P2RX2 and P2RX1

Number of citations of the paper that reports this interaction (PMID 15313628)
32

Data Source:
HPRD (in vitro)

		P2RX2	P2RX1
Gene Name		purinergic receptor P2X, ligand gated ion channel, 2	purinergic receptor P2X, ligand gated ion channel, 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Apical Plasma Membrane Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Receptor Complex	Integral Component Of Nuclear Inner Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Cell Outer Membrane Neuron Projection Protein Complex Membrane Raft Postsynaptic Membrane
	Molecular Function	Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Copper Ion Binding ATP Binding Drug Binding Zinc Ion Binding Ligand-gated Ion Channel Activity Nickel Cation Binding Phosphatidylinositol Binding Identical Protein Binding Mercury Ion Binding Cadmium Ion Binding Cobalt Ion Binding	Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Cation Channel Activity Calcium Channel Activity ATP Binding Drug Binding Zinc Ion Binding
	Biological Process	Response To Hypoxia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Neuromuscular Synaptic Transmission Neuromuscular Junction Development Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Neuronal Action Potential Peristalsis Response To ATP Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Protein Homooligomerization Protein Heterooligomerization Cation Transmembrane Transport	Serotonin Secretion By Platelet Regulation Of Vascular Smooth Muscle Contraction Transport Ion Transport Cation Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Insemination Blood Coagulation Regulation Of Blood Pressure Neuronal Action Potential Platelet Activation Response To ATP Synaptic Transmission, Glutamatergic Purinergic Nucleotide Receptor Signaling Pathway Vasoconstriction Positive Regulation Of Ion Transport Ceramide Biosynthetic Process Protein Homooligomerization Protein Heterooligomerization Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport Cation Transmembrane Transport
Pathways			Platelet homeostasis Elevation of cytosolic Ca2+ levels Platelet calcium homeostasis
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GABRR1 P2RX1 P2RX3	1 interactors: P2RX2
Entrez ID		22953	5023
HPRD ID		15984	07526
Ensembl ID		ENSG00000187848	ENSG00000108405
Uniprot IDs		Q32MC3 Q9UBL9	P51575
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To ATP Neuronal Action Potential Purinergic Nucleotide Receptor Signaling Pathway Synaptic Transmission Transmission Of Nerve Impulse Action Potential Cell-cell Signaling Response To Organophosphorus Response To Purine-containing Compound Ion Transmembrane Transport Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Protein Homooligomerization Serotonin Secretion By Platelet Inorganic Anion Transport Regulation Of Membrane Potential Transmembrane Transport Ion Transport Serotonin Secretion Regulation Of Vascular Smooth Muscle Contraction Serotonin Transport Protein Oligomerization Urinary Bladder Smooth Muscle Contraction Peristalsis Regulation Of Ion Transport Insemination Anion Transport Cell Surface Receptor Signaling Pathway Behavioral Response To Pain Copulation Positive Regulation Of Transport Neuromuscular Synaptic Transmission Monoamine Transport Positive Regulation Of Calcium-mediated Signaling Production Of Molecular Mediator Involved In Inflammatory Response Response To Organonitrogen Compound Gamma-aminobutyric Acid Signaling Pathway Response To Organic Cyclic Compound Vasoconstriction Cation Transmembrane Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Response To Pain Synaptic Transmission, Glutamatergic Regulation Of Calcium-mediated Signaling Protein Complex Assembly Ceramide Biosynthetic Process Mating Regulation Of Smooth Muscle Contraction Neurological System Process Response To Cold	Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Urinary Bladder Smooth Muscle Contraction Peristalsis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Behavioral Response To Pain Skeletal Muscle Fiber Development Neuromuscular Synaptic Transmission Response To ATP Positive Regulation Of Calcium-mediated Signaling Myotube Cell Development Neuronal Action Potential Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Response To Pain Regulation Of Calcium-mediated Signaling Muscle Fiber Development Neuromuscular Junction Development Transmission Of Nerve Impulse Myotube Differentiation Smooth Muscle Contraction Sensory Perception Of Taste Regulation Of Calcium Ion Transport Into Cytosol Action Potential Multicellular Organismal Response To Stress Positive Regulation Of Calcium Ion Transport Regulation Of Systemic Arterial Blood Pressure Protein Heterooligomerization Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Response To Organophosphorus Sensory Perception Of Sound Striated Muscle Cell Development Regulation Of Ion Homeostasis Muscle Cell Development Synapse Organization Response To Purine-containing Compound Regulation Of Blood Pressure Sensory Perception Of Mechanical Stimulus Response To Carbohydrate Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Muscle Contraction Striated Muscle Cell Differentiation Positive Regulation Of Intracellular Transport Protein Homooligomerization Muscle System Process Regulation Of Membrane Potential Muscle Organ Development Response To Hypoxia Blood Circulation
Tagcloud ?			bipolar bpd creb1 dd depressed depression depressive dysregulation examining females financial hpa lesser leukocytes mdd medication nfkb1 nr3c1 oxtr p2rx7 p2ry1 purinergic qpcr refractory replicated served sparc trpv1 trpv4
Tagcloud (Difference) ?			bipolar bpd creb1 dd depressed depression depressive dysregulation examining females financial hpa lesser leukocytes mdd medication nfkb1 nr3c1 oxtr p2rx7 p2ry1 purinergic qpcr refractory replicated served sparc trpv1 trpv4
Tagcloud (Intersection) ?