COG4 and SEPTIN2

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		COG4	SEPTIN2
Name		component of oligomeric golgi complex 4	septin 2
Structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane Golgi Transport Complex Trans-Golgi Network Membrane	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Plasma Membrane Cilium Axoneme Cell Cortex Septin Ring Cell Surface Actin Cytoskeleton Microtubule Cytoskeleton Membrane Midbody Septin Complex Motile Cilium Cell Division Site Cleavage Furrow Photoreceptor Connecting Cilium Ciliary Transition Zone Cell Projection Intercellular Bridge Synapse Ciliary Membrane Extracellular Exosome Sperm Annulus Non-motile Cilium
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Enzyme Regulator Activity Identical Protein Binding Cadherin Binding Molecular Adaptor Activity
	Biological Process	Retrograde Transport, Vesicle Recycling Within Golgi Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Glycosylation	Regulation Of L-glutamate Import Across Plasma Membrane Smoothened Signaling Pathway Spermatogenesis Intracellular Protein Localization Cell Differentiation Regulation Of Protein Localization Cell Division Cilium Assembly Cytoskeleton-dependent Cytokinesis
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Anchoring of the basal body to the plasma membrane
GWAS		Brain morphology (MOSTest) ( 32665545 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Malaria ( 31844061 ) Menarche (age at onset) ( 25231870 ) Weight ( 28552196 )	Liver enzyme levels (alkaline phosphatase) ( 33972514 )
Novel Interactors		1 novel interactors: PLA2G15	2 novel interactors: COL6A3 NGEF
Interacting Genes		20 interacting genes: ANKRD11 APC BEX2 COG1 COG2 COG5 COG7 CTNNA3 DSCAM FAM110A FARSA ITSN1 MTNR1B NRIP1 PSMA1 RSPH1 SEPTIN2 SORBS3 TTC3 TXNDC9	25 interacting genes: ATP6V0D2 BAZ2B CDC42 CEBPA COG4 CSNK2A1 DAZAP2 DSCAM ESR1 FXR1 JPT2 MTOR PIK3R2 PLEKHF2 RNF31 S100A4 SEPTIN5 SEPTIN6 SEPTIN9 SH3KBP1 SNCA STMN1 STX1A TBC1D21 UBL5
Entrez ID		25839	4735
HPRD ID		08444	03297
Ensembl ID		ENSG00000103051	ENSG00000168385
Uniprot IDs		A0A0A0MS45 A0A6I8PIQ6 J3KNI1 Q8N8L9 Q9H9E3	A0A384N6H6 B5MCX3 Q15019
PDB IDs		3HR0	2QA5 2QAG 2QNR 6UPA 6UPQ 6UPR 7M6J
GO Terms Enriched among Interactors		Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Intra-Golgi Vesicle-mediated Transport Trans-Golgi Network Membrane Golgi Organization Glycosylation Golgi Vesicle Transport	Cell Division Site Septin Ring Septin Complex Identical Protein Binding Organelle Organization Regulation Of Stress Fiber Assembly Cytoskeleton-dependent Cytokinesis Regulation Of Autophagy Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Synaptic Vesicle Positive Regulation Of Cell Growth Regulation Of Intracellular Signal Transduction Cell Differentiation Golgi Transport Complex Protein Destabilization Regulation Of Cytoskeleton Organization SNARE Complex Assembly Neuron Projection Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Catabolic Process Molecular Adaptor Activity Intracellular Protein Localization Negative Regulation Of Microtubule Polymerization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macroautophagy Regulation Of Signal Transduction Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Neurotransmitter Secretion Regulation Of Organelle Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neurotransmitter Secretion Regulation Of Cell Projection Assembly Regulation Of Cell Projection Organization Positive Regulation Of Growth Regulation Of Actin Filament Organization Cellular Developmental Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Synaptic Vesicle Exocytosis Positive Regulation Of Protein Targeting To Mitochondrion