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GEMIN5 and MAP2K4
Number of citations of the paper that reports this interaction (PMID
17541429
)
5
Data Source:
BioGRID
(pull down)
GEMIN5
MAP2K4
Gene Name
gem (nuclear organelle) associated protein 5
mitogen-activated protein kinase kinase 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Nuclear Body
SMN Complex
SMN-Sm Protein Complex
Gemini Of Coiled Bodies
Intracellular
Nucleus
Cytosol
Axon
Dendrite Cytoplasm
Perikaryon
Molecular Function
Protein Binding
SnRNA Binding
Poly(A) RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
JUN Kinase Kinase Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Biological Process
Spliceosomal SnRNP Assembly
MRNA Splicing, Via Spliceosome
Protein Complex Assembly
Gene Expression
NcRNA Metabolic Process
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Signal Transduction
JNK Cascade
Activation Of JUN Kinase Activity
Pathogenesis
Peptidyl-tyrosine Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Innate Immune Response
Positive Regulation Of DNA Replication
Stress-activated MAPK Cascade
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Mechanical Stimulus
Cellular Response To Sorbitol
Pathways
snRNP Assembly
Metabolism of non-coding RNA
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
Uptake and actions of bacterial toxins
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Uptake and function of anthrax toxins
Innate Immune System
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
Cytokine Signaling in Immune system
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Signaling by Interleukins
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Oxidative Stress Induced Senescence
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
Interleukin-1 signaling
Drugs
Diseases
GWAS
Response to amphetamines (
22952603
)
Protein-Protein Interactions
19 interactors:
DDX20
EIF4E
GEMIN2
GEMIN4
MAP2K4
MAP3K5
MAPK8
RN7SL1
RNU1-1
RNU2-1
SMN1
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SNRPG
STXBP3
37 interactors:
AKT1
APP
ARRB1
ARRB2
CFLAR
DUSP22
EFNA4
FLNA
FLNC
GEMIN5
ITCH
JUN
LRRK2
MAP2K6
MAP3K1
MAP3K10
MAP3K11
MAP3K12
MAP3K14
MAP3K2
MAP3K3
MAP3K4
MAP3K5
MAP3K7
MAP3K8
MAP4K2
MAPK1
MAPK10
MAPK12
MAPK14
MAPK8
MAPK8IP3
MAPK9
RBBP8
SPAG9
TRIB1
ZAK
Entrez ID
25929
6416
HPRD ID
06109
03213
Ensembl ID
ENSG00000082516
ENSG00000065559
Uniprot IDs
B7ZLC9
Q58EZ8
Q8TEQ6
B7ZA62
P45985
PDB IDs
3ALN
3ALO
3VUT
Enriched GO Terms of Interacting Partners
?
Spliceosomal SnRNP Assembly
Ribonucleoprotein Complex Assembly
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
MRNA Processing
Ribonucleoprotein Complex Biogenesis
RNA Splicing
MRNA Metabolic Process
RNA Processing
NcRNA Metabolic Process
Cellular Macromolecular Complex Assembly
Histone MRNA Metabolic Process
Spliceosomal Complex Assembly
MRNA 3'-end Processing
Termination Of RNA Polymerase II Transcription
RNA 3'-end Processing
Cellular Component Assembly
DNA-templated Transcription, Termination
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
JNK Cascade
Cellular Metabolic Process
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Cellular Response To Reactive Nitrogen Species
Transcription From RNA Polymerase II Promoter
Activation Of JUN Kinase Activity
Programmed Necrotic Cell Death
MAPK Cascade
Necrotic Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Positive Regulation Of Cell Death
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Cellular Response To Hydrogen Peroxide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Signal Transduction By Phosphorylation
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
Signal Transduction By Phosphorylation
Regulation Of MAPK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of MAPK Cascade
Activation Of MAPK Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Activation Of Protein Kinase Activity
Regulation Of MAP Kinase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
JNK Cascade
Positive Regulation Of Protein Phosphorylation
Regulation Of Intracellular Signal Transduction
Activation Of MAPKK Activity
Positive Regulation Of Phosphorylation
Regulation Of Protein Kinase Activity
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Kinase Activity
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Regulation Of Catalytic Activity
Positive Regulation Of Transferase Activity
Regulation Of Signal Transduction
Phosphorylation
Regulation Of Signaling
Regulation Of JNK Cascade
Protein Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Phosphate-containing Compound Metabolic Process
Positive Regulation Of JUN Kinase Activity
Cell Death
Death
Positive Regulation Of JNK Cascade
Regulation Of JUN Kinase Activity
Tagcloud
?
aurka
aurkb
bioinformatics
cdkn2a
copy
custom
describing
epha5
flt4
frameshift
insertions
interrogating
kdm6a
leiomyosarcomas
locally
losses
multiplexed
nf1
ngs
notch1
pdgfrb
pik3ca
pipeline
rationale
rb1
sarcomas
soft
stratification
targetable
Tagcloud (Difference)
?
aurka
aurkb
bioinformatics
cdkn2a
copy
custom
describing
epha5
flt4
frameshift
insertions
interrogating
kdm6a
leiomyosarcomas
locally
losses
multiplexed
nf1
ngs
notch1
pdgfrb
pik3ca
pipeline
rationale
rb1
sarcomas
soft
stratification
targetable
Tagcloud (Intersection)
?