GABRR1 and P2RX2

Number of citations of the paper that reports this interaction (PubMedID 14660627)
0

Data Source:
HPRD (in vivo, in vitro)

		GABRR1	P2RX2
Description		gamma-aminobutyric acid type A receptor subunit rho1	purinergic receptor P2X 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex Presynaptic Membrane Synapse Postsynaptic Membrane Intracellular Vesicle Glutamatergic Synapse GABA-ergic Synapse GABA-A Receptor Complex	Plasma Membrane Membrane Apical Plasma Membrane Neuronal Cell Body Receptor Complex Synapse Postsynapse Neuronal Dense Core Vesicle
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA Receptor Activity Protein Domain Specific Binding GABA-gated Chloride Ion Channel Activity Identical Protein Binding Protein-containing Complex Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity ATP Binding Ligand-gated Monoatomic Ion Channel Activity Identical Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Synaptic Transmission, GABAergic Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport	Response To Hypoxia Response To Ischemia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Monoatomic Ion Transport Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Neuromuscular Junction Development Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport
Pathways		GABA receptor activation	Elevation of cytosolic Ca2+ levels Platelet homeostasis
Drugs		Lindane Picrotoxin Fludiazepam TPMPA	Promethazine
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder and schizophrenia ( 20889312) Diabetic kidney disease in type 2 diabetes ( 29703844) Early diabetic kidney disease in type 2 diabetes ( 29703844) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)	Body mass index ( 26426971)
Interacting Genes		10 interacting genes: CSNK2A1 GABRR2 MAP1B MAPK1 P2RX2 PRKACA PRKCA PRKG1 SLC6A9 SQSTM1	4 interacting genes: GABRA1 GABRR1 P2RX1 P2RX3
Entrez ID		2569	22953
HPRD ID		15921	15984
Ensembl ID		ENSG00000146276	ENSG00000187848
Uniprot IDs		P24046	Q32MC3 Q9UBL9
PDB IDs		8OP9 8OQ6 8OQ7 8OQ8 8OQA 8RH4 8RH7 8RH8 8RH9 8RHG
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity System Process Modulation Of Chemical Synaptic Transmission Regulation Of Cellular Localization Kinase Activity Regulation Of Steroid Biosynthetic Process Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Regulation Of Steroid Metabolic Process Protein Phosphorylation ATP Binding Plasma Membrane Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Synapse Regulation Of Transport Response To Carbohydrate Positive Regulation Of Cholesterol Metabolic Process Regulation Of Platelet Aggregation Regulation Of Cholesterol Biosynthetic Process Nucleotide Binding Regulation Of Lipid Biosynthetic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Postsynapse Protein Catabolic Process Dendrite Development Regulation Of Intracellular Signal Transduction Regulation Of Muscle System Process Sperm Midpiece Regulation Of Cholesterol Metabolic Process Protein Targeting To Vacuole Cell Communication Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Intracellular Transport Regulation Of Platelet Activation Positive Regulation Of Calcium-mediated Signaling Response To Stress Induction Of Synaptic Plasticity By Chemical Substance	Monoatomic Ion Channel Activity Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Regulation Of Membrane Potential GABA Receptor Activity Regulation Of Postsynaptic Membrane Potential Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Cell-cell Signaling Signaling Cell Communication Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport GABA-gated Chloride Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Monoatomic Ion Transport Postsynaptic Membrane Purinergic Nucleotide Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Transmembrane Transport Response To ATP Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Complex Positive Regulation Of Calcium Ion Transmembrane Transport Excitatory Postsynaptic Potential Chloride Channel Activity Modulation Of Chemical Synaptic Transmission Chloride Transmembrane Transport Positive Regulation Of Calcium Ion Transport GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Suramin Binding Regulation Of Biological Quality GABA Receptor Complex Serotonin Secretion By Platelet Positive Regulation Of Monoatomic Ion Transport Calcium Ion Transmembrane Transport Serotonin Secretion Insemination
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