GABRR1 and SLC6A9

Number of citations of the paper that reports this interaction (PubMedID 10625616)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GABRR1	SLC6A9
Description		gamma-aminobutyric acid type A receptor subunit rho1	solute carrier family 6 member 9
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex Presynaptic Membrane Synapse Postsynaptic Membrane Intracellular Vesicle Glutamatergic Synapse GABA-ergic Synapse GABA-A Receptor Complex	Endosome Plasma Membrane Basal Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Synaptic Vesicle Membrane Dense Core Granule Asymmetric Synapse Presynaptic Membrane Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA Receptor Activity Protein Domain Specific Binding GABA-gated Chloride Ion Channel Activity Identical Protein Binding Protein-containing Complex Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential	Amino Acid:sodium Symporter Activity Glycine Transmembrane Transporter Activity Symporter Activity Glycine:sodium Symporter Activity Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Synaptic Transmission, GABAergic Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport	Neurotransmitter Uptake Neurotransmitter Transport Amino Acid Transport Glycine Transport Sodium Ion Transmembrane Transport Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Synaptic Transmission, Glycinergic Glycine Secretion, Neurotransmission Positive Regulation Of Heme Biosynthetic Process Transport Across Blood-brain Barrier Glycine Import Across Plasma Membrane
Pathways		GABA receptor activation	SLC-mediated transport of neurotransmitters
Drugs		Lindane Picrotoxin Fludiazepam TPMPA
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder and schizophrenia ( 20889312) Diabetic kidney disease in type 2 diabetes ( 29703844) Early diabetic kidney disease in type 2 diabetes ( 29703844) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)	Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 29403010 32888494) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: CSNK2A1 GABRR2 MAP1B MAPK1 P2RX2 PRKACA PRKCA PRKG1 SLC6A9 SQSTM1	3 interacting genes: GABRR1 PRKCA STX1A
Entrez ID		2569	6536
HPRD ID		15921	03010
Ensembl ID		ENSG00000146276	ENSG00000196517
Uniprot IDs		P24046	B7Z3A9 B7Z3W8 B7Z589 P48067
PDB IDs		8OP9 8OQ6 8OQ7 8OQ8 8OQA 8RH4 8RH7 8RH8 8RH9 8RHG	6ZBV 6ZPL 8WFI 8WFJ 8WFK 8WFL 9J8B 9J8C 9J8D
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity System Process Modulation Of Chemical Synaptic Transmission Regulation Of Cellular Localization Kinase Activity Regulation Of Steroid Biosynthetic Process Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Regulation Of Steroid Metabolic Process Protein Phosphorylation ATP Binding Plasma Membrane Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Synapse Regulation Of Transport Response To Carbohydrate Positive Regulation Of Cholesterol Metabolic Process Regulation Of Platelet Aggregation Regulation Of Cholesterol Biosynthetic Process Nucleotide Binding Regulation Of Lipid Biosynthetic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Postsynapse Protein Catabolic Process Dendrite Development Regulation Of Intracellular Signal Transduction Regulation Of Muscle System Process Sperm Midpiece Regulation Of Cholesterol Metabolic Process Protein Targeting To Vacuole Cell Communication Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Intracellular Transport Regulation Of Platelet Activation Positive Regulation Of Calcium-mediated Signaling Response To Stress Induction Of Synaptic Plasticity By Chemical Substance	Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Synaptic Vesicle Priming Presynaptic Active Zone Membrane Protein-containing Complex Binding SNARE Binding Positive Regulation Of Exocytosis Myosin Head/neck Binding Glutamatergic Synapse Presynaptic Membrane Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Membrane Organization Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Membrane Fusion Regulation Of Insulin Secretion Protein Kinase C Signaling Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Histone H4K20me Methyltransferase Activity GABA Receptor Activity Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Exocytosis Histone H4K20me2 Reader Activity Desmosome Assembly ATP-dependent Protein Binding Response To Gravity Chloride Channel Inhibitor Activity Ubiquitin-modified Histone Reader Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Trans-synaptic Signaling GABA-A Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Synaptic Signaling GABA-A Receptor Complex Chemical Synaptic Transmission GABA-gated Chloride Ion Channel Activity Regulation Of Hormone Secretion Mitotic Nuclear Membrane Disassembly Diacylglycerol Binding Positive Regulation Of Secretion Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
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