COG4 and BEX2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		COG4	BEX2
Name		component of oligomeric golgi complex 4	brain expressed X-linked 2
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane Golgi Transport Complex Trans-Golgi Network Membrane	Nucleus Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding	Signaling Receptor Binding Protein Binding Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	Retrograde Transport, Vesicle Recycling Within Golgi Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Glycosylation	Apoptotic Process Signal Transduction Negative Regulation Of Protein Ubiquitination Regulation Of Apoptotic Process Regulation Of Cell Cycle
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Malaria ( 31844061 ) Menarche (age at onset) ( 25231870 ) Weight ( 28552196 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: PLA2G15	None recorded
Interacting Genes		20 interacting genes: ANKRD11 APC BEX2 COG1 COG2 COG5 COG7 CTNNA3 DSCAM FAM110A FARSA ITSN1 MTNR1B NRIP1 PSMA1 RSPH1 SEPTIN2 SORBS3 TTC3 TXNDC9	92 interacting genes: AKAP9 AURKA BCAR3 BLZF1 BORCS6 BRMS1 CCDC197 CCDC57 CCDC85B CCDC88B CDR2 CEP70 COG4 CTAG1A CTAG1B CYSRT1 EXOC8 FGFR2 FSD2 FST GPRASP3 HSF2BP HSPB2 HSPB2-C11orf52 KLHL20 KNSTRN KRT15 KRT19 KRT27 KRT31 KRT34 KRT38 KRT39 KRT40 KRT6A KRT75 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-3 KRTAP4-12 KRTAP5-9 KRTAP6-2 KRTAP6-3 LCN2 LDOC1 LMO2 LZTS2 MAGEA11 MAGEA2 MAGEA2B MAGEA4 MDFI MIPOL1 MKRN3 MORN3 MRPL38 MSS51 MTUS2 NECAB2 NFKBID OIP5 OMP PIK3CA PLA2G10 PLEKHG4 PNMA1 PPM1D PRDM14 PTPN11 ROPN1L SERTAD3 SPRED1 SPRY3 SSX2IP SYCE1 TACC3 TRAF1 TRAF2 TRIM27 TRIM42 TRIM69 TRIM73 TRIP6 USHBP1 VHL VPS28 ZDHHC17 ZNF19
Entrez ID		25839	84707
HPRD ID		08444	06484
Ensembl ID		ENSG00000103051	ENSG00000133134
Uniprot IDs		A0A0A0MS45 A0A6I8PIQ6 J3KNI1 Q8N8L9 Q9H9E3	Q9BXY8
PDB IDs		3HR0	Not available
GO Terms Enriched among Interactors		Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Intra-Golgi Vesicle-mediated Transport Trans-Golgi Network Membrane Golgi Organization Glycosylation Golgi Vesicle Transport	Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Molecule Activity Protein Binding Cytoskeleton Organization Supramolecular Fiber Organization Cytosol Morphogenesis Of An Epithelium Hair Follicle Morphogenesis Cytoskeleton Identical Protein Binding Epithelial Cell Differentiation Tissue Morphogenesis Negative Regulation Of Protein Acetylation Microtubule Organizing Center Anatomical Structure Morphogenesis Organelle Organization Keratinization