GABRR1 and GABRR2

Number of citations of the paper that reports this interaction (PMID 9153229)
1

Data Source:
HPRD (in vitro)

		GABRR1	GABRR2
Gene Name		gamma-aminobutyric acid (GABA) A receptor, rho 1	gamma-aminobutyric acid (GABA) A receptor, rho 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane
	Molecular Function	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Protein Domain Specific Binding
	Biological Process	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport	Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Visual Perception Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		GABA receptor activation GABA A (rho) receptor activation Ion channel transport Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Transmission across Chemical Synapses	GABA receptor activation GABA A (rho) receptor activation Ion channel transport Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Transmission across Chemical Synapses
Drugs		Lorazepam Temazepam Clobazam Alprazolam Picrotoxin Chlordiazepoxide Adinazolam Clorazepate Midazolam Flurazepam Halazepam Diazepam Oxazepam Triazolam Clonazepam Estazolam Bromazepam Clotiazepam Fludiazepam Prazepam Quazepam Cinolazepam Nitrazepam
Diseases
GWAS		Bipolar disorder and schizophrenia ( 20889312)
Protein-Protein Interactions		10 interactors: CSNK2A1 GABRR2 MAP1B MAPK1 P2RX2 PRKACA PRKCA PRKG1 SLC6A9 SQSTM1	5 interactors: CSNK2A1 GABRR1 MAP1B PRKCA SQSTM1
Entrez ID		2569	2570
HPRD ID		15921	15922
Ensembl ID		ENSG00000146276	ENSG00000111886
Uniprot IDs		P24046	P28476
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Platelet Aggregation Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Platelet Activation Histone H3-T6 Phosphorylation Peptidyl-threonine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Synaptic Transmission Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Protein Phosphorylation Cell Differentiation Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Glucose Import Movement Of Cell Or Subcellular Component Positive Regulation Of Macrophage Differentiation Desmosome Organization Peptidyl-serine Phosphorylation Cell-cell Signaling Blood Coagulation Regulation Of Wound Healing Hemostasis Regulation Of Intracellular Transport Negative Regulation Of Glucose Transport Apoptotic Process Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Programmed Cell Death Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Development Regulation Of Cellular Localization Regulation Of Muscle Contraction Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cell Death Death Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Response To Carbohydrate Cellular Response To Fibroblast Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Response To Fibroblast Growth Factor Platelet Activation	Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Cell Growth Histone H3-T6 Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Cell Death Death Positive Regulation Of Growth Neurotrophin Signaling Pathway Positive Regulation Of Protein Metabolic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Phosphorylation Establishment Of Monopolar Cell Polarity Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Cell Differentiation Regulation Of Cell Growth Apoptotic Signaling Pathway Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Regulation Of Cell Death Mitochondrion Transport Along Microtubule Desmosome Organization Negative Regulation Of Transport Regulation Of Mitotic Cell Cycle Establishment Of Mitochondrion Localization Positive Regulation Of Macroautophagy Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To External Stimulus Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Phosphorylation Negative Regulation Of Adenylate Cyclase Activity Axonogenesis Negative Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Rhodopsin Mediated Signaling Pathway Axon Development Cellular Response To Growth Factor Stimulus
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