1	DnaJ heat shock protein family (Hsp40) member C5
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Presynapse	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse
	Molecular Function	Protein Binding	Protein Binding ATP-dependent Protein Binding
	Biological Process	Endocytosis Protein Transport Vesicle-mediated Transport Presynaptic Endocytosis	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS			Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		10 interacting genes: AMPH AP1B1 APP DAB2 DAPK1 DNAJC5 HIP1 REL SNAP91 SNCA	49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		25977	80331
HPRD ID		14819	08539
Ensembl ID		ENSG00000089818	ENSG00000101152
Uniprot IDs		Q8NC96	Q9H3Z4
PDB IDs		6RH5 6RH6	2N04 2N05
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Vesicle-mediated Transport Endocytosis Regulation Of Vesicle-mediated Transport Clathrin Coat Assembly Phospholipid Binding Import Into Cell Regulation Of Receptor-mediated Endocytosis Regulation Of Endocytosis Clathrin Binding Clathrin-coated Vesicle Membrane Positive Regulation Of Endocytosis Cytoplasmic Vesicle Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis Programmed Cell Death Cell Death Regulation Of Transport Presynapse Clathrin-coated Pit Clathrin-coated Vesicle Vesicle-mediated Transport In Synapse Clathrin Adaptor Activity Regulation Of Clathrin-dependent Endocytosis Regulation Of Apoptotic Process Synaptic Vesicle Membrane Regulation Of Neurotransmitter Uptake Regulation Of Programmed Cell Death Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Positive Regulation Of Small Molecule Metabolic Process Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Receptor-mediated Endocytosis Amyloid Fibril Formation Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Response To Copper Ion Response To Cytokine Positive Regulation Of Catabolic Process Response To Peptide Synaptic Vesicle Endocytosis Postsynapse Presynaptic Endocytosis Regulation Of Neuron Apoptotic Process Protein-containing Complex Assembly Actin Cytoskeleton	Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation
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