COG4 and COG5

Number of citations: 48 (PubMedID 11980916)
Data Source: HPRD (in vivo, in vitro)

		COG4	COG5
Name		component of oligomeric golgi complex 4	component of oligomeric golgi complex 5
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane Golgi Transport Complex Trans-Golgi Network Membrane	Golgi Membrane Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Golgi Transport Complex Trans-Golgi Network Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Retrograde Transport, Vesicle Recycling Within Golgi Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Glycosylation	Retrograde Transport, Vesicle Recycling Within Golgi Intra-Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Inter-Golgi Cisterna Vesicle-mediated Transport Glycosylation
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
GWAS		Brain morphology (MOSTest) ( 32665545 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Malaria ( 31844061 ) Menarche (age at onset) ( 25231870 ) Weight ( 28552196 )	Apolipoprotein A1 levels ( 32203549 ) Atrial fibrillation ( 29892015 ) Daytime nap ( 33568662 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) HDL cholesterol levels ( 32203549 ) LDL cholesterol ( 30275531 ) Macular thickness ( 30535121 ) Medication use (beta blocking agents) ( 31015401 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 32888494 ) Osteoarthritis ( 20112360 ) Pulse pressure ( 30578418 30224653 ) Serum alkaline phosphatase levels ( 33339817 33547301 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Novel Interactors		1 novel interactors: PLA2G15	None recorded
Interacting Genes		20 interacting genes: ANKRD11 APC BEX2 COG1 COG2 COG5 COG7 CTNNA3 DSCAM FAM110A FARSA ITSN1 MTNR1B NRIP1 PSMA1 RSPH1 SEPTIN2 SORBS3 TTC3 TXNDC9	5 interacting genes: APC COG4 COG7 MEFV RAC1
Entrez ID		25839	10466
HPRD ID		08444	08436
Ensembl ID		ENSG00000103051	ENSG00000164597
Uniprot IDs		A0A0A0MS45 A0A6I8PIQ6 J3KNI1 Q8N8L9 Q9H9E3	A0AAA9X096 A0AAA9X2X8 Q9UP83
PDB IDs		3HR0	Not available
GO Terms Enriched among Interactors		Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Intra-Golgi Vesicle-mediated Transport Trans-Golgi Network Membrane Golgi Organization Glycosylation Golgi Vesicle Transport	Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Lamellipodium Intra-Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Microtubule Polymerization Or Depolymerization Ruffle Membrane Pyroptosome Complex Assembly Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Golgi Organization Trans-Golgi Network Membrane Negative Regulation Of Cellular Component Organization Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Glycosylation Cell-cell Junction Organization Regulation Of Ovarian Follicle Development Erythrocyte Enucleation Regulation Of Cell Projection Assembly Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Auditory Receptor Cell Morphogenesis Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Regulation Of Microtubule-based Process Leading Edge Membrane Wnt Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Centrosome Kinocilium Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Interleukin-23 Production G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Neuron Maturation Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Thioesterase Binding Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Vesicle-mediated Transport Golgi Vesicle Transport Wnt Signalosome Positive Regulation Of Pseudopodium Assembly Beta-catenin Destruction Complex