GABRR1 and P2RX2

Number of citations of the paper that reports this interaction (PMID 14660627)
11

Data Source:
HPRD (in vitro, in vivo)

		GABRR1	P2RX2
Gene Name		gamma-aminobutyric acid (GABA) A receptor, rho 1	purinergic receptor P2X, ligand gated ion channel, 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane	Integral Component Of Nuclear Inner Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Apical Plasma Membrane Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Receptor Complex
	Molecular Function	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity	Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Copper Ion Binding ATP Binding Drug Binding Zinc Ion Binding Ligand-gated Ion Channel Activity Nickel Cation Binding Phosphatidylinositol Binding Identical Protein Binding Mercury Ion Binding Cadmium Ion Binding Cobalt Ion Binding
	Biological Process	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport	Response To Hypoxia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Neuromuscular Synaptic Transmission Neuromuscular Junction Development Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Neuronal Action Potential Peristalsis Response To ATP Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Protein Homooligomerization Protein Heterooligomerization Cation Transmembrane Transport
Pathways		GABA receptor activation GABA A (rho) receptor activation Ion channel transport Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Transmission across Chemical Synapses
Drugs		Lorazepam Temazepam Clobazam Alprazolam Picrotoxin Chlordiazepoxide Adinazolam Clorazepate Midazolam Flurazepam Halazepam Diazepam Oxazepam Triazolam Clonazepam Estazolam Bromazepam Clotiazepam Fludiazepam Prazepam Quazepam Cinolazepam Nitrazepam
Diseases
GWAS		Bipolar disorder and schizophrenia ( 20889312)
Protein-Protein Interactions		10 interactors: CSNK2A1 GABRR2 MAP1B MAPK1 P2RX2 PRKACA PRKCA PRKG1 SLC6A9 SQSTM1	3 interactors: GABRR1 P2RX1 P2RX3
Entrez ID		2569	22953
HPRD ID		15921	15984
Ensembl ID		ENSG00000146276	ENSG00000187848
Uniprot IDs		P24046	Q32MC3 Q9UBL9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Platelet Aggregation Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Platelet Activation Histone H3-T6 Phosphorylation Peptidyl-threonine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Synaptic Transmission Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Protein Phosphorylation Cell Differentiation Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Glucose Import Movement Of Cell Or Subcellular Component Positive Regulation Of Macrophage Differentiation Desmosome Organization Peptidyl-serine Phosphorylation Cell-cell Signaling Blood Coagulation Regulation Of Wound Healing Hemostasis Regulation Of Intracellular Transport Negative Regulation Of Glucose Transport Apoptotic Process Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Programmed Cell Death Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Development Regulation Of Cellular Localization Regulation Of Muscle Contraction Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cell Death Death Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Response To Carbohydrate Cellular Response To Fibroblast Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Response To Fibroblast Growth Factor Platelet Activation	Response To ATP Neuronal Action Potential Purinergic Nucleotide Receptor Signaling Pathway Synaptic Transmission Transmission Of Nerve Impulse Action Potential Cell-cell Signaling Response To Organophosphorus Response To Purine-containing Compound Ion Transmembrane Transport Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Protein Homooligomerization Serotonin Secretion By Platelet Inorganic Anion Transport Regulation Of Membrane Potential Transmembrane Transport Ion Transport Serotonin Secretion Regulation Of Vascular Smooth Muscle Contraction Serotonin Transport Protein Oligomerization Urinary Bladder Smooth Muscle Contraction Peristalsis Regulation Of Ion Transport Insemination Anion Transport Cell Surface Receptor Signaling Pathway Behavioral Response To Pain Copulation Positive Regulation Of Transport Neuromuscular Synaptic Transmission Monoamine Transport Positive Regulation Of Calcium-mediated Signaling Production Of Molecular Mediator Involved In Inflammatory Response Response To Organonitrogen Compound Gamma-aminobutyric Acid Signaling Pathway Response To Organic Cyclic Compound Vasoconstriction Cation Transmembrane Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Response To Pain Synaptic Transmission, Glutamatergic Regulation Of Calcium-mediated Signaling Protein Complex Assembly Ceramide Biosynthetic Process Mating Regulation Of Smooth Muscle Contraction Neurological System Process Response To Cold
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