COG4 and FARSA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COG4	FARSA
Description		component of oligomeric golgi complex 4	phenylalanyl-tRNA synthetase subunit alpha
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane Golgi Transport Complex Trans-Golgi Network Membrane	Cytoplasm Cytosol Phenylalanine-tRNA Ligase Complex Membrane
	Molecular Function	Protein Binding Identical Protein Binding	TRNA Binding Nucleotide Binding Magnesium Ion Binding RNA Binding Aminoacyl-tRNA Ligase Activity Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding
	Biological Process	Retrograde Transport, Vesicle Recycling Within Golgi Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Glycosylation	Translation Phenylalanyl-tRNA Aminoacylation TRNA Aminoacylation Protein Heterotetramerization
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Cytosolic tRNA aminoacylation
Drugs			Phenylalanine
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Liver enzyme levels (alkaline phosphatase) ( 33972514) Malaria ( 31844061) Menarche (age at onset) ( 25231870) Weight ( 28552196)	Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Type 2 diabetes ( 30297969)
Interacting Genes		20 interacting genes: ANKRD11 APC BEX2 COG1 COG2 COG5 COG7 CTNNA3 DSCAM FAM110A FARSA ITSN1 MTNR1B NRIP1 PSMA1 RSPH1 SEPTIN2 SORBS3 TTC3 TXNDC9	13 interacting genes: A2M ABI3 APOE COG4 CRIPTO ECSIT ESR1 GORAB HNRNPR OGT PDCD10 PTEN RNF32
Entrez ID		25839	2193
HPRD ID		08444	04227
Ensembl ID		ENSG00000103051	ENSG00000179115
Uniprot IDs		A0A0A0MS45 A0A6I8PIQ6 J3KNI1 Q8N8L9 Q9H9E3	Q6IBR2 Q9Y285
PDB IDs		3HR0	3L4G
Enriched GO Terms of Interacting Partners?		Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Intra-Golgi Vesicle-mediated Transport Trans-Golgi Network Membrane Golgi Organization Glycosylation Golgi Vesicle Transport	Negative Regulation Of Cell Migration Regulation Of Cell Migration Lipid Binding Regulation Of Locomotion Negative Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Oxidoreductase Activity Negative Regulation Of Locomotion Enzyme Binding Regulation Of Innate Immune Response Positive Regulation Of Proteolysis Negative Regulation Of Phospholipid Efflux Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Anatomical Structure Morphogenesis Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Metal Chelating Activity Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Cell Projection Organization Intermediate-density Lipoprotein Particle Clearance Regulation Of Catalytic Activity Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cellular Senescence Regulation Of Phosphorus Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of MAP Kinase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Endothelial Cell Proliferation Cellular Component Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Rhythmic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Junction Assembly Regulation Of Nitric Oxide Biosynthetic Process Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Negative Regulation Of Complement Activation, Lectin Pathway
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