SNX33 and DPPA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNX33	DPPA4
Description		sorting nexin 33	developmental pluripotency associated 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Phosphatidylinositol Binding Identical Protein Binding	Chromatin Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Endosome Organization Positive Regulation Of Catabolic Process Protein Transport Endosomal Transport Protein Import Cleavage Furrow Formation Macropinocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cell Division Plasma Membrane Tubulation Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Localization To Cell Surface	System Development Lung-associated Mesenchyme Development
Pathways			POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462)	Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: ADAM15 DPPA4 FASLG FBXO7 NAA10 NAF1 PAK2 ZNF575	37 interacting genes: BTBD2 CIRSR CRK DPPA2 EAF1 EIF4A2 EMD FOXR1 GMPPB GRAP GRB2 GTPBP3 HTT INO80B KAT14 LDOC1 MAGOH MAP1LC3A MAP1LC3B MAPK6 MISP NEDD9 OSTF1 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 SNX18 SNX33 SPANXN2 TLK1 TNIP1 VIM
Entrez ID		257364	55211
HPRD ID		11331	16836
Ensembl ID		ENSG00000173548	ENSG00000121570
Uniprot IDs		Q8WV41	Q7L190
PDB IDs		4AKV
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Protein-N-terminal-alanine Acetyltransferase Activity Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Protein-N-terminal-glutamate Acetyltransferase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Box H/ACA SnoRNP Assembly Retinal Cell Programmed Cell Death Protein N-terminal-serine Acetyltransferase Activity Lewy Body Core SnoRNA Guided RRNA Pseudouridine Synthesis Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion NatA Complex Negative Regulation Of Receptor Binding Response To Hypobaric Hypoxia Telomerase RNA Stabilization Regulation Of Extrinsic Apoptotic Signaling Pathway Inflammatory Cell Apoptotic Process Protein-N-terminal Amino-acid Acetyltransferase Activity Telomerase Holoenzyme Complex Assembly	Phosphotyrosine Residue Binding Cytoplasm Protein Binding Cellular Response To Muramyl Dipeptide Cellular Response To Nitrogen Starvation Cleavage Furrow Formation Import Into Cell Endocytosis Central Nervous System Development Phosphatidylethanolamine Binding Plasma Membrane Tubulation Organelle Organization Spindle Pole Centrosome
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