GABRR1 and SLC6A9

Number of citations of the paper that reports this interaction (PMID 10625616)
7

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		GABRR1	SLC6A9
Gene Name		gamma-aminobutyric acid (GABA) A receptor, rho 1	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity	Neurotransmitter:sodium Symporter Activity Glycine:sodium Symporter Activity
	Biological Process	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport	Amino Acid Transmembrane Transport Transport Neurotransmitter Transport Glycine Transport Transmembrane Transport
Pathways		GABA receptor activation GABA A (rho) receptor activation Ion channel transport Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Transmission across Chemical Synapses	Na+/Cl- dependent neurotransmitter transporters Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport
Drugs		Lorazepam Temazepam Clobazam Alprazolam Picrotoxin Chlordiazepoxide Adinazolam Clorazepate Midazolam Flurazepam Halazepam Diazepam Oxazepam Triazolam Clonazepam Estazolam Bromazepam Clotiazepam Fludiazepam Prazepam Quazepam Cinolazepam Nitrazepam	Glycine
Diseases
GWAS		Bipolar disorder and schizophrenia ( 20889312)
Protein-Protein Interactions		10 interactors: CSNK2A1 GABRR2 MAP1B MAPK1 P2RX2 PRKACA PRKCA PRKG1 SLC6A9 SQSTM1	3 interactors: GABRR1 PRKCA STX1A
Entrez ID		2569	6536
HPRD ID		15921	03010
Ensembl ID		ENSG00000146276	ENSG00000196517
Uniprot IDs		P24046	B7Z3W8 P48067
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Platelet Aggregation Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Platelet Activation Histone H3-T6 Phosphorylation Peptidyl-threonine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Synaptic Transmission Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Protein Phosphorylation Cell Differentiation Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Glucose Import Movement Of Cell Or Subcellular Component Positive Regulation Of Macrophage Differentiation Desmosome Organization Peptidyl-serine Phosphorylation Cell-cell Signaling Blood Coagulation Regulation Of Wound Healing Hemostasis Regulation Of Intracellular Transport Negative Regulation Of Glucose Transport Apoptotic Process Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Programmed Cell Death Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Development Regulation Of Cellular Localization Regulation Of Muscle Contraction Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cell Death Death Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Response To Carbohydrate Cellular Response To Fibroblast Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Response To Fibroblast Growth Factor Platelet Activation	Synaptic Transmission Cell-cell Signaling Energy Reserve Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Insulin Secretion Histone H3-T6 Phosphorylation Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Energy Derivation By Oxidation Of Organic Compounds Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Secretion Generation Of Precursor Metabolites And Energy Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Response To Gravity Positive Regulation Of Neurotransmitter Secretion Regulation Of Protein Transport Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Regulation Of Secretion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Anion Transport Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Establishment Of Protein Localization Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Glutamate Secretion Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Protein Localization Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Regulation Of Platelet Activation Membrane Organization Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Regulation Of Synaptic Vesicle Exocytosis
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