SNX33 and FASLG

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology)

		SNX33	FASLG
Description		sorting nexin 33	Fas ligand
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol Binding Identical Protein Binding	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Endosome Organization Positive Regulation Of Catabolic Process Protein Transport Endosomal Transport Protein Import Cleavage Furrow Formation Macropinocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cell Division Plasma Membrane Tubulation Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Localization To Cell Surface	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Intracellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Cellular Response To Type II Interferon Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Interleukin-4 and Interleukin-13 signaling Dimerization of procaspase-8 FasL/ CD95L signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models FOXO-mediated transcription of cell death genes TNFs bind their physiological receptors
Drugs
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Estimated glomerular filtration rate ( 31015462)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 30013184) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 24999842 25920553 20190752) Crohn's disease ( 21102463 23128233) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Psoriasis ( 28537254) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		8 interacting genes: ADAM15 DPPA4 FASLG FBXO7 NAA10 NAF1 PAK2 ZNF575	82 interacting genes: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK CYSRT1 DAXX DLG2 DMD DNMBP DOCK4 ECM1 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB1 FYN GRAP GRAP2 GRB2 HCK IHO1 ITK ITSN2 KALRN KMT2A KRT33B KRT40 KRTAP11-1 KRTAP12-3 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NLA OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SEC23A SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TNS2 TRIP6 YES1
Entrez ID		257364	356
HPRD ID		11331	00610
Ensembl ID		ENSG00000173548	ENSG00000117560
Uniprot IDs		Q8WV41	P48023 Q53ZZ1
PDB IDs		4AKV	4MSV 5L19 5L36
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Protein-N-terminal-alanine Acetyltransferase Activity Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Protein-N-terminal-glutamate Acetyltransferase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Box H/ACA SnoRNP Assembly Retinal Cell Programmed Cell Death Protein N-terminal-serine Acetyltransferase Activity Lewy Body Core SnoRNA Guided RRNA Pseudouridine Synthesis Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion NatA Complex Negative Regulation Of Receptor Binding Response To Hypobaric Hypoxia Telomerase RNA Stabilization Regulation Of Extrinsic Apoptotic Signaling Pathway Inflammatory Cell Apoptotic Process Protein-N-terminal Amino-acid Acetyltransferase Activity Telomerase Holoenzyme Complex Assembly	Phosphotyrosine Residue Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Antigen Receptor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Activation Of Immune Response Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Protein Tyrosine Kinase Activity Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Organization Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Binding Peptidyl-tyrosine Phosphorylation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Cell Shape Regulation Of Cell Morphogenesis Negative Regulation Of Immune System Process Regulation Of Actin Filament-based Process Positive Regulation Of Immune System Process T Cell Costimulation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Regulation Of Signal Transduction Developmental Process Phospholipase Activator Activity Endocytosis B Cell Receptor Signaling Pathway Regulation Of Cell Motility Immune System Process Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Anchoring Junction Positive Regulation Of T Cell Activation
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